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Pro-inflammatory and Anti-inflammatory Cytokines in Vitreous Fluid of Patients with Proliferative Diabetic Retinopathy

Year 2009, Volume: 3 Issue: 2, 13 - 16, 01.07.2009

M. A. Abdel Hamid T. El-sergani A. T. Shoheir A. A. Shoumen

Abstract

To determine the intra-vitreous levels of two pro-inflammatory cytokines [interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1)] and the anti-inflammatory cytokine interleukin-10 (IL-10) in patients with proliferative diabetic retinopathy (PDR). In addition, the relationship between the level of cytokines and PDR activity had also been evaluated. The study included 23 diabetic patients with PDR (13 diabetic patients with inactive PDR and 10 diabetic patients with active PDR). Sixteen age-matched non-diabetic patients with macular hole served as a control group. IL-8, MCP-1 and IL-10 were measured by enzyme-linked immunosorbent assay (ELISA). The vitreal levels of both IL-8 and MCP-1 were significantly higher in diabetic patients with PDR in comparison with the control group. In addition, the vitreous concentrations of IL-8 and MCP-1 were higher in patients with active PDR than in those patients with inactive PDR However, no significant difference was detected in the vitreal levels of IL-10 between diabetic patients and the control group. The pro-inflammatory cytokines IL-8 and MCP-1 are increased in the vitreous fluid of PDR patients without an increase in the anti-inflammatory cytokine IL-10. In addition, both intra-vitreous IL-8 and MCP-1 levels are asssociated with PDR activity, thus suggesting that these cytokines may be pathogenically related to PDR

Keywords

IL-8 IL-10 MCP-1 vitreous fluid proliferative diabetic retinopathy

Year 2009, Volume: 3 Issue: 2, 13 - 16, 01.07.2009

M. A. Abdel Hamid T. El-sergani A. T. Shoheir A. A. Shoumen

Abstract

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Details

Other ID JA24VC26TT
Journal Section Research Article
Authors

M. A. Abdel Hamid This is me

T. El-sergani This is me

A. T. Shoheir This is me

A. A. Shoumen This is me

Publication Date July 1, 2009
Published in Issue Year 2009 Volume: 3 Issue: 2

Cite

APA Hamid, M. A. A., El-sergani, T., Shoheir, A. T., Shoumen, A. A. (2009). Pro-inflammatory and Anti-inflammatory Cytokines in Vitreous Fluid of Patients with Proliferative Diabetic Retinopathy. Journal of Applied Biological Sciences, 3(2), 13-16.
AMA Hamid MAA, El-sergani T, Shoheir AT, Shoumen AA. Pro-inflammatory and Anti-inflammatory Cytokines in Vitreous Fluid of Patients with Proliferative Diabetic Retinopathy. J.appl.biol.sci. July 2009;3(2):13-16.
Chicago Hamid, M. A. Abdel, T. El-sergani, A. T. Shoheir, and A. A. Shoumen. “Pro-Inflammatory and Anti-Inflammatory Cytokines in Vitreous Fluid of Patients With Proliferative Diabetic Retinopathy”. Journal of Applied Biological Sciences 3, no. 2 (July 2009): 13-16.
EndNote Hamid MAA, El-sergani T, Shoheir AT, Shoumen AA (July 1, 2009) Pro-inflammatory and Anti-inflammatory Cytokines in Vitreous Fluid of Patients with Proliferative Diabetic Retinopathy. Journal of Applied Biological Sciences 3 2 13–16.
IEEE M. A. A. Hamid, T. El-sergani, A. T. Shoheir, and A. A. Shoumen, “Pro-inflammatory and Anti-inflammatory Cytokines in Vitreous Fluid of Patients with Proliferative Diabetic Retinopathy”, J.appl.biol.sci., vol. 3, no. 2, pp. 13–16, 2009.
ISNAD Hamid, M. A. Abdel et al. “Pro-Inflammatory and Anti-Inflammatory Cytokines in Vitreous Fluid of Patients With Proliferative Diabetic Retinopathy”. Journal of Applied Biological Sciences 3/2 (July 2009), 13-16.
JAMA Hamid MAA, El-sergani T, Shoheir AT, Shoumen AA. Pro-inflammatory and Anti-inflammatory Cytokines in Vitreous Fluid of Patients with Proliferative Diabetic Retinopathy. J.appl.biol.sci. 2009;3:13–16.
MLA Hamid, M. A. Abdel et al. “Pro-Inflammatory and Anti-Inflammatory Cytokines in Vitreous Fluid of Patients With Proliferative Diabetic Retinopathy”. Journal of Applied Biological Sciences, vol. 3, no. 2, 2009, pp. 13-16.
Vancouver Hamid MAA, El-sergani T, Shoheir AT, Shoumen AA. Pro-inflammatory and Anti-inflammatory Cytokines in Vitreous Fluid of Patients with Proliferative Diabetic Retinopathy. J.appl.biol.sci. 2009;3(2):13-6.