Screening for Deletions in the AZF Region of Y Chromosome in Infertile Jordanian Males

Osamah Batiha; Mohammed A. Al-ghazo; Ahmed M. Elbetieha; Saied A. Jaradat

Screening for Deletions in the AZF Region of Y Chromosome in Infertile Jordanian Males

Year 2012, Volume: 6 Issue: 2, 19 - 22, 01.07.2012

Osamah Batiha Mohammed A. Al-ghazo Ahmed M. Elbetieha Saied A. Jaradat

Abstract

Infertility is a serious problem that affects between 10%-15% of couples all over the world in which half of these cases are attributed to males. Deletions in the azoospermia factor (AZF) of the Y chromosome have been investigated and shown to be associated with azoospermia and severe oligozoospermia in many populations. However, the percentages of microdeletions were somehow variable. The purpose of this study was to investigate the association between microdeletions in the AZF region of the Y chromosome and infertility among male Jordanians.A total of 65 oligoozospermic and non-obstructive azoospermic infertile men (Study group) and 20 fertile men (control group) were investigated for microdeletions in the AZF using multiplex PCR. We found one out of 65 (1.5%) had Y microdeletions. Microdeletions were detected in the AZFb and AZFc regions. The percentage of Y chromosome microdeletions in Jordanian infertile males is considered low compared to that from other countries. We also report a molecular genetic characterization of a sex-reversed 46,XX male, a very rare genetic abnormality in humans

Keywords

Y chromosome microdeletions, male infertility

Year 2012, Volume: 6 Issue: 2, 19 - 22, 01.07.2012

Osamah Batiha Mohammed A. Al-ghazo Ahmed M. Elbetieha Saied A. Jaradat

Abstract

There are 0 citations in total.

Details

Other ID	JA48AJ52ZH
Journal Section	Research Article
Authors	Osamah Batiha This is me Mohammed A. Al-ghazo This is me Ahmed M. Elbetieha This is me Saied A. Jaradat This is me
Publication Date	July 1, 2012
Published in Issue	Year 2012 Volume: 6 Issue: 2

Cite

APA	Batiha, O., Al-ghazo, M. A., Elbetieha, A. M., Jaradat, S. A. (2012). Screening for Deletions in the AZF Region of Y Chromosome in Infertile Jordanian Males. Journal of Applied Biological Sciences, 6(2), 19-22.
AMA	Batiha O, Al-ghazo MA, Elbetieha AM, Jaradat SA. Screening for Deletions in the AZF Region of Y Chromosome in Infertile Jordanian Males. J.appl.biol.sci. July 2012;6(2):19-22.
Chicago	Batiha, Osamah, Mohammed A. Al-ghazo, Ahmed M. Elbetieha, and Saied A. Jaradat. “Screening for Deletions in the AZF Region of Y Chromosome in Infertile Jordanian Males”. Journal of Applied Biological Sciences 6, no. 2 (July 2012): 19-22.
EndNote	Batiha O, Al-ghazo MA, Elbetieha AM, Jaradat SA (July 1, 2012) Screening for Deletions in the AZF Region of Y Chromosome in Infertile Jordanian Males. Journal of Applied Biological Sciences 6 2 19–22.
IEEE	O. Batiha, M. A. Al-ghazo, A. M. Elbetieha, and S. A. Jaradat, “Screening for Deletions in the AZF Region of Y Chromosome in Infertile Jordanian Males”, J.appl.biol.sci., vol. 6, no. 2, pp. 19–22, 2012.
ISNAD	Batiha, Osamah et al. “Screening for Deletions in the AZF Region of Y Chromosome in Infertile Jordanian Males”. Journal of Applied Biological Sciences 6/2 (July 2012), 19-22.
JAMA	Batiha O, Al-ghazo MA, Elbetieha AM, Jaradat SA. Screening for Deletions in the AZF Region of Y Chromosome in Infertile Jordanian Males. J.appl.biol.sci. 2012;6:19–22.
MLA	Batiha, Osamah et al. “Screening for Deletions in the AZF Region of Y Chromosome in Infertile Jordanian Males”. Journal of Applied Biological Sciences, vol. 6, no. 2, 2012, pp. 19-22.
Vancouver	Batiha O, Al-ghazo MA, Elbetieha AM, Jaradat SA. Screening for Deletions in the AZF Region of Y Chromosome in Infertile Jordanian Males. J.appl.biol.sci. 2012;6(2):19-22.