A Study of Cancer-Related Genes: Prevalence of Polymorphic GSTT1 and GSTM1 Deletions in Turkey

Year 2013, Volume: 7 Issue: 2, 1 - 3, 01.07.2013

Sefayet Karaca Mehmet Karaca Ayşe Kaymaz

Abstract

The major burden of cancer in the general population is results from the complex interactions of multiple genetic and environmental factors over time. Population based studies support the involvement of GSTM1 and GSTT1 deletion in susceptibility to commonly occurring forms of cancer. The aim of this study was to determine frequency of GSTM1 and GSTT1 deletion variants in Turkish population. Deletion polymorphisms were screened in a collection of samples n=507 for GSTM1 and n=464 for GSTT1. After isolation of DNAs from whole blood, sequences of interest were amplified and then analyzed by electrophoretic methods in the presence of positive and negative controls. Allele frequencies were detected as 52% for GSTM1 and 24% for GSTT1 deletion polymorphisms. The obtained frequencies were consistent with the values that reported for different populations. Cancer is a disease of the genome and identification of the genetic characteristics of healthy individuals is important in determining of current risks, developing of preventive health care models and medical follow-up programs to reducing risk of diseases. However, during the treatment process it allows the selection of optimal therapy

Keywords

cancer genetics, GSTM1 and GSTT1 deletions