Paradoxical Advantage of Middle Aged Sedentary over Young Sedentary on Starting Exercise in Terms of GH/IGF-1 System

Year 2018, Volume: 12 Issue: 3, 21 - 25, 26.12.2018

Nizamettin Gunbatar , Mehmet Salih Kaya , Tahir Kahraman Fahri Bayiroglu

Abstract

The aim of this study was to investigate
the effects of the submaximal running exercise on the GH/IGF-1 axis in the middle
aged sedentary nonobese and preobese males. 24 healthy volunteer males were divided
into 2 groups and then 2 subgroups according to their age ranges (20-25 and
35-43) and Body Mass Indexes (BMI) (nonobese- NO and preobese- PO) respectively.
All subjects underwent a submaximal running exercise for 30 minutes a day/ 4
days a week and for a period of 6 weeks. Serum GH, IGF-1, IGFBP-3, and insulin
levels were measured in all subjects before and after the exercise program. IGFBP-3
levels were found to be statistically decreased in the PO middle aged and NO
young groups whereas IGF-1 levels were statistically increased in NO young
group after the exercise treatment. Surprisingly PO and NO middle aged groups’
Insulin and GH responses against exercise were quite opposite of those observed
in young groups. In the light of the findings, it could be suggested that the
middle aged group’s response against exercise on the base of GH/IGF-1 system
was more effective than the young group, was found to be quite interesting.

Keywords

Exercise, preobese, middle aged, sedentary, GH/IGF-1 system

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