Parvovirus ile Enfekte Köpeklerde Nötrofil/Lenfosit, Monosit/Lenfosit ve Platelet/Lenfosit Oranlarının Belirlenmesi

Didem Pekmezci; Zeynep Nurselin Çolak

doi:10.35229/jaes.993377

EN TR

Determination of Neutrophil/Lymphocyte, Monocyte/Lymphocyte and Platelet/Lymphocyte Ratios in Dogs with Occurring Parvovirus Infection

Abstract

Neutrophil/lymphocyte ratio (NEU/LYM), monocyte/lymphocyte ratio (MONO/LYM), and platelet/lymphocyte ratio (PLT/LYM) are inexpensive and reproducible biomarkers of inflammation. This is the first study that explores NEU/LYM, MONO/LYM, and PLT/LYM in dogs with Parvovirus infection (PVI). This study aims to determine whether the pretreatment NEU/LYM, MONO/LYM, and PLT/LYM differs in dogs with PVI against healthy controls. Eighteen client-owned dogs aged 2-8 months that were found positive with PVI were enrolled as the study group. Seven client-owned, healthy dogs of the same age formed the control group. Pretreatment NEU/LYM, MONO/LYM, and PLT/LYM were compared between groups. The pretreatment mean NEU (P< 0.001) and LYM (P<0.05) levels were found to be significantly lower in the study group when compared to the control group. However, pretreatment mean PLT/LYM levels in the PVI positive group was significantly higher (P<0.001) than in the control group. The mean PLT/LYM levels in the PVI positive and control groups were found as 1120.94 and 135.26, respectively. In summary, this preliminary study demonstrates that pretreatment PLT/LYM in dogs with PVI positive is an easy, cost-effective, objective, and non-invasive biomarker that could be the new prognostic marker candidates in dogs naturally infected with PVI. Although limited studies on NEU/LYM, MONO/LYM, PLT/LYM are existed, especially further studies in veterinary medicine with infectious diseases are needed.

Keywords

Neutrophil/lymphocyte ratio, Monocyte/lymphocyte ratio, Platelet/lymphocyte ratio, Parvovirus, Dog

Parvovirus ile Enfekte Köpeklerde Nötrofil/Lenfosit, Monosit/Lenfosit ve Platelet/Lenfosit Oranlarının Belirlenmesi

Abstract

Nötrofil/lenfosit oranı (NEU/LYM), monosit/lenfosit oranı (MONO/LYM), ve platelet/lenfosit oranı (PLT/LYM) inflamasyonunun ucuz, tekrar kullanılabilen biyobelirteçlerini oluşturmaktadır. Bu çalışma ilk defa parvovirus enfeksiyonu (PVE) şekillenmiş köpeklerde NEU/LYM, MONO/LYM ve PLT/LYM değerlerini ortaya koymaktadır. Çalışmanın amacını ise tedavi öncesi PVE ile pozitif köpeklerin NEU/LYM, MONO/LYM ve PLT/LYM değerlerinin, sağlıklı kontrollere göre karşılaştırılması oluşturmuştur. On sekiz sahipli, 2-8 aylık, PVE pozitif köpek, çalışma grubunu oluşturmuştur. Yedi sahipli, aynı yaş aralığında sağlıklı köpek ise kontrol grubunu oluşturmuştur. Gruplar arasında tedavi öncesi NEU/LYM, MONO/LYM karşılaştırılmasında PVE pozitif grubu ortalama NEU (P<0,001), LYM (P<0,05) değerleri kontrol grubuna istatistiksel olarak düşük bulunmuştur. Bununla birlikte, PVE pozitif grubunda tedavi öncesi ortalama PLT/LYM seviyeleri kontrol grubuna göre istatistiksel olarak yüksek (P<0,001) tespit edilmiştir. PVE pozitif ve kontrol gruplarında ortalama PLT/LYM düzeyleri ise sırasıyla 1120,94 ve 135,26 olarak bulunmuştur. Sonuç olarak, bu ön çalışma PLT/LYM oranın, PVE ile doğal olarak enfekte olmuş köpeklerde kolay, uygun maliyetli, objektif ve invazif olmayan yeni bir prognostik belirteç adayı olabileceğini göstermektedir. NEU/LYM, MONO/LYM, PLT/LYM ile ilgili çalışmaların kısıtlı varlığına rağmen, özellikle veteriner hekimlikte bulaşıcı hastalıklarda daha ileri çalışmalara ihtiyaç duyulmaktadır.

Keywords

Nötrofil/lenfosit oranı, Monosit/lenfosit oranı, Platelet/lenfosit oranı, Parvovirus, Köpek

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Details

Primary Language

Turkish

Subjects

-

Journal Section

Research Article

Authors

Didem Pekmezci ^*
0000-0003-2072-8165
Türkiye

Zeynep Nurselin Çolak
0000-0002-0631-5471
Türkiye

Publication Date

December 31, 2021

Submission Date

September 9, 2021

Acceptance Date

October 25, 2021

Published in Issue

Year 2021 Volume: 6 Number: 4

DOI

https://doi.org/10.35229/jaes.993377

IZ

https://izlik.org/JA99LT48DX

APA

Pekmezci, D., & Çolak, Z. N. (2021). Parvovirus ile Enfekte Köpeklerde Nötrofil/Lenfosit, Monosit/Lenfosit ve Platelet/Lenfosit Oranlarının Belirlenmesi. Journal of Anatolian Environmental and Animal Sciences, 6(4), 585-591. https://doi.org/10.35229/jaes.993377

AMA

1.Pekmezci D, Çolak ZN. Parvovirus ile Enfekte Köpeklerde Nötrofil/Lenfosit, Monosit/Lenfosit ve Platelet/Lenfosit Oranlarının Belirlenmesi. JAES. 2021;6(4):585-591. doi:10.35229/jaes.993377

Chicago

Pekmezci, Didem, and Zeynep Nurselin Çolak. 2021. “Parvovirus Ile Enfekte Köpeklerde Nötrofil Lenfosit, Monosit Lenfosit Ve Platelet Lenfosit Oranlarının Belirlenmesi”. Journal of Anatolian Environmental and Animal Sciences 6 (4): 585-91. https://doi.org/10.35229/jaes.993377.

EndNote

Pekmezci D, Çolak ZN (December 1, 2021) Parvovirus ile Enfekte Köpeklerde Nötrofil/Lenfosit, Monosit/Lenfosit ve Platelet/Lenfosit Oranlarının Belirlenmesi. Journal of Anatolian Environmental and Animal Sciences 6 4 585–591.

IEEE

[1]D. Pekmezci and Z. N. Çolak, “Parvovirus ile Enfekte Köpeklerde Nötrofil/Lenfosit, Monosit/Lenfosit ve Platelet/Lenfosit Oranlarının Belirlenmesi”, JAES, vol. 6, no. 4, pp. 585–591, Dec. 2021, doi: 10.35229/jaes.993377.

ISNAD

Pekmezci, Didem - Çolak, Zeynep Nurselin. “Parvovirus Ile Enfekte Köpeklerde Nötrofil Lenfosit, Monosit Lenfosit Ve Platelet Lenfosit Oranlarının Belirlenmesi”. Journal of Anatolian Environmental and Animal Sciences 6/4 (December 1, 2021): 585-591. https://doi.org/10.35229/jaes.993377.

JAMA

1.Pekmezci D, Çolak ZN. Parvovirus ile Enfekte Köpeklerde Nötrofil/Lenfosit, Monosit/Lenfosit ve Platelet/Lenfosit Oranlarının Belirlenmesi. JAES. 2021;6:585–591.

MLA

Pekmezci, Didem, and Zeynep Nurselin Çolak. “Parvovirus Ile Enfekte Köpeklerde Nötrofil Lenfosit, Monosit Lenfosit Ve Platelet Lenfosit Oranlarının Belirlenmesi”. Journal of Anatolian Environmental and Animal Sciences, vol. 6, no. 4, Dec. 2021, pp. 585-91, doi:10.35229/jaes.993377.

Vancouver

1.Didem Pekmezci, Zeynep Nurselin Çolak. Parvovirus ile Enfekte Köpeklerde Nötrofil/Lenfosit, Monosit/Lenfosit ve Platelet/Lenfosit Oranlarının Belirlenmesi. JAES. 2021 Dec. 1;6(4):585-91. doi:10.35229/jaes.993377

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JAES/AAS-Journal of Anatolian Environmental and Animal Sciences/Anatolian Academic Sciences&Anadolu Çevre ve Hayvancılık Dergisi/Anadolu Akademik Bilimler-AÇEH/AAS