Case Report
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Bir Hemodiyaliz Hastasında Metastatik Staphylococcus Aureus Enfeksiyonu

Year 2025, Volume: 10 Issue: 3, 96 - 98, 31.12.2025
https://doi.org/10.55694/jamer.1610319

Abstract

Metisiline dirençli Staphylococcus aureus (MRSA), antibiyotik direnci nedeniyle tedavisi zor ve yüksek ölüm oranlarına sahip invaziv enfeksiyonlara neden olmaktadır. Sık hastaneye yatış, antibiyotik kullanımı, invaziv kateterler ve hemodiyaliz MRSA enfeksiyonları için risk faktörleridir. Burada, MRSA'nın etken olduğu pnömoni ve bakteriyemisi olan bir hemodiyaliz hastası bildirilmektedir. Hastada kateter giriş yerinde hassasiyet, laboratuvar değerlerinde akut faz reaktanlarında yükseklik ve akciğerde konsolidasyonlar saptanmıştır. Enfekte kateterin çekilmesi ve uygun antibiyotik tedavisi ile hastanın klinik ve laboratuvar bulgularında tam düzelme sağlanmıştır. Bu vaka, hemodiyaliz hastalarında kateter kaynaklı bakteriyemilerin metastatik enfeksiyonlara yol açabileceğini ve dikkatli bir tarama gerektirdiğini hatırlatmaktadır.

References

  • 1. Rasigade JP, Vandenesch F. Staphylococcus aureus: a pathogen with still unresolved issues. Infect Genet Evol. 2014 Jan;21:510-514.
  • 2. Liu A, Garrett S, Hong W, Zhang J. Staphylococcus aureus Infections and human intestinal microbiota. Pathogens. 2024;13(4):276.
  • 3. Tong SY, Davis JS, Eichenberger E, Holland TL, Fowler VG Jr. Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management. Clin Microbiol Rev. 2015;28(3):603-661.
  • 4. Turner NA, Sharma-Kuinkel BK, Maskarinec SA, Eichenberger EM, Shah PP, Carugati M, et al. Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research. Nat Rev Microbiol. 2019 Apr;17(4):203-218.
  • 5. Siddiqui AH, Koirala J. Methicillin-resistant staphylococcus aureus. [Updated 2023 Apr 2]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan . Available from: https://www. ncbi.nlm.nih.gov/books/NBK482221/
  • 6. Li Z, Zhuang H, Wang G, Wang H, Dong Y. Prevalence, predictors, and mortality of bloodstream infections due to methicillin-resistant staphylococcus aureus in patients with malignancy: systemic review and meta-analysis. BMC Infect Dis. 2021 Jan 14;21(1):74.
  • 7. Nyasinga J, Munshi Z, Kigen C, Nyerere A, Musila L, Whitelaw A, et al. Displacement of hospital-acquired, methicillin-resistant staphylococcus aureus clones by heterogeneous community strains in Kenya over a 13-Year Period. Microorganisms. 2024;12(6):1171.
  • 8. European Centre for Disease Prevention and Control/European Medicines Agency (ECDC/EMEA). Joint technical report The bacterial challenge: time to react. Stockholm:ECDC/EMEA; 2009.
  • 9. Murdeshwar HN, Anjum F. Hemodialysis. [Updated 2023 Apr 27]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/ NBK563296/
  • 10. Kwiecinski JM, Jacobsson G, Horswill AR, Josefsson E, Jin T. Biofilm formation by staphylococcus aureus clinical isolates correlates with the infection type. Infect Dis (Lond). 2019 Jun;51(6):446-451.
  • 11. Kaushik A, Kest H, Sood M, Steussy BW, Thieman C, Gupta S. Biofilm producing methicillin-resistant staphylococcus aureus (MRSA) infections in humans: Clinical Implications and Management. Pathogens. 2024;13(1):76.
  • 12. Karkar A. Infection control guidelines in hemodialysis facilities. Kidney Res Clin Pract. 2018;37(1):1-3.

Metastatic Staphylococcus Aureus Infection in a Haemodialysis Patient

Year 2025, Volume: 10 Issue: 3, 96 - 98, 31.12.2025
https://doi.org/10.55694/jamer.1610319

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) causes invasive infections that are difficult to treat and associated with high mortality rates due to antibiotic resistance. Frequent hospital admissions, antibiotic use, invasive catheters, and hemodialysis are significant risk factors for MRSA infections. Here, we report a case of a hemodialysis patient with pneumonia and bacteremia caused by MRSA. The patient presented with tenderness at the catheter insertion site, elevated acute-phase reactants in laboratory tests, and lung consolidations. Removal of the infected catheter and administration of appropriate antibiotic therapy resulted in complete resolution of the patient's clinical symptoms and laboratory abnormalities. This case highlights the importance of recognizing that catheter-related bacteremia in hemodialysis patients can lead to metastatic infections and necessitates careful screening.

References

  • 1. Rasigade JP, Vandenesch F. Staphylococcus aureus: a pathogen with still unresolved issues. Infect Genet Evol. 2014 Jan;21:510-514.
  • 2. Liu A, Garrett S, Hong W, Zhang J. Staphylococcus aureus Infections and human intestinal microbiota. Pathogens. 2024;13(4):276.
  • 3. Tong SY, Davis JS, Eichenberger E, Holland TL, Fowler VG Jr. Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management. Clin Microbiol Rev. 2015;28(3):603-661.
  • 4. Turner NA, Sharma-Kuinkel BK, Maskarinec SA, Eichenberger EM, Shah PP, Carugati M, et al. Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research. Nat Rev Microbiol. 2019 Apr;17(4):203-218.
  • 5. Siddiqui AH, Koirala J. Methicillin-resistant staphylococcus aureus. [Updated 2023 Apr 2]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan . Available from: https://www. ncbi.nlm.nih.gov/books/NBK482221/
  • 6. Li Z, Zhuang H, Wang G, Wang H, Dong Y. Prevalence, predictors, and mortality of bloodstream infections due to methicillin-resistant staphylococcus aureus in patients with malignancy: systemic review and meta-analysis. BMC Infect Dis. 2021 Jan 14;21(1):74.
  • 7. Nyasinga J, Munshi Z, Kigen C, Nyerere A, Musila L, Whitelaw A, et al. Displacement of hospital-acquired, methicillin-resistant staphylococcus aureus clones by heterogeneous community strains in Kenya over a 13-Year Period. Microorganisms. 2024;12(6):1171.
  • 8. European Centre for Disease Prevention and Control/European Medicines Agency (ECDC/EMEA). Joint technical report The bacterial challenge: time to react. Stockholm:ECDC/EMEA; 2009.
  • 9. Murdeshwar HN, Anjum F. Hemodialysis. [Updated 2023 Apr 27]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/ NBK563296/
  • 10. Kwiecinski JM, Jacobsson G, Horswill AR, Josefsson E, Jin T. Biofilm formation by staphylococcus aureus clinical isolates correlates with the infection type. Infect Dis (Lond). 2019 Jun;51(6):446-451.
  • 11. Kaushik A, Kest H, Sood M, Steussy BW, Thieman C, Gupta S. Biofilm producing methicillin-resistant staphylococcus aureus (MRSA) infections in humans: Clinical Implications and Management. Pathogens. 2024;13(1):76.
  • 12. Karkar A. Infection control guidelines in hemodialysis facilities. Kidney Res Clin Pract. 2018;37(1):1-3.
There are 12 citations in total.

Details

Primary Language English
Subjects ​Internal Diseases
Journal Section Case Report
Authors

Davut Eren 0000-0003-2754-7594

Onur Tatar 0000-0002-9292-5494

Sümeyra Koyuncu 0000-0002-1159-5818

Submission Date December 30, 2024
Acceptance Date October 7, 2025
Publication Date December 31, 2025
Published in Issue Year 2025 Volume: 10 Issue: 3

Cite

Vancouver 1.Eren D, Tatar O, Koyuncu S. Metastatic Staphylococcus Aureus Infection in a Haemodialysis Patient. JAMER [Internet]. 2025 Dec. 1;10(3):96-8. Available from: https://izlik.org/JA53HU52ZZ