Hemodiyaliz Hastalarında Uyku Bozuklukları ve Huzursuz Bacak Sendromu Birlikteliğinin Değerlendirilmesi
Year 2025,
Volume: 10 Issue: 3, 79 - 85, 31.12.2025
Celil Barlas Cengiz
,
Burcu Eren Cengiz
,
Koray Uludag
Abstract
Amaç: Hemodiyalize giren kronik böbrek yetmezliği hastalarında uyku bozukluklarının yaşam kalitesini düşürdüğü bildirilmektedir. Bu çalışmada hemodiyaliz hastalarının uyku kalitesini etkileyebilecek demografik ve biyokimyasal faktörlerin belirlenmesi ve huzursuz bacak sendromu (HBS) sıklığının araştırılması amaçlanmıştır.
Gereç ve Yöntemler: Kayseri Eğitim ve Araştırma Hastanesi hemodiyaliz ünitesinde takip edilen 90 hasta çalışmaya alındı. Hastaların uyku kalitesi Pittsburgh Uyku Kalite İndeksi (PUKİ) ile değerlendirildi. HBS tanısı Uluslararası Huzursuz Bacak Sendromu Çalışma Grubu (IRLSSG) kriterleri kullanılarak konuldu. Hastaların demografik ve biyokimyasal özellikleri incelendi.
Bulgular: Hastaların %55,6’sında kötü uyku kalitesi saptandı. HBS sıklığı %54,4 olarak bulundu ve HBS olan hastaların %69,4’ünde kötü uyku kalitesi mevcuttu. Uyku kalitesi ile HBS arasında istatistiksel olarak anlamlı bir ilişki bulundu (p=0,007). HBS varlığının uyku kalitesini etkileyen bağımsız bir faktör olduğu görüldü (p=0,001).
Sonuç: PUKİ, hemodiyaliz hastalarında uyku bozukluklarını değerlendirmede etkili ve düşük maliyetli bir yöntemdir. Uyku sorunları ve huzursuz bacak sendromu hemodiyaliz tedavisi alan hastaların önemli ölçüde etkilemektedir.
References
-
1. Sun H, Qin K, Zou C, Liu Z, Tang Y, Huang X, et al. The
association of nighttime sleep duration and quality with chronic
kidney disease in middle-aged and older chinese: a cohort study.
Sleep Med. 2021;86:25-231.
-
2. Liu Y, Du Q, Jiang Y. Prevalence of restless legs syndrome in
maintenance haemodialysis patients: A systematic review and
meta-analysis. Sleep Med. 2024;114:15-23.
-
3. Iliescu EA, Coo H, McMurray MH, Meers CL, Quinn MM, Singer
MA, et al. Quality of sleep and health-related quality of life in
haemodialysis patients. Nephrol Dial Transplant. 2003;18(1):126-
132.
-
4. Allen RP, Picchietti DL, Garcia-Borreguero D, Ondo WG, Walters
AS, Winkelman JW, et al. Restless legs syndrome/willis–ekbom
disease diagnostic criteria: updated international restless legs
syndrome study group (IRLSSG) consensus criteria. Sleep Med.
2014;15(8):860-873.
-
5. Mallon L, Broman JE, Hetta J. Restless legs symptoms with
sleepiness in relation to mortality: 20-year follow-up study of
a middle-aged Swedish population. Psychiatry Clin Neurosci.
2008;62(4):457-463.
-
6. Allen RP, Auerbach S, Bahrain H, Auerbach M, Earley CJ. The
prevalence and impact of restless legs syndrome on patients with
iron deficiency anemia. Am J Hematol. 2013;88(4):261-264.
-
7. Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer
DJ. The pittsburgh sleep quality index: a new instrument for
psychiatric practice and research. Psychiatry Res. 1989;28(2):193-
213.
-
8. Eslami AA, Rabiei L, Khayri F, Rashidi Nooshabadi MR, Hosseini
F. Sleep quality and spiritual well-being in hemodialysis patients.
Iran Red Crescent Med J. 2014;16(7):e17155.
-
9. Scherer JS, Combs SA, Brennan F. Sleep disorders, restless
legs syndrome, and uremic pruritus: diagnosis and treatment
of common symptoms in dialysis patients. Am J Kidney Dis.
2017;69(1):117-128.
-
10. Pojatić Đ, Pezerović D, Mihaljević D, Degmečić D. Factors
associated with sleep disorders in patients on chronic hemodialysis
treatment. Seemedj. 2020;4(1):74–86
-
11. Turk AC, Ozkurt S, Turgal E, Basat S, Bozdemir MN, Okyay
GU, et al. The association between the prevalence of restless
leg syndrome, fatigue, and sleep quality in patients undergoing
hemodialysis. Saudi Med J. 2018;39(8):792-798.
-
12. Unruh ML, Buysse DJ, Dew MA, Evans IV, Wu AW, Fink NE, et
al. Sleep quality and its correlates in the first year of dialysis: the
choice study. Clin J Am Soc Nephrol. 2006;1(4):802-810.
-
13. Lichstein KL, Durrence HH, Riedel BW, Taylor DJ, Bush AJ.
Epidemiology of sleep: age, gender, and ethnicity. 1st ed. Mahwah
(NJ): Psychology Press; 2004.
-
14. Caballero-Castañeda L, Flores-Méndez YL, Juárez-Sánchez JO,
García-García P, Hernández-Carmona H, Rodríguez-Flores EA.
Calidad del sueño en pacientes con enfermedad renal crónica en
hemodiálisis [Sleep quality in patients with chronic kidney disease
on hemodialysis]. Rev Med Inst Mex Seguro Soc. 2023;61(2):213-
219.
-
15. Williams SW, Tell GS, Zheng B, Shumaker S, Rocco MV, Sevick
MA. Correlates of sleep behavior among hemodialysis patients:
the KOPE study. Am J Nephrol. 2002;22(1):18-28.
-
16. Lyons OD. Sleep disorders in chronic kidney disease. Nat Rev
Nephrol. 2024;20(10):690-700.
-
17. Ohayon MM. Epidemiological study on insomnia in the general
population. Sleep. 1996;19(Suppl 3):S7-15.
-
18. Kutner NG, Bliwise DL. Restless legs complaint in AfricanAmerican and caucasian hemodialysis patients. Sleep Med.
2002;3(6):497-500.
-
19. Winkelmann J, Schadrack J, Wetter TC, Zieglgänsberger W,
Trenkwalder C. Opioid and dopamine antagonist drug challenges
in untreated restless legs syndrome patients. Sleep Med.
2001;2(1):57-61.
-
20. Earley CJ, Connor JR, Beard JL, Malecki EA, Epstein DK, Allen
RP. Abnormalities inCSF concentrations of ferritin and transferrin
in restless legs syndrome. Neurology. 2000;54(8):1698-1700.
Assessment of Sleep Disorders and Co-Occurrence of Restless Legs Syndrome in Hemodialysis Patients
Year 2025,
Volume: 10 Issue: 3, 79 - 85, 31.12.2025
Celil Barlas Cengiz
,
Burcu Eren Cengiz
,
Koray Uludag
Abstract
Aim: Reports indicate that sleep disturbances diminish the quality of life in people with chronic renal failure receiving haemodialysis. This study aims to identify the demographic and biochemical parameters influencing the sleep quality of haemodialysis patients and to examine the prevalence of restless legs syndrome (RLS).
Materials and Methods: Ninety patients from the haemodialysis unit of Kayseri Training and Research Hospital participated in the study. The Pittsburgh Sleep Quality Index (PSQI) was utilised to assess sleep quality. The diagnosis of Restless Legs Syndrome (RLS) was established according to the criteria set forth by the International Restless Legs Syndrome Study Group (IRLSSG). The patients’ demographic and biochemical parameters were analysed.
Results: Suboptimal sleep quality was identified in 55.6% of the patients. The prevalence of HBS was determined to be 54.4%, with 69.4% of patients with HBS experiencing poor sleep quality. A statistically significant correlation was identified between sleep quality and HBS (p=0.007). The presence of RLS was independently associated with poor sleep quality (p=0.001)
Conclusion: PSQI serves as an efficient and economical approach for assessing sleep problems in individuals undergoing haemodialysis. Sleep disturbances and restless leg syndrome dramatically impact individuals receiving haemodialysis therapy.
Ethical Statement
Çalışma Erciyes Üniversitesi Etik kurulu tarafından 12 Ocak 2018 de 2018/13 KARAR NO İLE ONAYLANIŞTIR
References
-
1. Sun H, Qin K, Zou C, Liu Z, Tang Y, Huang X, et al. The
association of nighttime sleep duration and quality with chronic
kidney disease in middle-aged and older chinese: a cohort study.
Sleep Med. 2021;86:25-231.
-
2. Liu Y, Du Q, Jiang Y. Prevalence of restless legs syndrome in
maintenance haemodialysis patients: A systematic review and
meta-analysis. Sleep Med. 2024;114:15-23.
-
3. Iliescu EA, Coo H, McMurray MH, Meers CL, Quinn MM, Singer
MA, et al. Quality of sleep and health-related quality of life in
haemodialysis patients. Nephrol Dial Transplant. 2003;18(1):126-
132.
-
4. Allen RP, Picchietti DL, Garcia-Borreguero D, Ondo WG, Walters
AS, Winkelman JW, et al. Restless legs syndrome/willis–ekbom
disease diagnostic criteria: updated international restless legs
syndrome study group (IRLSSG) consensus criteria. Sleep Med.
2014;15(8):860-873.
-
5. Mallon L, Broman JE, Hetta J. Restless legs symptoms with
sleepiness in relation to mortality: 20-year follow-up study of
a middle-aged Swedish population. Psychiatry Clin Neurosci.
2008;62(4):457-463.
-
6. Allen RP, Auerbach S, Bahrain H, Auerbach M, Earley CJ. The
prevalence and impact of restless legs syndrome on patients with
iron deficiency anemia. Am J Hematol. 2013;88(4):261-264.
-
7. Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer
DJ. The pittsburgh sleep quality index: a new instrument for
psychiatric practice and research. Psychiatry Res. 1989;28(2):193-
213.
-
8. Eslami AA, Rabiei L, Khayri F, Rashidi Nooshabadi MR, Hosseini
F. Sleep quality and spiritual well-being in hemodialysis patients.
Iran Red Crescent Med J. 2014;16(7):e17155.
-
9. Scherer JS, Combs SA, Brennan F. Sleep disorders, restless
legs syndrome, and uremic pruritus: diagnosis and treatment
of common symptoms in dialysis patients. Am J Kidney Dis.
2017;69(1):117-128.
-
10. Pojatić Đ, Pezerović D, Mihaljević D, Degmečić D. Factors
associated with sleep disorders in patients on chronic hemodialysis
treatment. Seemedj. 2020;4(1):74–86
-
11. Turk AC, Ozkurt S, Turgal E, Basat S, Bozdemir MN, Okyay
GU, et al. The association between the prevalence of restless
leg syndrome, fatigue, and sleep quality in patients undergoing
hemodialysis. Saudi Med J. 2018;39(8):792-798.
-
12. Unruh ML, Buysse DJ, Dew MA, Evans IV, Wu AW, Fink NE, et
al. Sleep quality and its correlates in the first year of dialysis: the
choice study. Clin J Am Soc Nephrol. 2006;1(4):802-810.
-
13. Lichstein KL, Durrence HH, Riedel BW, Taylor DJ, Bush AJ.
Epidemiology of sleep: age, gender, and ethnicity. 1st ed. Mahwah
(NJ): Psychology Press; 2004.
-
14. Caballero-Castañeda L, Flores-Méndez YL, Juárez-Sánchez JO,
García-García P, Hernández-Carmona H, Rodríguez-Flores EA.
Calidad del sueño en pacientes con enfermedad renal crónica en
hemodiálisis [Sleep quality in patients with chronic kidney disease
on hemodialysis]. Rev Med Inst Mex Seguro Soc. 2023;61(2):213-
219.
-
15. Williams SW, Tell GS, Zheng B, Shumaker S, Rocco MV, Sevick
MA. Correlates of sleep behavior among hemodialysis patients:
the KOPE study. Am J Nephrol. 2002;22(1):18-28.
-
16. Lyons OD. Sleep disorders in chronic kidney disease. Nat Rev
Nephrol. 2024;20(10):690-700.
-
17. Ohayon MM. Epidemiological study on insomnia in the general
population. Sleep. 1996;19(Suppl 3):S7-15.
-
18. Kutner NG, Bliwise DL. Restless legs complaint in AfricanAmerican and caucasian hemodialysis patients. Sleep Med.
2002;3(6):497-500.
-
19. Winkelmann J, Schadrack J, Wetter TC, Zieglgänsberger W,
Trenkwalder C. Opioid and dopamine antagonist drug challenges
in untreated restless legs syndrome patients. Sleep Med.
2001;2(1):57-61.
-
20. Earley CJ, Connor JR, Beard JL, Malecki EA, Epstein DK, Allen
RP. Abnormalities inCSF concentrations of ferritin and transferrin
in restless legs syndrome. Neurology. 2000;54(8):1698-1700.