Sitomegalovirus Enfeksiyonuna Bağlı Ciddi Trombositopeni
Abstract
Sitomegalovirüs (CMV) enfeksiyonu immün sistemi normal olanlar bireylerde genellikle asemptomatik seyretmekle birlikte nadiren ciddi klinik tablolar tanımlanmıştır. Sağlıklı erişkinlerde CMV enfeksiyonu sonrası ciddi trombositopeni gelişen vakalar bildirilmiş olmasına rağmen çocuklarda bildirilen vaka sayısı azdır. CMV enfeksiyonuna bağlı trombositopenide tedavide ilk seçenek steroidlerdir, bununla birlikte dirençli vakalarda intravenöz immunglobulin (İVİG) tedavisi oldukça etkili olmaktadır. Biz bu yazıda CMV enfeksiyonu sonrasında trombositopeni gelişen ve İVİG tedavisine dramatik yanıt alınan bir çocuk hastayı sunduk.
Abstract
Cytomegalovirus (CMV) infection is generally asymptomatic in the immunocompetent hosts and rarely defined as a severe clinical situation . However there have been several case reports of trombocytopenia after CMV infections in adults, there are few reports about pediatric cases. The first choice in trombocytopenia related with CMV infections is streroids, in refractory cases intravenous immunoglobulin (IVIG) therapy is very effective. In this article we describe a pediatric patient who has trombocytopenia after CMV infection and be dramatically treated by IVIG therapy.
Keywords
References
- 10. Yaari S, Koslowsky B, Wolf D, Chajek-Shaul T, Hershcovici T. CMV-related thrombocytopenia treated with foscarnet: a case series and review of the literature. Platelets 2010;21:490-5.
- 9. Eisenberg MJ, Kaplan B. Cytomegalovirus-induced thrombocytopenia in an immunocompetent adult. West J Med 1993;158:525-6.
- 8. Wu Z, Zhou J, Wei X, Wang X, Li Y, Peng B, Niu T. The role of Epstein-Barr virus (EBV) and cytomegalovirus (CMV) in immune thrombocytopenia. Hematology 2013;18:295-9.
- 7. Europea Sugioka T, Kubota Y, Wakayama K, Kimura S. Severe steroid-resistant thrombocytopenia secondary to cytomegalovirus infection in an immunocompetent adult. Intern Med 2012;51:1747-50.
- 6. Ichiche M, Fontaine C, Lacor P. Severe thrombocytopenia secondary to cytomegalovirus infection in an immunocompetent adult. Eur J Intern Med 2003;14:56-59.
- 5. Rafailidis PI, Mourtzoukou EG, Varbobitis IC, Falagas ME. Severe cytomegalovirus infection in apparently immunocompetent patients: a systematic review. Virol J 2008;5:47.
- 4. Schleiss MR. Cytomegalovirus in the Neonate: Immune Correlates of Infection and Protection. Clin Dev Immunol 2013;2013:501801.
- 3. Sakata H, Ikegami K, Nagaya K, Shirai M, Maruyama S. Thrombocytopenia caused by acquired cytomegalovirus infection in children. Pediatr Int 1999;41:113-4.
Details
Primary Language
English
Subjects
Health Care Administration
Journal Section
Case Report
Publication Date
August 15, 2016
Submission Date
May 4, 2016
Acceptance Date
-
Published in Issue
Year 2016 Volume: 1 Number: 1