Bir Covid-19 Hastasında Hayatı Tehdit Eden Nadir Bir Mantar Enfeksiyonu

Year 2021, Volume: 6 Issue: 3, 98 - 102, 01.12.2021

Naved Hasan

Abstract

PP1D: JAMR-1046-4326-46
I am reporting a case of an emerging fungal infection, known as invasive/disseminated trichosporonosis, caused by trichosporon asahii, in a Covid-19 patient. After MEDLINE Database, Google Scholar, and PubMed search, I found this to be the first case reported in Saudi Arabia, in a Covid-19 patient. This patient had multiple risk factors, including diabetes mellitus, chronic kidney disease, prolonged intubation, central line/dialysis catheter, an arterial line, need for nasogastric tubes, antibiotics, corticosteroids, cardiovascular disease, last but not the least, Covid-19 itself. This patient continued to deteriorate, despite being on antifungal medications, and developed multi-organ failure, leading to mortality.

Keywords

COVID-19 virüs , invaziv fungal enfeksiyonlar , trikosporon

A rare life threatening fungal infection in a covid-19 patient

Abstract

I am reporting a case of an emerging fungal infection, known as invasive/disseminated trichosporonosis, caused by trichosporon asahii, in a Covid-19 patient. After MEDLINE Database, Google Scholar, and PubMed search, I found this to be the first case reported in Saudi Arabia, in a Covid-19 patient. This patient had multiple risk factors, including diabetes mellitus, chronic kidney disease, prolonged intubation, central line/dialysis catheter, an arterial line, need for nasogastric tubes, antibiotics, corticosteroids, cardiovascular disease, last but not the least, Covid-19 itself. This patient continued to deteriorate, despite being on antifungal medications, and developed multi-organ failure, leading to mortality.

Keywords

COVID-19 virus , invasive fungal Infections , trichosporon

References

• 1. Calabrese F., Pezzuto F., Fortarezza F.et al., Hofman P., Kern I., Panizo A., Jan von der Thusen., Sergei Timofeev., Gregor Gorkiewics., Francesca Lunardi., Pulmonary pathology and COVID-19: lessons from the autopsy. The experience of European Pulmonary Pathologists. Virchows Archiv.359-372(2020) [PMC free article] [PubMed] [Google Scholar]
• 2. Lai C.C., Shih T.P., Ko W.C., Tang H.J., Hsueh P.R. Elsevier B.V.; 2020. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): the epidemic and the challenges. International Journal of Antimicrobial Agents.Int J Antimicrob Agents. 105924 [PMC free article] [PubMed] [Google Scholar]
• 3. Chen N., Zhou M., Dong X., Qu J., Gong F., Han Y.et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020; 395:507–513. [PMC free article] [PubMed] [Google Scholar]
• 4. Rodriguez-Tudela J.L., Alastruey-Izquierdo A., Gago S., Cuenca-Estrella M., León C., Miro J.M., A Nunez Boluda., I Ruiz Camps., A Sole., D W Denning., Burden of serious fungal infections in Spain. Clin Microbiol Infect. 2015; 21:183–189. [PubMed] [Google Scholar]
• 5. de Almeida J.N., Hennequin C. Frontiers Media S.A.; 2016. Invasive trichosporon infection: a systematic review on a re-emerging fungal pathogen. Frontiers in Microbiology, Front Microbiol.2016.01629 [PMC free article] [PubMed] [Google Scholar]
• 6. Lu Q.-B., Jiang W.-L., Zhang X., Li H.-J., Zhang X.-A., Zeng H.-L., Yang G.-L., Rui Li., Fang Li-Qun., Hao Li., Wei Liu., Comorbidities for fatal outcome among the COVID-19 patients: a hospital-based case-control study. J Infect. 2020:159-198. [PMC free article] [PubMed] [Google Scholar]
• 7. Song G., Liang G., Liu W. Fungal co-infections associated with global COVID-19 pandemic: a clinical and diagnostic perspective from china. Mycopathologia. 2020;185:599–606. [PMC free article] [PubMed] [Google Scholar]
• 8. Chagas-Neto T.C., Chaves G.M., Colombo A.L. Update on the genus trichosporon. Mycopathologia. 2008;166:121–132. [PubMed] [Google Scholar]
• 9. Walsh T.J., Groll A., Hiemenz J., Fleming R., Roilides E., Anaissie E. Infections due to emerging and uncommon medically important fungal pathogens. Clin Microbiol Infect. 2004;10:48–66. [PubMed] [Google Scholar]
• 10. Kontoyiannis D.P., Torres H.A., Chagua M., Hachem R., Tarrand J.J., Bodey G.P., Issam I Raad., Trichosporonosis in a tertiary care cancer center: risk factors, changing spectrum and determinants of outcome. Scand J Infect Dis. 2004;36:564–569. [PubMed] [Google Scholar]
• 11. Liao Y., Lu X., Yang S., Luo Y., Chen Q., Yang R. Epidemiology and outcome of Trichosporon Fungemia: a review of 185 reported cases from 1975 to 2014. Open Forum Infect Dis. 2015;2:10.ofv141 [PMC free article] [PubMed] [Google Scholar]