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FİBROMYALJİ HASTALARINDA NÖTROFİL/LENFOSİT ORANI, PLATELET/LENFOSİT ORANI VE ORTALAMA TROMBOSİT HACMİNİN DEĞERLENDİRİLMESİ

Year 2018, Volume: 3 Issue: 1, 1 - 10, 19.04.2018

Abstract


ÖZET




Amaç:
Fibromyalji, nedeni tam olarak bilinmeyen ve kas iskelet sisteminde




yaygın
kas hassasiyeti, ağrı, bazı anatomik noktalarda hassasiyet ile
karakterize




kronik
bir hastalıktır. Çalışmamız fibromyalji hastalarında sistemik




inflamasyonun
bir göstergesi olan Nötrofil-lenfosit oranı(NLR),
Platelet/lenfosit




oranı(PLR)
ve Ortalama trombosit volümünü(MPV) değerlendirmek amacıyla




yapılmıştır.




Yöntem:
Bu çalışmaya Fiziksel Tıp ve Rehabilitasyon polikliğimizde




fibromyalji
tanısı ile takip edilen 25 hasta ve kronik hastalığı olmayan
myalji ile




takip
edilen 25 kontrol hastası alındı.

Her iki grubun dermografik veriler ve




nötrofil,
lenfosit, trombosit, NLR, PLR, MPV yönünden karşılaştırıldı.




Bulgular:

Nötrofil sayısı fibromyalji grubunda kontrol grubuna göre düşük




bulundu(p=0.030).
Lenfosit(p=0.286) ve trombosit(p=0.800) sayısı




NLR(p=0.367),
PLR(p=0.961), MPV(p=0.308) her iki grup arasında




istatistiksel
olarak fark saptanmadı.








Sonuç:
Fibromyalji grubunda nötrofil sayısı kontrol grubuna göre daha
düşük




bulunurken(p=0.03)
; PLR, NLR ve MPV değerlerinde her iki grup arasında




farklılık
saptanmadı.








































References

  • 1. Yunus, Muhammad B. "Fibromyalgia and overlapping disorders: the unifying concept of central sensitivity syndromes." Seminars in arthritis and rheumatism. Vol. 36. No. 6. WB Saunders, 2007.2. Gupta A. Silman AJ. Psychological stress and fibromyalgia: a review of the evidence suggesting a neuroendocrine link. Arthritis Res Ther 2004;6:98-106.
  • 2. Gupta A. Silman AJ. Psychological stress and fibromyalgia: a review of the evidence suggesting a neuroendocrine link. Arthritis Res Ther 2004;6:98-106.
  • 3. Bennett, Robert M., et al. "Criteria for the diagnosis of fibromyalgia: validation of the modified 2010 preliminary American College of Rheumatology criteria and the development of alternative criteria."Arthritis care & research66.9 (2014): 1364-1373.
  • 4. Gur A. Karakoç M, Nas K, et al. Cytokines and depression in cases with fibromyalgia. J Rheumatol 2002; 29: 358-61.
  • 5. Clauw DJ, Chrousos GP. Chronic pain and fatigue syndromes: overlapping clinical and neuroendocrine features and potential pathogenic mechanisms. Neuroimmunomodulation 1997;4:134-53.
  • 6. Lippi, Giuseppe, et al. "Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients." Archives of pathology & laboratory medicine 133.4 (2009): 628-632.
  • 7. Proctor MJ, Morrison DS, Talwar D, Balmer SM, et al. A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study. Eur J Cancer 2011;47:2633-41.
  • 8. İlgün, Erdem, et al. "Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio in Fibromyalgia." European Journal of General Medicine 13.2 (2016): 100-104.
  • 9. Bath, Philip, et al. "Association of mean platelet volume with risk of stroke among 3134 individuals with history of cerebrovascular disease." Stroke 35.3 (2004): 622-626.
  • 10. Horne BD, Anderson JL, John JM, et al. Which white blood cell subtypes predict increased cardiovascular risk? J Am Coll Cardiol 2005;45:1638–43.
  • 11. Kilic, Elif, et al. "Romatoid Artritte Nötrofil/Lenfosit ve Platelet/Lenfosit Oranlarının Değerlendirilmesi." Dicle Medical Journal/Dicle Tip Dergisi 43.2 (2016).
  • 12. Atar, Emel, and Ayhan Aşkın. "Diz osteoartrit hastalarında nötrofil/lenfosit oranı, trombosit/lenfosit oranı ve ortalama trombosit hacminin değerlendirilmesi." (2017): 353-360.
  • 13. Kapsoritakis, Andreas N., et al. "Mean platelet volume: a useful marker of inflammatory bowel disease activity." The American journal of gastroenterology 96.3 (2001): 776-781.
  • 14. Yazici, S., et al. "The platelet indices in patients with rheumatoid arthritis: mean platelet volume reflects disease activity." Platelets21.2 (2010): 122-125.
Year 2018, Volume: 3 Issue: 1, 1 - 10, 19.04.2018

Abstract

References

  • 1. Yunus, Muhammad B. "Fibromyalgia and overlapping disorders: the unifying concept of central sensitivity syndromes." Seminars in arthritis and rheumatism. Vol. 36. No. 6. WB Saunders, 2007.2. Gupta A. Silman AJ. Psychological stress and fibromyalgia: a review of the evidence suggesting a neuroendocrine link. Arthritis Res Ther 2004;6:98-106.
  • 2. Gupta A. Silman AJ. Psychological stress and fibromyalgia: a review of the evidence suggesting a neuroendocrine link. Arthritis Res Ther 2004;6:98-106.
  • 3. Bennett, Robert M., et al. "Criteria for the diagnosis of fibromyalgia: validation of the modified 2010 preliminary American College of Rheumatology criteria and the development of alternative criteria."Arthritis care & research66.9 (2014): 1364-1373.
  • 4. Gur A. Karakoç M, Nas K, et al. Cytokines and depression in cases with fibromyalgia. J Rheumatol 2002; 29: 358-61.
  • 5. Clauw DJ, Chrousos GP. Chronic pain and fatigue syndromes: overlapping clinical and neuroendocrine features and potential pathogenic mechanisms. Neuroimmunomodulation 1997;4:134-53.
  • 6. Lippi, Giuseppe, et al. "Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients." Archives of pathology & laboratory medicine 133.4 (2009): 628-632.
  • 7. Proctor MJ, Morrison DS, Talwar D, Balmer SM, et al. A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study. Eur J Cancer 2011;47:2633-41.
  • 8. İlgün, Erdem, et al. "Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio in Fibromyalgia." European Journal of General Medicine 13.2 (2016): 100-104.
  • 9. Bath, Philip, et al. "Association of mean platelet volume with risk of stroke among 3134 individuals with history of cerebrovascular disease." Stroke 35.3 (2004): 622-626.
  • 10. Horne BD, Anderson JL, John JM, et al. Which white blood cell subtypes predict increased cardiovascular risk? J Am Coll Cardiol 2005;45:1638–43.
  • 11. Kilic, Elif, et al. "Romatoid Artritte Nötrofil/Lenfosit ve Platelet/Lenfosit Oranlarının Değerlendirilmesi." Dicle Medical Journal/Dicle Tip Dergisi 43.2 (2016).
  • 12. Atar, Emel, and Ayhan Aşkın. "Diz osteoartrit hastalarında nötrofil/lenfosit oranı, trombosit/lenfosit oranı ve ortalama trombosit hacminin değerlendirilmesi." (2017): 353-360.
  • 13. Kapsoritakis, Andreas N., et al. "Mean platelet volume: a useful marker of inflammatory bowel disease activity." The American journal of gastroenterology 96.3 (2001): 776-781.
  • 14. Yazici, S., et al. "The platelet indices in patients with rheumatoid arthritis: mean platelet volume reflects disease activity." Platelets21.2 (2010): 122-125.
There are 14 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Makale
Authors

Çağlar Karabaş

Publication Date April 19, 2018
Acceptance Date April 19, 2018
Published in Issue Year 2018 Volume: 3 Issue: 1

Cite

Vancouver Karabaş Ç. FİBROMYALJİ HASTALARINDA NÖTROFİL/LENFOSİT ORANI, PLATELET/LENFOSİT ORANI VE ORTALAMA TROMBOSİT HACMİNİN DEĞERLENDİRİLMESİ. JAMER. 2018;3(1):1-10.