Research Article
ROMATOİD ARTRİTTE METOTREKSAT VE ANTİ-TNF KULLANAN HASTALARDA NÖTROFİL/LENFOSİT , PLATELET/LENFOSİT ORANI VE MPV DEĞERLERİNİN KARŞILAŞTIRILMASI
Abstract
Amaç:Romatoid
artrit nedeni kesin olarak bilinmeyen, eklemlerde yıkım ile giden
otoimmun, kronik, multisistemik bir hastalıktır. Biz bu çalışmada
Romatoid artrit hastalarında metotrexat ve Anti-TNF blokör kullanan
hastalarda NLO,PLO oranlarını ve MPV oranlarını araştırmayı
amaçladık.
Yöntem:
Bu çalışmaya romatoid artrit tanısı almış anti-TNF ve
metotreksat kullanan 24 hasta alındı. Her iki grup dermografik
veriler, MPV, NLR, PLR, CRP ve DAS28 değerleri yönünden
karşılaştırıldı.
Bulgular:
Her iki grup CRP (p:0,451), DAS28 (p:0,977), NLO (p:0,686), PLO
(p:0,371), MPV (p:0,507) açısından istatistiksel olarak benzer
bulundu.
Sonuç:
Romatoid artrit tanısı konmuş anti-TNF ve metotreksat kullanan her
iki hasta grubunda PLR, NLR, MPV, CRP , DAS28 değerleri açısından
fark saptanmadı.
References
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Year 2018,
Volume: 3 Issue: 1, 23 - 28, 19.04.2018
Abstract
References
- 1. Gümüş G: Bağ Dokusu Hastalıkları: Romatid Artrit. Gümüşdiş G, Doğanavşargil E (eds). Klinik Romatoloji, Deniz Matbaası, sf:269-279, İstanbul 1999 2. Mikuls TR, Farrar JT, Bilker WB, Fernandes S, Schumacher HR, Saag KG, Goud epidemio Logy. Results Furm The UK General Piractice Research Database, 1990-1999 Ann Rheum Dis 2005;64 :267-72. 3. McLean L, Becker MA. The pathogenesis of gout. In: Hochberg MC, Silman AJ, Smolen JS et al (eds). Rheumatology. Philadelphia : Mosby 2008:1813-27 . 4. Maini RN, Feldmann M: Immunopathogenesis of rheumatoid arthritis. In Maddison P, Isenberg D, Woo P, Glass D (eds). Oxford Textbook of Rheumatology, Oxford University Press p: 983-1004, 1998. 5. van Riel PL. The development of the disease activity score (DAS) and the disease activity score using 28 joint counts (DAS28). Clin Exp Rheumatol 2014;32:65-74. 6. Yurdakul S. Uzun etkili ilaçlar. Türkiye Klinikleri J Int Med Sci 2006; 2(25):52-59. 7. Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des. 2011;17:47-58. 8. Qin B, Ma N, Tang Q, Wei T, Yang M, Fu H et al. Neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) were useful markers in assessment of inflammatory response and disease activity in SLE patients. Mod Rheumatol. 2015;25:1- 16. 9. Zareifar S, Farahmand Far MR, Golfeshan F, Cohan N. Changes in platelet count and mean platelet volume during infectious and inflammatory disease and their correlation with ESR and CRP. J Clin Lab Anal. 2014;28:245-8. 10. Şahin A, Yetişgin A, Şahin M, Durmaz Y, Cengiz AK. Can mean platelet volume be a surrogate marker of inflammation in rheumatic diseases? West Indian Med J 2015; doi: 10.7727/wimj.2014.202. 11. Mercan R, Bitik B, Tufan A, Bozbulut UB, Atas N, Ozturk MA et al. The association between neutrophil/lymphocyte ratio and disease activity in rheumatoid arthritis and ankylosing spondylitis. J Clin Lab Anal. 2015; doi: 10.1002/jcla.21908. 12. Elif Kilic , Aylin Rezvani, Aybala Erek Toprak ; 43 (2): 241-247 Dicle Medical Journal doi: 10.5798/diclemedj.0921.2016.02.0674 13. Ayhan A,Cukurova Med J 2016;41(3):479-484 ÇUKUROVA ÜNİVERSİTESİ TIP FAKÜLTESİ DERGİSİ DOI: 10.17826/cukmedj.237486
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Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Makale |
| Authors | |
| Publication Date | April 19, 2018 |
| Acceptance Date | April 19, 2018 |
| Published in Issue | Year 2018 Volume: 3 Issue: 1 |