Review

Bee Venom and Its Therapeutic Uses

Volume: 7 Number: 2 December 29, 2024
TR EN

Bee Venom and Its Therapeutic Uses

Abstract

The use of honey and other bee products goes back thousands of years. So that even its therapeutic benefits are mentioned in sacred books such as (Veda, the holy book of India), (Bible, the holy book of Christians) and the Quran. Apiterapy is the use of bee products for medical purposes, which includes honey, royal jelly, propolis, flower pollen, and mainly bee venom, which is known as apitoxin Bee venom consists of at least 18 pharmacologically active compounds including enzymes such as phospholipases, peptide and amino acid compounds such as melittin, which has anti-inflammatory properties. Other properties such as anti-apoptotic and anti-cancer properties have also been mentioned for bee venom. Since, the lethal dose (LD50) of the poison for humans is 2.8 mg/kg per kilogram of body weight, so it is a safe combination for therapeutic purposes. Bee venom has a high potential in the treatment of inflammatory diseases and the central nervous system such as Parkinson's, Alzheimer's, myotrophic sclerosis and various types of cancer. Also, due to its antiviral activity, it has been effective even against the human immunodeficiency virus (HIV). Due to the prevalence of diseases in today's societies, it is inevitable to find new treatment solutions. On the other hand, the drugs used in traditional medicine play an important role in the treatment of diseases. Among these natural substances is bee venom. which should be taken into consideration due to its many therapeutic properties in the treatment of diseases.

Keywords

Bee venom, historical records, therapeutic uses, structure

References

  1. Aarsland, D., Creese, B., Politis, M., Chaudhuri, K. R., Ffytche, D. H., Weintraub, D., & Ballard, C. (2017). Cognitive decline in Parkinson disease. Nature Reviews Neurology, 13(4), 217-231.
  2. Ali, M. A. A. S. M. (2012). Studies on bee venom and its medical uses. Int J Adv Res Technol, 1(2), 69-83.
  3. Aksoz, E., Gocmez, S. S., Sahin, T. D., Aksit, D., Aksit, H., & Utkan, T. (2019). The protective effect of metformin in scopolamine-induced learning and memory impairment in rats. Pharmacological Reports, 71(5), 818-825.
  4. Bachis, A., Cruz, M. I., & Mocchetti, I. (2010). M‐tropic HIV envelope protein gp120 exhibits a different neuropathological profile than T‐tropic gp120 in rat striatum. European Journal of Neuroscience, 32(4), 570-578.
  5. Bond, C. T., Herson, P. S., Strassmaier, T., Hammond, R., Stackman, R., Maylie, J., & Adelman, J. P. (2004). Small conductance Ca2+-activated K+ channel knock-out mice reveal the identity of calcium-dependent afterhyperpolarization currents. Journal of Neuroscience, 24(23), 5301-5306.
  6. Carpena, M., Nuñez-Estevez, B., Soria-Lopez, A., & Simal-Gandara, J. (2020). Bee venom: an updating review of its bioactive molecules and its health applications. Nutrients, 12(11), 3360.
  7. Cherniack, E. P., & Govorushko, S. (2018). To bee or not to bee: The potential efficacy and safety of bee venom acupuncture in humans. Toxicon, 154, 74-78.
  8. de Matos Silva, L. F. C., de Paula Ramos, E. R., Ambiel, C. R., Correia-de-Sá, P., & Alves-Do-Prado, W. (2010). Apamin reduces neuromuscular transmission by activating inhibitory muscarinic M2 receptors on motor nerve terminals. European journal of pharmacology, 626(2-3), 239-243.
  9. Dennis, E. A., Cao, J., Hsu, Y. H., Magrioti, V., & Kokotos, G. (2011). Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention. Chemical reviews, 111(10), 6130-6185.
  10. Eiseman, J. L., Von Bredow, J., & Alvares, A. P. (1982). Effect of honeybee (Apis mellifera) venom on the course of adjuvant-induced arthritis and depression of drug metabolism in the rat. Biochemical pharmacology, 31(6), 1139-1146.
APA
Morovvati, H., Keyhan, H., Koohi, M. K., & Hassan, J. (2024). Bee Venom and Its Therapeutic Uses. Journal of Apitherapy and Nature, 7(2), 65-84. https://doi.org/10.35206/jan.1378226
AMA
1.Morovvati H, Keyhan H, Koohi MK, Hassan J. Bee Venom and Its Therapeutic Uses. J.Apit.Nat. 2024;7(2):65-84. doi:10.35206/jan.1378226
Chicago
Morovvati, Hassan, Haydeh Keyhan, Mohammad Kazem Koohi, and Jalal Hassan. 2024. “Bee Venom and Its Therapeutic Uses”. Journal of Apitherapy and Nature 7 (2): 65-84. https://doi.org/10.35206/jan.1378226.
EndNote
Morovvati H, Keyhan H, Koohi MK, Hassan J (December 1, 2024) Bee Venom and Its Therapeutic Uses. Journal of Apitherapy and Nature 7 2 65–84.
IEEE
[1]H. Morovvati, H. Keyhan, M. K. Koohi, and J. Hassan, “Bee Venom and Its Therapeutic Uses”, J.Apit.Nat., vol. 7, no. 2, pp. 65–84, Dec. 2024, doi: 10.35206/jan.1378226.
ISNAD
Morovvati, Hassan - Keyhan, Haydeh - Koohi, Mohammad Kazem - Hassan, Jalal. “Bee Venom and Its Therapeutic Uses”. Journal of Apitherapy and Nature 7/2 (December 1, 2024): 65-84. https://doi.org/10.35206/jan.1378226.
JAMA
1.Morovvati H, Keyhan H, Koohi MK, Hassan J. Bee Venom and Its Therapeutic Uses. J.Apit.Nat. 2024;7:65–84.
MLA
Morovvati, Hassan, et al. “Bee Venom and Its Therapeutic Uses”. Journal of Apitherapy and Nature, vol. 7, no. 2, Dec. 2024, pp. 65-84, doi:10.35206/jan.1378226.
Vancouver
1.Hassan Morovvati, Haydeh Keyhan, Mohammad Kazem Koohi, Jalal Hassan. Bee Venom and Its Therapeutic Uses. J.Apit.Nat. 2024 Dec. 1;7(2):65-84. doi:10.35206/jan.1378226