Water Extract of Propolis Might be Safer to Use During Pregnancy than Ethanol Extract

Year 2018, Volume: 1 Issue: 3 - 2nd Propolis Conference Special Issue, 43 - 43, 08.12.2018

Al Mukhlas Fıkrı Ahmad Sulaeman Sri Anna Marlıyatı Mokhamad Fahrudın

Abstract

Propolis is a natural product that has many
health benefits. This study was the first investigation examining the effect of
propolis administration on pregnancy. Pregnant mice were used as experimental
animals (n = 25) divided in five groups. They were control group (Tween 80 1%),
low (380 mg/ kg b.w) and high (1400 mg/ kg b.w) dose of ethanol extract of
propolis (EEP), low (380 mg/ kg b.w) and high (1400 mg/kg b.w) dose of water
extract of propolis (WEP). Propolis was administered from 0 to 18 days of gestational
age. The results showed that high dose of EEP significantly reduced weight and
crown-rump of fetuses and increased the amount of resorption (p<0.05).
However, low dose of EEP, low and high dose of WEP did not affect weight and
crown-rump length of fetuses compare to control group. Low dose of EEP, low and
high dose of WEP significantly reduced number of resorption compare to high
dose of EEP. There was no difference in liver and kidney weight, serum ureum,
creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST)
and maternal weight gain. No significant difference also was found in placental
weight, litter size, number of dead fetuses, embryo mortality before and after
implantation. The results of this study indicate that WEP might be safer to use
during pregnancy than EEP.

Acknowledgement: Thanks to Ministry of Research, Technology and Higher Education,
Republic of Indonesia for research grant through scheme Master and Doctoral
Program of Excellent Graduate

Keywords

Water Extract, Ethanol Extract, Propolis

References

• 1. Fikri AM, Sulaeman A, Marliyati SA, Fahrudin M. Antiemetic Activity of Trigona spp. Propolis from Three Provinces of Indonesia with Two Methods of Extraction. Pharmacog J. 2018;10(1):120-2.