Analysis of Structural Defects Caused by Gamma Radiation on Amitriptyline Hydrochloride Through Electron Paramagnetic Resonance (EPR) and Simulation Technique

Year 2024, Volume: 3 Issue: 1, 27 - 35, 27.06.2024

Fırat Akbalık

https://doi.org/10.5281/zenodo.12174823

Abstract

In this study, the suitable of usage as a dosimetric material gamma-irradiated Amitriptyline Hydrochloride, which is used in treatment of symptoms of depression diseases, was studied with EPR spectroscopy. Signal fading, microwave saturation behavior and dose-response curve information were investigated at room temperature. Moreover, the drug sample was also measured at different temperature ranges, EPM signal was not detected in unirradiated samples. The spectroscopic properties of radical induced by irradiation were also determined by spectrum simulation.

Keywords

EPR, Dosimetry, Gamma irradiation

Gama Radyasyonun Amitriptyline Hydrochloride Üzerinde Oluşturduğu Yapısal Bozuklukların Elektron Paramanyetik Rezonans (EPR) ve Simülasyon Tekniği ile İncelenmesi

Abstract

Bu çalışmada, depresyon semptomlarının tedavisinde sıkça kullanılan ilaç etkin maddesi Amitriptyline Hydrochloride gama radyasyonuna maruz bırakılarak oluşan paramanyetik bozukluk EPR spektroskopisi ile çalışılmıştır. Örneğin, dozimetrik malzeme olarak kullanıma uygunluğu, radikal sönüm bilgileri, mikrodalga güç değerlerinde doyum bilgileri ve doz-cevap eğrisi oda sıcaklığında araştırılmıştır. İlaç örneği farklı sıcaklık aralıklarında da ölçülmüştür. Ayrıca gama radyasyonuna maruz bırakılmayan örnekte EPS sinyali gözlenmemiştir. Spektrum simülasyonu (benzetişimi) yapılarak radyasyon sonucunda oluşan radikalin spektroskopik özellikleri belirlenmiştir.

Keywords

EPR, Dozimetri, Gama ışınlama

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