Exopolysaccharide from Rhodococcus pyridinivorans ZZ47 Strain: Evaluation of Biological Activity and Toxicity

Aylin Taşkaya; Nur Ceyhan Güvensen; Cem Güler; Ebru Şancı; Ülkü Karabay

doi:10.56430/japro.1307611

EN

Exopolysaccharide from Rhodococcus pyridinivorans ZZ47 Strain: Evaluation of Biological Activity and Toxicity

Abstract

Microbial polysaccharides are extracellular polymeric macromolecules excreted in microorganisms. These are widely used in food, cosmetic and pharmaceutical industries. One of them, exopolysaccharides (EPS), plays important role against the factors such as phage attack, antibiotics, toxic compounds or osmotic stress. Recently, this natural polymer has received great attention due to their therapeutic potential. The purpose of the study was to evaluate biological activity and potential toxicity of EPS from Rhodococcus pyridinivorans ZZ47 strain isolated from nature. EPS has no genotoxic effect on Salmonella typhimurium TA98, TA102, and TA1537 strains by Ames Test. No death occurred with single dose oral toxicity test of EPS and LD50 value of it is calculated by >2000 mg/kg in mice. The EPS showed antibiofilm activity on different bacteria. In addition, EPS demonstrated dose-dependent anti-angiogenic properties by HET-CAM test. In conclusion, the isolated EPS has antioxidant activity with no genotoxicity and the biological activities of the polymer indicated that it may be suitable for use in different sectors and industrial applications.

Keywords

Acute toxicity , Anti-angiogenic activity , Antibiofilm activity , Exopolysaccharide , Genotoxicity , Rhodococcus pyridinivorans

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Details

Primary Language

English

Subjects

Water Resources and Water Structures

Journal Section

Research Article

Authors

Aylin Taşkaya
0000-0002-6221-3365
Türkiye

Nur Ceyhan Güvensen ^*
0000-0001-8753-2664
Türkiye

Cem Güler
0000-0003-4945-4794
Türkiye

Ebru Şancı
0000-0002-0525-9690
Türkiye

Ülkü Karabay
0000-0002-7483-0184
Türkiye

Publication Date

June 30, 2023

Submission Date

June 1, 2023

Acceptance Date

June 19, 2023

Published in Issue

Year 2023 Volume: 4 Number: 1

DOI

https://doi.org/10.56430/japro.1307611

IZ

https://izlik.org/JA93NF35SZ

APA

Taşkaya, A., Ceyhan Güvensen, N., Güler, C., Şancı, E., & Karabay, Ü. (2023). Exopolysaccharide from Rhodococcus pyridinivorans ZZ47 Strain: Evaluation of Biological Activity and Toxicity. Journal of Agricultural Production, 4(1), 63-71. https://doi.org/10.56430/japro.1307611