EBER In Situ Hybridization Experience In Hodgkin Lymphoma

Year 2021, , 201 - 204, 20.09.2021

Gulen Gul , Mehmet Ali Özcan , Sermin Özkal

https://doi.org/10.30621/jbachs.985629

Cited By: 1

Abstract

Purpose
Several studies suggest that the relation of Epstein-Barr virus (EBV) and Hodgkin lymphoma (HL). EBV and HL associations are reported at rates ranging from 20% to 100% that varies nationally and regionally. In this study; in the case of Hodgkin's lymphoma, the presence of EBV encoded RNA (EBER) by in situ hybridization method and it’s distribution according to histopathological subtypes were investigated.
Methods
We investigated the presence of EBV in Hodgkin Lymphoma diagnosed 107 adult cases between 2013 and 2017, which chromogenic in situ hybridization with EBV RNA probe has been in routine use were evaluated retrospectively with pathology reports.
Results
There were 69 males and 38. Nodular Sclerosis Classical Hodgkin Lymphoma (NSCHL) was the most common (63 cases, 58,9%) followed by Mixed Cellularity Classical Hodgkin Lymphoma (MCCHL) (23 cases,21,5%). EBV was expressed in 40 cases (45,4%). High EBV association was found with NSCHL (50%) and MCCHL (48%). None of NLPHL was positive with EBER.
Conclusion
In our series NSCHL is the most common histologic subtype and has higher percentages of EBV positivity as reported in developed countries. Our study has the largest series of patients investigating the relationship between HL and EBER in our country. For further comments more studies, particularly from Turkey, are needed to determine the actual epidemiological pattern of HL in the region and to define the role of EBV in HL.

Keywords

EBER, EBV, Hodgkin Lymphoma

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