Autologue Skin Microbiota Transplantation In Cats With Primary/Secondary Skin Lesions: Route For Substituting Cutaneous Integumentary System Against Allergy
Abstract
Feline integumentary environment and its biogeography might display microbial dysbiosis with an enrichment of specifical pathogens, which have also been implicated in dermatological issues in cats. Primary and secondary skin lesions might be frequently observed in cats which are quite commonly underdiagnosed causing core skin microbiome default. Moreover recent researches supported the participation of the skin microbiome in several dermatological issues among cats, there has been knowledge gaps for natural treatment. To this sense we aimed to substitute diseased and perturbated skin microbiome to those of healthy adjacent microbiogeography by use of Nivea Refining Clear-Up Strips (Ni-RcUs) in cats with primary/secondary skin lesions. Briefly this autologue skin microbiota transplantation (a-SmT) technique instead of what have been used properly as heterologue skin microbiota transplantation (h-SmT) by the same reserachers group, involved transfer of cutaneous microbiome from adjacent healthy tissue to pertubated skin of same case by use of Ni-RcUs. In a total of 50 cats with a history of non-seasonal pruritus, miliary dermatitis, eosinophilic dermatitis, alopecia or excoriation, following tentative diagnosis of allergy, the severity and distribution of clinical dermatological lesions were assessed using SCORFAD (SCORing Feline Allergic Dermatitis) system. To this sense a-SmT has been performed to all 50 cats with a well established and performed methodology (by the same group of investigators of this manuscript), in which adjacent healthy tissue microbiome was substituted and replaced to diseased skin. Following completion of a-SmT there was significant clinical recovery in which mean excoriation, miliary dermatitis, eosinophilic dermatitis and self-induced alopecia scores were totally decreased [2.50 vs. 0.74, 1.52 vs. 0.42, 0.22 vs. 0.00 and 3.48 vs. 0.74, before and after treatment, respectively] (p <0.001). Moreover mean total cumulative SCORFAD values were deemed significantly (p <0.001) decreased [7,63 vs. 2.06]. In conclusion this natural route of unmatched treatment modality should replace, previously used old fashioned drug trials of immunosuppressive origin.
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Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Sciences (Other) |
| Journal Section | Research Article |
| Authors | |
| Submission Date | September 19, 2025 |
| Acceptance Date | January 7, 2026 |
| Publication Date | January 21, 2026 |
| IZ | https://izlik.org/JA55JG43DW |
| Published in Issue | Year 2026 Issue: 58 |
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Dokuz Eylül Üniversitesi, Müh.-Mim. Fakültesi, Çevre Mühendisliği Bölümü'nden mezun olmuştur. Yüksek lisans ve doktorasını ABD'nde tamamlamıştır. Uzmanlık alanı, hava kirliliği ve kontrolü üzerinedir. Özellike kalıcı organik kirleticiler (KOK'ler) üzerine araştırmalarını devam ettirmektedir. Halen Bursa Uludağ Üniversitesi, Mühendislik Fakültesi, Çevre Mühendisliği Bölümü'nde öğretim üyesidir.
Danka Bukvicki gained her master and PhD in Biology at the Faculty of Biology University of Belgrade (FBUB). She is a Senior Research Associate at the Department of Morphology and Systematics of Plants, FBUB. Postdoctoral studies in phytochemistry of liverworts and medicinal plants she accomplished at the Tokushima Bunri University (TBU), Japan, the University of Bologna(UNIBO), Department of Agricultural and Food Sciences (DISTAL), and Chemodiversity Research Group, University of Vienna, Austria. Her research interests are applied botany, medicinal and aromatic plants, bioactivity of natural compounds, food microbiology, food technology and phytochemistry. Dr Bukvicki published more than 40 scientific publications in peer-reviewed international journals. She is a member of the editorial board of 2 international scientific journals. She is engaged as a coordinator in international research project (UNDP). Danka has supervised a few national and international master and bachelor students. She is a member of the Phytochemical Society of Asia (PCA) since 2015 and a member of the Serbian Biological Society, since 2011.
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