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Mean trombosit volume in patients with retinopathy of prematurity

Year 2014, , 276 - 279, 01.06.2014
https://doi.org/10.5799/ahinjs.01.2014.02.0402

Abstract

Objective: We aimed to evaluate the mean platelet volume (MPV) in patients with retinopathy of prematurity (ROP) with respect to development of type 1 ROP Methods: The medical records of the premature infants were evaluated. Babies with a birth weight under 1500 g and a gestational age under 32 weeks were enrolled to the study. Birth weight, gestational age, onset and grade of retinopathy, presence of plus disease were analyzed. At the time of type 1 ROP diagnosis, blood samples were obtained. In the patients without type 1 ROP the blood samples were also obtained at similar gestational age. Hemoglobin, hematocrit, platelet count, and MPV results were recorded. Results: Sixty-three infants were studied. 22 of them had type 1 ROP and 41 had not developed type 1 ROP. The mean gestational age and the mean birth weight between groups were not statistically significant. The mean MPV values in patients with type 1 ROP and without type 1 ROP was 9,1±2,0 fL and 9,4±1,8 fL, respectively (p=0.61). Conclusion: The results demonstrated that MPV values were not associated with severity of ROP in our study population. J Clin Exp Invest 2014; 5 (2): 443-446

References

  • Stout AU, Stout JT. Retinopathy of prematurity. Pediatr Clin N Am 2003;50:77-87.
  • Shohat M, Reisner SH, Kricler R Nissenkorn I, Yassur Y, Ben-Sira I. Retinopathy of prematurity: incidence and risk factors. Pediatrics 1983;72:159-163.
  • Cil H, Yavuz C, Islamoglu Y, et al. Trombosit count and mean trombosit volume in patients with in-hospital deep venous thrombosis. Clin Appl Thromb Hemost 2012;18:650-653.
  • Arikanoglu A, Yucel Y, Acar A, et al. The relationship of the mean platelet volume and C-reactive protein lev- els with mortality in ischemic stroke patients. Eur Rev Med Pharmacol Sci 2013;17:1774-1777.
  • Şahin A, Şahin M, Yüksel H, et al. The mean platelet volume in patients with retinal vein occlusion. J Oph- thalmol. 2013;2013:236371.
  • Türkcü FM, Yüksel H, Sahin A, et al. Mean platelet vol- ume in pseudoexfoliation syndrome and glaucoma. Eur J Ophthalmol 2014;24:71-75.
  • Türkcü FM, Cingü AK, Yüksel H, et al. Mean plate- let volume in ocular Behçet’s disease. Sci World J 2013;2013:215912.
  • Giles H, Smith RE, Martin JF. Trombosit glycoprotein IIb-IIIa and size are increased in acute myocardial in- farction. Eur J Clin Invest 1994;24:69-72.
  • Haver VM, Gear AR. Functional fractionation of trom- bosits. J Lab Clin Med 1981;97:187-204.
  • Early Treatment For Retinopathy of Prematurity Co- operative Group. Revised indications for the treat- ment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomized trial. Arch Ophthalmol 2003;121:1684-1694.
  • Ekici B, Erkan AF, Alhan A, et al. Is mean platelet vol- ume associated with the angiographic severity of cor- onary artery disease? Kardiol Pol 2013;71:832-838.
  • Selimoğlu-Şen H, Abakay Ö, Taylan M et al. The im- portance of mean platelet volume in early mortality of pulmonary embolism. J Clin Exp Invest 2013;4: 298- 301
  • Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibri- nolysis 1996;7:157-161.
  • Onder HI, Kilic AC, Kaya M, et al. Relation be- tween platelet indices and branch retinal vein occlu- sion in hypertensive patients. Indian J Ophthalmol 2013;61:160-162.
  • Ateş O, Kiki İ, Bilen H, et al. Association of mean trom- bosit volume with the degree of retinopathy in patients with diabetes mellitus. Eur J General Med 2009: 6;99- 102.
  • Ayhan-Tuzcu E, Arıca S, Ilhan N, et al. Relationship between mean trombosit volume and retinopathy in patients with type 2 diabetes mellitus. Graefes Arch Clin Exp Ophthalmol 2014;252:237-240.
  • Koz C, Turkcu F, Gurbuz O, et al. Endothelial function and novel vascular risk factors in pseudoexfoliation syndrome.Turkiye Klinikleri J Medi Sci 2009;29:1510- 1516.
  • Ricart JM, España F, Navarro S, et al. Mean plate- let volume does not seem to relate to thrombosis or posterior uveitis in Behçet’s disease. Clin Hemorheol Microcirc 2013;54:51-57.
  • Cekmez F, Tanju IA, Canpolat FE, et al. Mean platelet volume in very preterm infants: a predictor of morbidi- ties? Eur Rev Med Pharmacol Sci 2013;17:134-137.
  • Mataftsi A, Dimitrakos SA, Adams GG. Mediators involved in retinopathy of prematurity and emerging therapeutic targets. Early Hum Dev 2011;87:683-690.
  • Gunsilius E, Petzer AL, Gastl G. Vascular endothelial growth factor platelet counts and renal cancer. Lancet 1999;353:2247.
  • Gunsilius E, Gastl G. Platelets and VEGF blood levels in cancer patients. Br J Cancer 1999;81:185-186.
  • Mutlu H, Berk V, Karaca H, et al. Treatment regimen with bevacizumab decreases mean platelet volume in patients with metastatic colon cancer. Clin Appl Thromb Hemost 2012;18:546-548.

Mean trombosit volume in patients with retinopathy of prematurity

Year 2014, , 276 - 279, 01.06.2014
https://doi.org/10.5799/ahinjs.01.2014.02.0402

Abstract

Amaç: Bu çalışmada prematüre retinopatisi (PR) olan hastalarda tip 1 PR gelişen ve gelişmeyen hastaların ortalama trombosit hacmi (OTH) karşılaştırılmıştır. Yöntemler: Çalışma prematüre yeni doğanların hastane kayıtları incelenerek yapılmıştır. 1500 gr ağırlık altında ve doğum haftası 32 haftadan küçük olan bebekler bu çalışmaya dahil edilmiştir. Doğum ağırlıkları, doğum haftası, retinopatinin evresi, artı hastalık varlığı araştırılmıştır. Tip 1 PR tanısı koyulduğu zaman hastalardan kan alınmıştır. Tip 1 PR tanısı almayan hastalardan da benzer gestasyonel yaşlarda kan alınmıştır. Tam kan sayımında; hemoglobin, hematokrit, trombosit sayısı ve OTH değerleri kaydedilmiştir. Bulgular: Altmış üç PR\'li hasta bu çalışmaya dahil edildi. Bu hastaların 22 tanesinde tip 1 PR saptanırken, 41 tanesinde saptanmadı. Ortalama doğum haftası ve doğum ağırlığı gruplar arasında istatistiksel farklılık saptanmadı. Ortalama OTH tip 1 PR gelişen olgularda 9,1±2,0 fL iken tip 1 PR gelişmeyen olgularda 9,4±1,8 fL idi (p=0,61) Sonuçlar: Çalışmamızda OTH değerleri tip 1 PR gelişen ve gelişmeyen PR\'li hastalarda farklı saptanmamıştır.

References

  • Stout AU, Stout JT. Retinopathy of prematurity. Pediatr Clin N Am 2003;50:77-87.
  • Shohat M, Reisner SH, Kricler R Nissenkorn I, Yassur Y, Ben-Sira I. Retinopathy of prematurity: incidence and risk factors. Pediatrics 1983;72:159-163.
  • Cil H, Yavuz C, Islamoglu Y, et al. Trombosit count and mean trombosit volume in patients with in-hospital deep venous thrombosis. Clin Appl Thromb Hemost 2012;18:650-653.
  • Arikanoglu A, Yucel Y, Acar A, et al. The relationship of the mean platelet volume and C-reactive protein lev- els with mortality in ischemic stroke patients. Eur Rev Med Pharmacol Sci 2013;17:1774-1777.
  • Şahin A, Şahin M, Yüksel H, et al. The mean platelet volume in patients with retinal vein occlusion. J Oph- thalmol. 2013;2013:236371.
  • Türkcü FM, Yüksel H, Sahin A, et al. Mean platelet vol- ume in pseudoexfoliation syndrome and glaucoma. Eur J Ophthalmol 2014;24:71-75.
  • Türkcü FM, Cingü AK, Yüksel H, et al. Mean plate- let volume in ocular Behçet’s disease. Sci World J 2013;2013:215912.
  • Giles H, Smith RE, Martin JF. Trombosit glycoprotein IIb-IIIa and size are increased in acute myocardial in- farction. Eur J Clin Invest 1994;24:69-72.
  • Haver VM, Gear AR. Functional fractionation of trom- bosits. J Lab Clin Med 1981;97:187-204.
  • Early Treatment For Retinopathy of Prematurity Co- operative Group. Revised indications for the treat- ment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomized trial. Arch Ophthalmol 2003;121:1684-1694.
  • Ekici B, Erkan AF, Alhan A, et al. Is mean platelet vol- ume associated with the angiographic severity of cor- onary artery disease? Kardiol Pol 2013;71:832-838.
  • Selimoğlu-Şen H, Abakay Ö, Taylan M et al. The im- portance of mean platelet volume in early mortality of pulmonary embolism. J Clin Exp Invest 2013;4: 298- 301
  • Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibri- nolysis 1996;7:157-161.
  • Onder HI, Kilic AC, Kaya M, et al. Relation be- tween platelet indices and branch retinal vein occlu- sion in hypertensive patients. Indian J Ophthalmol 2013;61:160-162.
  • Ateş O, Kiki İ, Bilen H, et al. Association of mean trom- bosit volume with the degree of retinopathy in patients with diabetes mellitus. Eur J General Med 2009: 6;99- 102.
  • Ayhan-Tuzcu E, Arıca S, Ilhan N, et al. Relationship between mean trombosit volume and retinopathy in patients with type 2 diabetes mellitus. Graefes Arch Clin Exp Ophthalmol 2014;252:237-240.
  • Koz C, Turkcu F, Gurbuz O, et al. Endothelial function and novel vascular risk factors in pseudoexfoliation syndrome.Turkiye Klinikleri J Medi Sci 2009;29:1510- 1516.
  • Ricart JM, España F, Navarro S, et al. Mean plate- let volume does not seem to relate to thrombosis or posterior uveitis in Behçet’s disease. Clin Hemorheol Microcirc 2013;54:51-57.
  • Cekmez F, Tanju IA, Canpolat FE, et al. Mean platelet volume in very preterm infants: a predictor of morbidi- ties? Eur Rev Med Pharmacol Sci 2013;17:134-137.
  • Mataftsi A, Dimitrakos SA, Adams GG. Mediators involved in retinopathy of prematurity and emerging therapeutic targets. Early Hum Dev 2011;87:683-690.
  • Gunsilius E, Petzer AL, Gastl G. Vascular endothelial growth factor platelet counts and renal cancer. Lancet 1999;353:2247.
  • Gunsilius E, Gastl G. Platelets and VEGF blood levels in cancer patients. Br J Cancer 1999;81:185-186.
  • Mutlu H, Berk V, Karaca H, et al. Treatment regimen with bevacizumab decreases mean platelet volume in patients with metastatic colon cancer. Clin Appl Thromb Hemost 2012;18:546-548.
There are 23 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Harun Yüksel This is me

Alparslan Şahin This is me

Muhammed Şahin This is me

Fatih Mehmet Türkcü This is me

Yasin Çınar This is me

Zeynep Gürsel-özkurt This is me

Ümit Karaalp This is me

Ünal Uluca This is me

İhsan Çaça This is me

Publication Date June 1, 2014
Published in Issue Year 2014

Cite

APA Yüksel, H., Şahin, A., Şahin, M., Türkcü, F. M., et al. (2014). Mean trombosit volume in patients with retinopathy of prematurity. Journal of Clinical and Experimental Investigations, 5(2), 276-279. https://doi.org/10.5799/ahinjs.01.2014.02.0402
AMA Yüksel H, Şahin A, Şahin M, Türkcü FM, Çınar Y, Gürsel-özkurt Z, Karaalp Ü, Uluca Ü, Çaça İ. Mean trombosit volume in patients with retinopathy of prematurity. J Clin Exp Invest. June 2014;5(2):276-279. doi:10.5799/ahinjs.01.2014.02.0402
Chicago Yüksel, Harun, Alparslan Şahin, Muhammed Şahin, Fatih Mehmet Türkcü, Yasin Çınar, Zeynep Gürsel-özkurt, Ümit Karaalp, Ünal Uluca, and İhsan Çaça. “Mean Trombosit Volume in Patients With Retinopathy of Prematurity”. Journal of Clinical and Experimental Investigations 5, no. 2 (June 2014): 276-79. https://doi.org/10.5799/ahinjs.01.2014.02.0402.
EndNote Yüksel H, Şahin A, Şahin M, Türkcü FM, Çınar Y, Gürsel-özkurt Z, Karaalp Ü, Uluca Ü, Çaça İ (June 1, 2014) Mean trombosit volume in patients with retinopathy of prematurity. Journal of Clinical and Experimental Investigations 5 2 276–279.
IEEE H. Yüksel, A. Şahin, M. Şahin, F. M. Türkcü, Y. Çınar, Z. Gürsel-özkurt, Ü. Karaalp, Ü. Uluca, and İ. Çaça, “Mean trombosit volume in patients with retinopathy of prematurity”, J Clin Exp Invest, vol. 5, no. 2, pp. 276–279, 2014, doi: 10.5799/ahinjs.01.2014.02.0402.
ISNAD Yüksel, Harun et al. “Mean Trombosit Volume in Patients With Retinopathy of Prematurity”. Journal of Clinical and Experimental Investigations 5/2 (June 2014), 276-279. https://doi.org/10.5799/ahinjs.01.2014.02.0402.
JAMA Yüksel H, Şahin A, Şahin M, Türkcü FM, Çınar Y, Gürsel-özkurt Z, Karaalp Ü, Uluca Ü, Çaça İ. Mean trombosit volume in patients with retinopathy of prematurity. J Clin Exp Invest. 2014;5:276–279.
MLA Yüksel, Harun et al. “Mean Trombosit Volume in Patients With Retinopathy of Prematurity”. Journal of Clinical and Experimental Investigations, vol. 5, no. 2, 2014, pp. 276-9, doi:10.5799/ahinjs.01.2014.02.0402.
Vancouver Yüksel H, Şahin A, Şahin M, Türkcü FM, Çınar Y, Gürsel-özkurt Z, Karaalp Ü, Uluca Ü, Çaça İ. Mean trombosit volume in patients with retinopathy of prematurity. J Clin Exp Invest. 2014;5(2):276-9.