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Transient normoprolactinemic galactorrhea induced by fluoxetine

Year 2013, , - , 01.03.2013
https://doi.org/10.5799/ahinjs.01.2013.01.0243

Abstract

Hormonal side effects of antidepressants are infrequent. Galactorrhea is rarely reported among antidepressant related side effects. Antidepressants can directly stimu­late postsynaptic 5- Hydroxytryptamine (5-HT) receptors in the hypothalamus or indirectly inhibit the tuberoinfun­dibular dopaminergic neurons through 5-HT, which may increase prolactin levels and later cause galactorrhea. However, galactorrhea may develop despite normal pro­lactin levels during antidepressant treatment. We present a case of normoprolactinemic galactorrhea in a woman, related with fluoxetine treatment. This report highlights the presence of unidentified mechanisms of selective serotonin reuptake inhibitor induced galactorrhea. J Clin Exp Invest 2013; 4 (1): 105-106

References

  • Bostwick JR, Guthrie SK, Ellingrod VL. Antipsychot- ic-induced hyperprolactinemia. Pharmacotherapy 2009;29 :64-73.
  • Anand VS. Clomipramine-induced galactorrhea and amenorrhea. Br J Psychiatry 1985;147:87-88.
  • Gülsün M, Evrensel A, Verim S. Galactorrhea during escitalopram treatment: A case report Bulletin of Clical Psychopharmacology 2006;16:39-41.
  • Nicholas L, Dawkins K, Golden RN. Psychoneuroen- docrinology of depression. Prolactin. Psychiatr Clin North Am 1998;21:341-358.
  • Arya DK. Extrapyramidal symptoms with selec- tive serotonin reuptake inhibitors. Br J Psychiatry 1994;165:728-733.
  • Gulsun M, Algul A, Semiz UB, et al. A case with eupro- lactinemic galactorrhea induced by escitalopram. Int J Psychiatry Med 2007;37:275-278.
  • Belli H, Vardar MK, Yesilyurt S, et al. Citalopram related euprolactinaemic galactorrhoea: a case report. West Indian Med J 2010;59:100-101.
  • Peterson MC. Reversible galactorrhea and prolactin elevation related to fluoxetine use. Mayo Clin Proc 2001;76:215-216.
  • Meltzer H, Bastani B, Jayathilake K, Maes M. Fluox- etine, but not tricyclic antidepressants, potentiates the 5-hydroxytryptophan-mediated increase in plasma cortisol and prolactin secretion in subjects with ma- jor depression or with obsessive-compulsive disorder. Neuropsychopharmacology 1997;17:1-11.
  • Haefliger T, Bonsack C. Atypical antipsychotics and sexual dysfunction: five case-reports associated with risperidone. Encephale 2006;32:97-105.

Fluoksetine bağlı, geçici normoprolaktinemik galaktore

Year 2013, , - , 01.03.2013
https://doi.org/10.5799/ahinjs.01.2013.01.0243

Abstract

Antidepresanlara bağlı hormonal yan etkiler sık görülme­mektedir. Galaktore, antidepresanlara bağlı yan etkiler arasında nadiren bildirilmiştir. Antidepresanlar, hipotala­mustaki postsinaptik 5-Hidroksitriptamin (5-HT) reseptör­lerini doğrudan uyararak veya tuberoinfindibuler dopami­nerjik nöronları 5-HT üzerinden dolaylı olarak inhibe ede­rek prolaktin seviyelerinde artışa ve sonuçta galaktoreye neden olabilirler. Ancak antidepresan tedavisi sırasında normal prolaktin seviyelerine rağmen galaktore gelişebilir. Bu çalışmada fluoksetin tedavisi ile ilişkili normoprolakti­nemik galaktore gelişen bir kadın olgu sunulacaktır. Bu olgu sunumu ile selektif serotonin gerialım inhibitörlerine bağlı galaktorenin tanımlanmamış mekanizmalarının var­lığı üzerine vurgu yapılacaktır.

References

  • Bostwick JR, Guthrie SK, Ellingrod VL. Antipsychot- ic-induced hyperprolactinemia. Pharmacotherapy 2009;29 :64-73.
  • Anand VS. Clomipramine-induced galactorrhea and amenorrhea. Br J Psychiatry 1985;147:87-88.
  • Gülsün M, Evrensel A, Verim S. Galactorrhea during escitalopram treatment: A case report Bulletin of Clical Psychopharmacology 2006;16:39-41.
  • Nicholas L, Dawkins K, Golden RN. Psychoneuroen- docrinology of depression. Prolactin. Psychiatr Clin North Am 1998;21:341-358.
  • Arya DK. Extrapyramidal symptoms with selec- tive serotonin reuptake inhibitors. Br J Psychiatry 1994;165:728-733.
  • Gulsun M, Algul A, Semiz UB, et al. A case with eupro- lactinemic galactorrhea induced by escitalopram. Int J Psychiatry Med 2007;37:275-278.
  • Belli H, Vardar MK, Yesilyurt S, et al. Citalopram related euprolactinaemic galactorrhoea: a case report. West Indian Med J 2010;59:100-101.
  • Peterson MC. Reversible galactorrhea and prolactin elevation related to fluoxetine use. Mayo Clin Proc 2001;76:215-216.
  • Meltzer H, Bastani B, Jayathilake K, Maes M. Fluox- etine, but not tricyclic antidepressants, potentiates the 5-hydroxytryptophan-mediated increase in plasma cortisol and prolactin secretion in subjects with ma- jor depression or with obsessive-compulsive disorder. Neuropsychopharmacology 1997;17:1-11.
  • Haefliger T, Bonsack C. Atypical antipsychotics and sexual dysfunction: five case-reports associated with risperidone. Encephale 2006;32:97-105.
There are 10 citations in total.

Details

Primary Language Turkish
Journal Section Case Report
Authors

Fatih Canan This is me

Unsal Aydinoglu This is me

Gjergji Sinani This is me

Publication Date March 1, 2013
Published in Issue Year 2013

Cite

APA Canan, F., Aydinoglu, U., & Sinani, G. (2013). Fluoksetine bağlı, geçici normoprolaktinemik galaktore. Journal of Clinical and Experimental Investigations, 4(1). https://doi.org/10.5799/ahinjs.01.2013.01.0243
AMA Canan F, Aydinoglu U, Sinani G. Fluoksetine bağlı, geçici normoprolaktinemik galaktore. J Clin Exp Invest. March 2013;4(1). doi:10.5799/ahinjs.01.2013.01.0243
Chicago Canan, Fatih, Unsal Aydinoglu, and Gjergji Sinani. “Fluoksetine bağlı, geçici Normoprolaktinemik Galaktore”. Journal of Clinical and Experimental Investigations 4, no. 1 (March 2013). https://doi.org/10.5799/ahinjs.01.2013.01.0243.
EndNote Canan F, Aydinoglu U, Sinani G (March 1, 2013) Fluoksetine bağlı, geçici normoprolaktinemik galaktore. Journal of Clinical and Experimental Investigations 4 1
IEEE F. Canan, U. Aydinoglu, and G. Sinani, “Fluoksetine bağlı, geçici normoprolaktinemik galaktore”, J Clin Exp Invest, vol. 4, no. 1, 2013, doi: 10.5799/ahinjs.01.2013.01.0243.
ISNAD Canan, Fatih et al. “Fluoksetine bağlı, geçici Normoprolaktinemik Galaktore”. Journal of Clinical and Experimental Investigations 4/1 (March 2013). https://doi.org/10.5799/ahinjs.01.2013.01.0243.
JAMA Canan F, Aydinoglu U, Sinani G. Fluoksetine bağlı, geçici normoprolaktinemik galaktore. J Clin Exp Invest. 2013;4. doi:10.5799/ahinjs.01.2013.01.0243.
MLA Canan, Fatih et al. “Fluoksetine bağlı, geçici Normoprolaktinemik Galaktore”. Journal of Clinical and Experimental Investigations, vol. 4, no. 1, 2013, doi:10.5799/ahinjs.01.2013.01.0243.
Vancouver Canan F, Aydinoglu U, Sinani G. Fluoksetine bağlı, geçici normoprolaktinemik galaktore. J Clin Exp Invest. 2013;4(1).

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