BibTex RIS Kaynak Göster

Transient normoprolactinemic galactorrhea induced by fluoxetine

Yıl 2013, , - , 01.03.2013
https://doi.org/10.5799/ahinjs.01.2013.01.0243

Öz

Hormonal side effects of antidepressants are infrequent. Galactorrhea is rarely reported among antidepressant related side effects. Antidepressants can directly stimu­late postsynaptic 5- Hydroxytryptamine (5-HT) receptors in the hypothalamus or indirectly inhibit the tuberoinfun­dibular dopaminergic neurons through 5-HT, which may increase prolactin levels and later cause galactorrhea. However, galactorrhea may develop despite normal pro­lactin levels during antidepressant treatment. We present a case of normoprolactinemic galactorrhea in a woman, related with fluoxetine treatment. This report highlights the presence of unidentified mechanisms of selective serotonin reuptake inhibitor induced galactorrhea. J Clin Exp Invest 2013; 4 (1): 105-106

Kaynakça

  • Bostwick JR, Guthrie SK, Ellingrod VL. Antipsychot- ic-induced hyperprolactinemia. Pharmacotherapy 2009;29 :64-73.
  • Anand VS. Clomipramine-induced galactorrhea and amenorrhea. Br J Psychiatry 1985;147:87-88.
  • Gülsün M, Evrensel A, Verim S. Galactorrhea during escitalopram treatment: A case report Bulletin of Clical Psychopharmacology 2006;16:39-41.
  • Nicholas L, Dawkins K, Golden RN. Psychoneuroen- docrinology of depression. Prolactin. Psychiatr Clin North Am 1998;21:341-358.
  • Arya DK. Extrapyramidal symptoms with selec- tive serotonin reuptake inhibitors. Br J Psychiatry 1994;165:728-733.
  • Gulsun M, Algul A, Semiz UB, et al. A case with eupro- lactinemic galactorrhea induced by escitalopram. Int J Psychiatry Med 2007;37:275-278.
  • Belli H, Vardar MK, Yesilyurt S, et al. Citalopram related euprolactinaemic galactorrhoea: a case report. West Indian Med J 2010;59:100-101.
  • Peterson MC. Reversible galactorrhea and prolactin elevation related to fluoxetine use. Mayo Clin Proc 2001;76:215-216.
  • Meltzer H, Bastani B, Jayathilake K, Maes M. Fluox- etine, but not tricyclic antidepressants, potentiates the 5-hydroxytryptophan-mediated increase in plasma cortisol and prolactin secretion in subjects with ma- jor depression or with obsessive-compulsive disorder. Neuropsychopharmacology 1997;17:1-11.
  • Haefliger T, Bonsack C. Atypical antipsychotics and sexual dysfunction: five case-reports associated with risperidone. Encephale 2006;32:97-105.

Fluoksetine bağlı, geçici normoprolaktinemik galaktore

Yıl 2013, , - , 01.03.2013
https://doi.org/10.5799/ahinjs.01.2013.01.0243

Öz

Antidepresanlara bağlı hormonal yan etkiler sık görülme­mektedir. Galaktore, antidepresanlara bağlı yan etkiler arasında nadiren bildirilmiştir. Antidepresanlar, hipotala­mustaki postsinaptik 5-Hidroksitriptamin (5-HT) reseptör­lerini doğrudan uyararak veya tuberoinfindibuler dopami­nerjik nöronları 5-HT üzerinden dolaylı olarak inhibe ede­rek prolaktin seviyelerinde artışa ve sonuçta galaktoreye neden olabilirler. Ancak antidepresan tedavisi sırasında normal prolaktin seviyelerine rağmen galaktore gelişebilir. Bu çalışmada fluoksetin tedavisi ile ilişkili normoprolakti­nemik galaktore gelişen bir kadın olgu sunulacaktır. Bu olgu sunumu ile selektif serotonin gerialım inhibitörlerine bağlı galaktorenin tanımlanmamış mekanizmalarının var­lığı üzerine vurgu yapılacaktır.

Kaynakça

  • Bostwick JR, Guthrie SK, Ellingrod VL. Antipsychot- ic-induced hyperprolactinemia. Pharmacotherapy 2009;29 :64-73.
  • Anand VS. Clomipramine-induced galactorrhea and amenorrhea. Br J Psychiatry 1985;147:87-88.
  • Gülsün M, Evrensel A, Verim S. Galactorrhea during escitalopram treatment: A case report Bulletin of Clical Psychopharmacology 2006;16:39-41.
  • Nicholas L, Dawkins K, Golden RN. Psychoneuroen- docrinology of depression. Prolactin. Psychiatr Clin North Am 1998;21:341-358.
  • Arya DK. Extrapyramidal symptoms with selec- tive serotonin reuptake inhibitors. Br J Psychiatry 1994;165:728-733.
  • Gulsun M, Algul A, Semiz UB, et al. A case with eupro- lactinemic galactorrhea induced by escitalopram. Int J Psychiatry Med 2007;37:275-278.
  • Belli H, Vardar MK, Yesilyurt S, et al. Citalopram related euprolactinaemic galactorrhoea: a case report. West Indian Med J 2010;59:100-101.
  • Peterson MC. Reversible galactorrhea and prolactin elevation related to fluoxetine use. Mayo Clin Proc 2001;76:215-216.
  • Meltzer H, Bastani B, Jayathilake K, Maes M. Fluox- etine, but not tricyclic antidepressants, potentiates the 5-hydroxytryptophan-mediated increase in plasma cortisol and prolactin secretion in subjects with ma- jor depression or with obsessive-compulsive disorder. Neuropsychopharmacology 1997;17:1-11.
  • Haefliger T, Bonsack C. Atypical antipsychotics and sexual dysfunction: five case-reports associated with risperidone. Encephale 2006;32:97-105.
Toplam 10 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Olgu Sunumu
Yazarlar

Fatih Canan Bu kişi benim

Unsal Aydinoglu Bu kişi benim

Gjergji Sinani Bu kişi benim

Yayımlanma Tarihi 1 Mart 2013
Yayımlandığı Sayı Yıl 2013

Kaynak Göster

APA Canan, F., Aydinoglu, U., & Sinani, G. (2013). Fluoksetine bağlı, geçici normoprolaktinemik galaktore. Journal of Clinical and Experimental Investigations, 4(1). https://doi.org/10.5799/ahinjs.01.2013.01.0243
AMA Canan F, Aydinoglu U, Sinani G. Fluoksetine bağlı, geçici normoprolaktinemik galaktore. J Clin Exp Invest. Mart 2013;4(1). doi:10.5799/ahinjs.01.2013.01.0243
Chicago Canan, Fatih, Unsal Aydinoglu, ve Gjergji Sinani. “Fluoksetine bağlı, geçici Normoprolaktinemik Galaktore”. Journal of Clinical and Experimental Investigations 4, sy. 1 (Mart 2013). https://doi.org/10.5799/ahinjs.01.2013.01.0243.
EndNote Canan F, Aydinoglu U, Sinani G (01 Mart 2013) Fluoksetine bağlı, geçici normoprolaktinemik galaktore. Journal of Clinical and Experimental Investigations 4 1
IEEE F. Canan, U. Aydinoglu, ve G. Sinani, “Fluoksetine bağlı, geçici normoprolaktinemik galaktore”, J Clin Exp Invest, c. 4, sy. 1, 2013, doi: 10.5799/ahinjs.01.2013.01.0243.
ISNAD Canan, Fatih vd. “Fluoksetine bağlı, geçici Normoprolaktinemik Galaktore”. Journal of Clinical and Experimental Investigations 4/1 (Mart 2013). https://doi.org/10.5799/ahinjs.01.2013.01.0243.
JAMA Canan F, Aydinoglu U, Sinani G. Fluoksetine bağlı, geçici normoprolaktinemik galaktore. J Clin Exp Invest. 2013;4. doi:10.5799/ahinjs.01.2013.01.0243.
MLA Canan, Fatih vd. “Fluoksetine bağlı, geçici Normoprolaktinemik Galaktore”. Journal of Clinical and Experimental Investigations, c. 4, sy. 1, 2013, doi:10.5799/ahinjs.01.2013.01.0243.
Vancouver Canan F, Aydinoglu U, Sinani G. Fluoksetine bağlı, geçici normoprolaktinemik galaktore. J Clin Exp Invest. 2013;4(1).

Cited By

Late-Onset Normoprolactinemic Galactorrhea Associated with Fluoxetine Use: a Case Report
Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology
Aslihan Polat
https://doi.org/10.5455/bcp.20140701043755