Relationship between total antioxidant capacity and the severity of coronary artery disease

Abstract

Objectives: It was known that oxidative/antioxidative balance shifted to oxidative side in patients with coronary artery disease. The aim of this study is to evaluate the relationship between coronary artery disease and total antioxidant status, oxidative stress index. Materials and methods: The study group consisted of 87 consecutive patients who were hospitalized for coronary angiography. Plasma total oxidative status (TOS) and total antioxidative capacity (TAC) levels were measured and oxidative stress index (OSI) was calculated. Results: The TAC values increased statistically significant in the four tertile compared with the first tertile (1.9 ± 0.2 vs 2.0 ± 0.2 mmol Trolox Eq/l) and the TOS values decreased non- significantly in the four tertile ( 5.2 ± 2.8 vs 7.2 ± 5.4 µmol H2O2 Eq/l) as compared to the patients in the first tertile. According to the number of diseased vessels, plasma oxidative characteristics did not differ between the three groups. Conclusions: Plasma TAC levels increased in subjects with coronary atherosclerosis and severity of coronary atherosclerosis is related with TAC.

Keywords

• Coronary artery disease; total antioxidant capacity; oxidative stress

Total antioksidan kapasite ile koroner arter hastalığı şiddeti arasındaki ilişki

Öz

Amaç: Koroner arter hastalarında oksidatif/ antioksidatif dengenin oksidatif taraf lehine kaydığı bilinmektedir. Bu çalışmanın amacı, total antioksidan durum, oksidatif yük ve koroner arter hastalığı arasındaki ilişkiyi incelemektir. Gereç ve yöntem: Çalışma grubu, koroner Anjiyografi yapmak için hastaneye yatırılan ardışık 87 hastadan oluşmaktadır. Plazma total oksidatif durum (TOD) ve total antioksidan kapasite (TAK) seviyeleri ölçüldü ve oksidatif stres indeksi (OSİ) hesaplandı. Bulgular: Dördüncü gruptaki TAK değerleri ilk grup (1.9 ± 0.2 vs 2.0 ± 0.2 mmol Trolox Eq/l) ile karşılaştırıldığında istatistiksel olarak anlamlı derecede artmıştı ve birinci gruptaki hastalar ile karşılaştırıldığında, dördüncü gruptaki ( 5.2 ± 2.8 vs 7.2 ± 5.4 µmol H2O2 Eq/l) TOD değerlerindeki azalma anlamlı değildi. Hastalıklı damar sayısına göre, plazma oksidatif özellikleri üç grup arasında farklı bulunmadı. Sonuç: Plazma TAK düzeyleri koroner arter hastalığı olan kişilerde artmıştır ve koroner aterosklerozun ağırlığı TAK ile ilişkilidir.

Anahtar Kelimeler

• Koroner arter hastalığı, total antioksidan kapasite, oksidatif yük

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