Relationship between total antioxidant capacity and the severity of coronary artery disease

Yıl 2012, , 22 - 28, 01.03.2012

Murat Aydın Yusuf Selcoki Yunus Nazlı Kadir Serkan Yalçın Metin Canbal Bora Demirçelik Ramazan Yiğitoğlu Beyhan Eryonucu

https://doi.org/10.5799/ahinjs.01.2012.01.0105

Cited By: 2

Öz

Objectives: It was known that oxidative/antioxidative balance shifted to oxidative side in patients with coronary artery disease. The aim of this study is to evaluate the relationship between coronary artery disease and total antioxidant status, oxidative stress index. Materials and methods: The study group consisted of 87 consecutive patients who were hospitalized for coronary angiography. Plasma total oxidative status (TOS) and total antioxidative capacity (TAC) levels were measured and oxidative stress index (OSI) was calculated. Results: The TAC values increased statistically significant in the four tertile compared with the first tertile (1.9 ± 0.2 vs 2.0 ± 0.2 mmol Trolox Eq/l) and the TOS values decreased non- significantly in the four tertile ( 5.2 ± 2.8 vs 7.2 ± 5.4 µmol H2O2 Eq/l) as compared to the patients in the first tertile. According to the number of diseased vessels, plasma oxidative characteristics did not differ between the three groups. Conclusions: Plasma TAC levels increased in subjects with coronary atherosclerosis and severity of coronary atherosclerosis is related with TAC.

Anahtar Kelimeler

Coronary artery disease; total antioxidant capacity; oxidative stress

Total antioksidan kapasite ile koroner arter hastalığı şiddeti arasındaki ilişki

Öz

Amaç: Koroner arter hastalarında oksidatif/ antioksidatif dengenin oksidatif taraf lehine kaydığı bilinmektedir. Bu çalışmanın amacı, total antioksidan durum, oksidatif yük ve koroner arter hastalığı arasındaki ilişkiyi incelemektir. Gereç ve yöntem: Çalışma grubu, koroner Anjiyografi yapmak için hastaneye yatırılan ardışık 87 hastadan oluşmaktadır. Plazma total oksidatif durum (TOD) ve total antioksidan kapasite (TAK) seviyeleri ölçüldü ve oksidatif stres indeksi (OSİ) hesaplandı. Bulgular: Dördüncü gruptaki TAK değerleri ilk grup (1.9 ± 0.2 vs 2.0 ± 0.2 mmol Trolox Eq/l) ile karşılaştırıldığında istatistiksel olarak anlamlı derecede artmıştı ve birinci gruptaki hastalar ile karşılaştırıldığında, dördüncü gruptaki ( 5.2 ± 2.8 vs 7.2 ± 5.4 µmol H2O2 Eq/l) TOD değerlerindeki azalma anlamlı değildi. Hastalıklı damar sayısına göre, plazma oksidatif özellikleri üç grup arasında farklı bulunmadı. Sonuç: Plazma TAK düzeyleri koroner arter hastalığı olan kişilerde artmıştır ve koroner aterosklerozun ağırlığı TAK ile ilişkilidir.

Anahtar Kelimeler

Koroner arter hastalığı, total antioksidan kapasite, oksidatif yük

Kaynakça

• Devasagayam TP, Tilak JC, Boloor KK, Sane KS, Ghas- kadbi SS, Lele RD. Free radicals and antioxidants in human health: current status and future prospects. J Assoc Physicians India 2004; 52(1): 94-9.
• Serdar Z, Aslan K, Dirican M, Sarandöl E, Yesilbursa D, Serdar A. Lipid and protein oxidation and antioxidant status in patients with angiographically proven coro- nary artery disease. Clin Biochem 2006; 39(8):794- 803.
• Bridges BA, Bowyer DE, Hansen ES, Penn A, Waka- bayashi K. The possible involvement of somatic muta- tions in the development of atherosclerotic plaques. Mutat Res 1990;239 (3):143-8.
• Nojiri S. Daida H, Mokuno H, et al. Association of se- rum antioxidant capacity with coronary artery disease in middle-aged men. Jpn Heart J 2001; 42 (6):677-90.
• Schwenke DC. Antioxidants and atherogenesis. J Nutr Biochem 1998;9: 424-45.
• Yeum KJ, Russell RM, Krinsky NI, Aldini G. Biomarkers of antioxidant capacity in the hydrophilic and lipophilic compartments of human plasma. Arch Biochem Bio- phys 2004;430 (1):97-103.
• Erel O. A novel automated method to measure total antioxidant response against potent free radical reac- tions. Clin Biochem 2004;37(2):112-9.
• Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem 2005;38(12):1103-11.
• Gur M, Aslan M, Yildiz A, et al. Paraoxonase and ar- ylesterase activities in coronary artery disease. Eur J Clin Invest 2006; 36(11):779-87.
• Demirbag R, Yilmaz R, Kocyigit A. Relationship be- tween DNA damage, total antioxidant capacity and coronary artery disease. Mutat Res 2005; 570(2):197- 203.
• Austen WG, Edwards JE, Frye RL, et al. A reporting system on patients evaluated for coronary artery dis- ease. Report of the Ad Hoc Committee for Grading of Coronary Artery Disease, Council on Cardiovascu- lar Surgery, American Heart Association. Circulation 1975;51(4 Suppl):5-40.
• Gensini GG. A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol 1983;51(3):606-7.
• Demirbag R, Gur M, Yilmaz R, Kunt AS, Erel O, Andac MH. Influence of oxidative stress on the development of collateral circulation in total coronary occlusions. Int J Cardiol 2007;116(1):14-9.
• Young IS, Woodside JV. Antioxidants in health and disease. J Clin Pathol 2001;54(3): 176-86.
• Lopes HF, Martin KL, Nashar K, Morrow JD, Good- friend TL, Egan BM. DASH diet lowers blood pressure and lipid-induced oxidative stress in obesity. Hyper- tension 2003;41(3):422-30.
• Casalone R, Granata P, Minelli E, et al. Cytogen- ic analysis reveals clonal proliferation of smooth muscle cells in atherosclerotic plaques. Hum Genet 1991;87(2):139-43.
• Nia AB, van schooten FJ, Schilderman PAEL, et al. A multi-biomarker approach to study the effects of smoking on oxidative DNA damage and repair and antioxidative defense mechanisms. Carcinogenesis 2001;22(3):395-401.
• Fuhrman B, Rosenblat M, Hayek T, Coleman R, Avi- ram M. Ginger extract consumption reduces plasma cholesterol, inhibits LDL oxidation and attenuates de- velopment of atherosclerosis in atherosclerotic, apoli- poprotein E-deficient mice. J Nutr 2000;130(5):1124- 31.
• Regnström J, Nilsson J, Tornvall P, Landou C, Ham- sten A. Susceptibility to low density lipoprotein oxi- dation and coronary atherosclerosis in man. Lancet 1992;339(8803):1183-6.
• Croft KD, Dimmitt SB, Moulton C, Beilin LJ. Low den- sity lipoprotein composition and oxidizability in coro- nary disease-apparent favourable effect of beta block- ers. Atherosclerosis 1992;97(2-3):123-30.
• Orem C, Orem A, Uydu HA, Celik S, Erdol C, Kural BV. The effects of lipid-lowering therapy on low-den- sity lipoprotein autoantibodies: relationship with low- density lipoprotein oxidation and plasma total antioxi- dant status. Coron Artery Dis. 2002:13(1):65-71.
• Wayner DD, Burton GW, Ingold KU, Barclay LR, Locke SJ. The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human blood plasma. Biochim Biophys Acta 1987;924(3):408-19.
• Demirbag R, Yilmaz R, Kunt AS, Gur M, Ulucay A, Unlu D. Relation between plasma total anti-oxidant capacity and thoracic aortic intima-media thickness. Echocardiography 2006;23(3):183-88.
• Gokce N, Frei B. Basic research in antioxidant inhi- bition of steps in atherogenesis. J Cardiovasc Risk 1996;3(4):352-7.
• Jialal I, Grundy SM. Effect of combinated supple- mentation wit α-tocopherol, ascorbate, and β caro- tene on low-density lipoprotein oxidation. Circulation 1993;88(6):2780-6.
• Alessio HM, Hagerman AE, Fulkerson BK, Ambrose J, Rice RE, Wiley RL. Generation of reactive oxygen species after exhaustive aerobic and isometric exer- cise. Med Sci Sports Exerc 2000;32(9):1576-81.