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Beta-human chorionic gonadotropin concentrations in cervicovaginal secretions as an early marker of preterm delivery

Year 2010, Volume: 1 Issue: 1, 16 - 20, 01.03.2010
https://doi.org/10.5799/ahinjs.01.2010.01.0004

Abstract

Objectives: To investigate beta-human corionic gonadotropin (β-hCG) levels in cervicovaginal secretions as an early marker for preterm delivery. Methods: The study included 55 patients at 25-36 of gestational weeks with preterm delivery risk factors including a history of preterm labor in a previous pregnancy or history of second trimester abortion. Beta-human chorionic gonadotropin (β-hCG) levels of cervicovaginal secretions were measured in all patients by the radioimmunoassay method using a commercial kit. Results: Preterm delivery was observed in 25 patients and 30 patients gave term delivery. No significant differences were found between preterm and term delivery groups in age, gravidity and parity (P>0.05). APGAR scores and anthropometric measurements of newborns were significantly lower in preterm delivery group (P

References

  • Copper RL, Goldenberg RL, Creasy RK, et al. A multicenter study of preterm birth weight and gestational age-specific neonatal mortality. Am J Obstet Gynecol 1993;168:78-84.
  • McLean M, Bistis A, Davis J, et al. Prediction risk of preterm delivery by second-trimester measurement of maternal plas- ma corticotropin-releasing hormone and alpha-fetoprotein concentrations. Am J Obstet Gynecol 1999;181:207-15.
  • Pateroster DM, Stella A, Gerace P, Manganelli F, Plebani M, Snijders D. Biochemical markers for the prediction of spontaneous preterm birth. Int J Gynecol Obstet 2002;79 2:123-9.
  • Leitich H, Egarter C, Kaider A, Hohlagschwandtner M, Berg- hammer P, Husslein P. Cervicovaginal fetal fibronectin as a marker for preterm delivery: a meta-analysis. Am J Obstet Gynecol 1991 ;165:858-66.
  • Iams JD, Casal D, McGregor JA, et al. Fetal fibronectin im- proves the accuracy of diagnosis of preterm labor. Am J Obstet Gynecol 1995;173:141-5.
  • Brecht G, Creasy RK. Preterm Labor: its diagnosis and man- agement. Am J Obstet Gynecol 1986;3:154-9.
  • Gqzaway CP. Mullinsi L. Prevention of preterm labor and premature rupture of the membranes. Clin Obstet Gynecol 1986;29:835-41.
  • Crowley P. Prophylactic corticosteroids for preterm birth. Co- chrance Database Syst Rev 2000;2:, p. CD000065.
  • Kletzky OA, Rossman F, Bertolli SI, Platt LD, Mishell DR. Dynamics of human chorionic gonadotropin, prolactin, and growth hormone in serum and amniotic fluid through- out normal human pregnancy. Am J Obstet Gynecol 1985; 151:878-84.
  • Anai T, Tanaka Y, Hirota Y, Miyakawa I. Vaginal fluid hCG levels for detecting premature rupture of membranes. Ob- stet Gynecol 1997;2:261-4.
  • Bernstein PS, Stern R, Line N, et al. Beta-human chorionic gonadotropin in cervicovaginal secretion as a predictor of preterm delivery. Am J Obstet Gynecol 1998;179:870-3.
  • Guvenal T, Kantas E, Erselcan T, Culhaoglu Y, Çetin A. Beta-human chorionic gonadotropin and prolactin assays in cervicovaginal secretions as a predictor of preterm delivery. Int J Gynecol Obstet 2001;75:229-34.
  • Creasy RK, Gummer BA, Liggins GC. System for pre- dicting spontaneous preterm birth. Obstet Gynecol 1980; 55:693-9.
  • Garshasbi A, Ghazanfari T, Faghih Zadeh S. Beta-human chorionic gonadotropin in cervicovaginal secretions and preterm delivery. Int J Gynecol Obstet 2004,86:358-64.
  • Crowley P. Prophylactic corticosteroids for preterm birth. CochraneDatabase Syst Rev 2000;2:, p. CD000065.
  • Christopher A. Sullivan C, Morrison JC. Emergent manage- ment of the patient in preterm labor. Obstet Gynecol Clin N Am 1995;22:197-202.

Preterm doğumun erken bir belirteci olarak serviko-vajinal sekresyonlardaki gonadotropin konsantrasyonları

Year 2010, Volume: 1 Issue: 1, 16 - 20, 01.03.2010
https://doi.org/10.5799/ahinjs.01.2010.01.0004

Abstract

Amaç: Preterm doğum erken belirteci olarak serviko-vajinal sekresyonlardaki koriyonik gonadotropin\'in rolünü araştırmak. Yöntemler: Bir önceki doğumu erken doğum veya ikinci trimester düşük öyküsü risk faktörü olan, 25-36 gebelik haftasına sahip 55 gebe çalışmaya alındı. Hastaların tümünde servikovajinal sekresyonlardaki beta-insan koriyonik gonadotropin (β-hCG) düzeyleri radioimmunassay yöntemiyle ticari bir kit kullanılarak ölçüldü. Bulgular: Gebelerden 25\'i preterm, 30\'u term doğum yaptı. Term ve preterm doğum yapana gebe grupları arasında yaş, gebelik sayısı ve parite açısından farklılık saptanmadı (P>0.05). Preterm doğum grubunda yenidoğan APGAR skorları ve bebeklerin antropometrik ölçümleri term doğum grubundan anlamlı düşük bulundu (P

References

  • Copper RL, Goldenberg RL, Creasy RK, et al. A multicenter study of preterm birth weight and gestational age-specific neonatal mortality. Am J Obstet Gynecol 1993;168:78-84.
  • McLean M, Bistis A, Davis J, et al. Prediction risk of preterm delivery by second-trimester measurement of maternal plas- ma corticotropin-releasing hormone and alpha-fetoprotein concentrations. Am J Obstet Gynecol 1999;181:207-15.
  • Pateroster DM, Stella A, Gerace P, Manganelli F, Plebani M, Snijders D. Biochemical markers for the prediction of spontaneous preterm birth. Int J Gynecol Obstet 2002;79 2:123-9.
  • Leitich H, Egarter C, Kaider A, Hohlagschwandtner M, Berg- hammer P, Husslein P. Cervicovaginal fetal fibronectin as a marker for preterm delivery: a meta-analysis. Am J Obstet Gynecol 1991 ;165:858-66.
  • Iams JD, Casal D, McGregor JA, et al. Fetal fibronectin im- proves the accuracy of diagnosis of preterm labor. Am J Obstet Gynecol 1995;173:141-5.
  • Brecht G, Creasy RK. Preterm Labor: its diagnosis and man- agement. Am J Obstet Gynecol 1986;3:154-9.
  • Gqzaway CP. Mullinsi L. Prevention of preterm labor and premature rupture of the membranes. Clin Obstet Gynecol 1986;29:835-41.
  • Crowley P. Prophylactic corticosteroids for preterm birth. Co- chrance Database Syst Rev 2000;2:, p. CD000065.
  • Kletzky OA, Rossman F, Bertolli SI, Platt LD, Mishell DR. Dynamics of human chorionic gonadotropin, prolactin, and growth hormone in serum and amniotic fluid through- out normal human pregnancy. Am J Obstet Gynecol 1985; 151:878-84.
  • Anai T, Tanaka Y, Hirota Y, Miyakawa I. Vaginal fluid hCG levels for detecting premature rupture of membranes. Ob- stet Gynecol 1997;2:261-4.
  • Bernstein PS, Stern R, Line N, et al. Beta-human chorionic gonadotropin in cervicovaginal secretion as a predictor of preterm delivery. Am J Obstet Gynecol 1998;179:870-3.
  • Guvenal T, Kantas E, Erselcan T, Culhaoglu Y, Çetin A. Beta-human chorionic gonadotropin and prolactin assays in cervicovaginal secretions as a predictor of preterm delivery. Int J Gynecol Obstet 2001;75:229-34.
  • Creasy RK, Gummer BA, Liggins GC. System for pre- dicting spontaneous preterm birth. Obstet Gynecol 1980; 55:693-9.
  • Garshasbi A, Ghazanfari T, Faghih Zadeh S. Beta-human chorionic gonadotropin in cervicovaginal secretions and preterm delivery. Int J Gynecol Obstet 2004,86:358-64.
  • Crowley P. Prophylactic corticosteroids for preterm birth. CochraneDatabase Syst Rev 2000;2:, p. CD000065.
  • Christopher A. Sullivan C, Morrison JC. Emergent manage- ment of the patient in preterm labor. Obstet Gynecol Clin N Am 1995;22:197-202.
There are 16 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

M. Erdal Sak This is me

Sibel Sak This is me

Talip Gül This is me

Publication Date March 1, 2010
Published in Issue Year 2010 Volume: 1 Issue: 1

Cite

APA Sak, M. E., Sak, S., & Gül, T. (2010). Preterm doğumun erken bir belirteci olarak serviko-vajinal sekresyonlardaki gonadotropin konsantrasyonları. Journal of Clinical and Experimental Investigations, 1(1), 16-20. https://doi.org/10.5799/ahinjs.01.2010.01.0004
AMA Sak ME, Sak S, Gül T. Preterm doğumun erken bir belirteci olarak serviko-vajinal sekresyonlardaki gonadotropin konsantrasyonları. J Clin Exp Invest. March 2010;1(1):16-20. doi:10.5799/ahinjs.01.2010.01.0004
Chicago Sak, M. Erdal, Sibel Sak, and Talip Gül. “Preterm doğumun Erken Bir Belirteci Olarak Serviko-Vajinal Sekresyonlardaki Gonadotropin Konsantrasyonları”. Journal of Clinical and Experimental Investigations 1, no. 1 (March 2010): 16-20. https://doi.org/10.5799/ahinjs.01.2010.01.0004.
EndNote Sak ME, Sak S, Gül T (March 1, 2010) Preterm doğumun erken bir belirteci olarak serviko-vajinal sekresyonlardaki gonadotropin konsantrasyonları. Journal of Clinical and Experimental Investigations 1 1 16–20.
IEEE M. E. Sak, S. Sak, and T. Gül, “Preterm doğumun erken bir belirteci olarak serviko-vajinal sekresyonlardaki gonadotropin konsantrasyonları”, J Clin Exp Invest, vol. 1, no. 1, pp. 16–20, 2010, doi: 10.5799/ahinjs.01.2010.01.0004.
ISNAD Sak, M. Erdal et al. “Preterm doğumun Erken Bir Belirteci Olarak Serviko-Vajinal Sekresyonlardaki Gonadotropin Konsantrasyonları”. Journal of Clinical and Experimental Investigations 1/1 (March 2010), 16-20. https://doi.org/10.5799/ahinjs.01.2010.01.0004.
JAMA Sak ME, Sak S, Gül T. Preterm doğumun erken bir belirteci olarak serviko-vajinal sekresyonlardaki gonadotropin konsantrasyonları. J Clin Exp Invest. 2010;1:16–20.
MLA Sak, M. Erdal et al. “Preterm doğumun Erken Bir Belirteci Olarak Serviko-Vajinal Sekresyonlardaki Gonadotropin Konsantrasyonları”. Journal of Clinical and Experimental Investigations, vol. 1, no. 1, 2010, pp. 16-20, doi:10.5799/ahinjs.01.2010.01.0004.
Vancouver Sak ME, Sak S, Gül T. Preterm doğumun erken bir belirteci olarak serviko-vajinal sekresyonlardaki gonadotropin konsantrasyonları. J Clin Exp Invest. 2010;1(1):16-20.