Beta-human chorionic gonadotropin concentrations in cervicovaginal secretions as an early marker of preterm delivery

Yıl 2010, Cilt: 1 Sayı: 1, 16 - 20, 01.03.2010

M. Erdal Sak Sibel Sak Talip Gül

https://doi.org/10.5799/ahinjs.01.2010.01.0004

Cited By: 1

Öz

Objectives: To investigate beta-human corionic gonadotropin (β-hCG) levels in cervicovaginal secretions as an early marker for preterm delivery. Methods: The study included 55 patients at 25-36 of gestational weeks with preterm delivery risk factors including a history of preterm labor in a previous pregnancy or history of second trimester abortion. Beta-human chorionic gonadotropin (β-hCG) levels of cervicovaginal secretions were measured in all patients by the radioimmunoassay method using a commercial kit. Results: Preterm delivery was observed in 25 patients and 30 patients gave term delivery. No significant differences were found between preterm and term delivery groups in age, gravidity and parity (P>0.05). APGAR scores and anthropometric measurements of newborns were significantly lower in preterm delivery group (P

Anahtar Kelimeler

Preterm delivery, beta-hCG, predictive value, servico-vaginal secretions

Preterm doğumun erken bir belirteci olarak serviko-vajinal sekresyonlardaki gonadotropin konsantrasyonları

Öz

Amaç: Preterm doğum erken belirteci olarak serviko-vajinal sekresyonlardaki koriyonik gonadotropin\'in rolünü araştırmak. Yöntemler: Bir önceki doğumu erken doğum veya ikinci trimester düşük öyküsü risk faktörü olan, 25-36 gebelik haftasına sahip 55 gebe çalışmaya alındı. Hastaların tümünde servikovajinal sekresyonlardaki beta-insan koriyonik gonadotropin (β-hCG) düzeyleri radioimmunassay yöntemiyle ticari bir kit kullanılarak ölçüldü. Bulgular: Gebelerden 25\'i preterm, 30\'u term doğum yaptı. Term ve preterm doğum yapana gebe grupları arasında yaş, gebelik sayısı ve parite açısından farklılık saptanmadı (P>0.05). Preterm doğum grubunda yenidoğan APGAR skorları ve bebeklerin antropometrik ölçümleri term doğum grubundan anlamlı düşük bulundu (P

Anahtar Kelimeler

Preterm doğum, beta-hCG, prediktif değer, serviko-vajinal sekresyonlar

Kaynakça

• Copper RL, Goldenberg RL, Creasy RK, et al. A multicenter study of preterm birth weight and gestational age-specific neonatal mortality. Am J Obstet Gynecol 1993;168:78-84.
• McLean M, Bistis A, Davis J, et al. Prediction risk of preterm delivery by second-trimester measurement of maternal plas- ma corticotropin-releasing hormone and alpha-fetoprotein concentrations. Am J Obstet Gynecol 1999;181:207-15.
• Pateroster DM, Stella A, Gerace P, Manganelli F, Plebani M, Snijders D. Biochemical markers for the prediction of spontaneous preterm birth. Int J Gynecol Obstet 2002;79 2:123-9.
• Leitich H, Egarter C, Kaider A, Hohlagschwandtner M, Berg- hammer P, Husslein P. Cervicovaginal fetal fibronectin as a marker for preterm delivery: a meta-analysis. Am J Obstet Gynecol 1991 ;165:858-66.
• Iams JD, Casal D, McGregor JA, et al. Fetal fibronectin im- proves the accuracy of diagnosis of preterm labor. Am J Obstet Gynecol 1995;173:141-5.
• Brecht G, Creasy RK. Preterm Labor: its diagnosis and man- agement. Am J Obstet Gynecol 1986;3:154-9.
• Gqzaway CP. Mullinsi L. Prevention of preterm labor and premature rupture of the membranes. Clin Obstet Gynecol 1986;29:835-41.
• Crowley P. Prophylactic corticosteroids for preterm birth. Co- chrance Database Syst Rev 2000;2:, p. CD000065.
• Kletzky OA, Rossman F, Bertolli SI, Platt LD, Mishell DR. Dynamics of human chorionic gonadotropin, prolactin, and growth hormone in serum and amniotic fluid through- out normal human pregnancy. Am J Obstet Gynecol 1985; 151:878-84.
• Anai T, Tanaka Y, Hirota Y, Miyakawa I. Vaginal fluid hCG levels for detecting premature rupture of membranes. Ob- stet Gynecol 1997;2:261-4.
• Bernstein PS, Stern R, Line N, et al. Beta-human chorionic gonadotropin in cervicovaginal secretion as a predictor of preterm delivery. Am J Obstet Gynecol 1998;179:870-3.
• Guvenal T, Kantas E, Erselcan T, Culhaoglu Y, Çetin A. Beta-human chorionic gonadotropin and prolactin assays in cervicovaginal secretions as a predictor of preterm delivery. Int J Gynecol Obstet 2001;75:229-34.
• Creasy RK, Gummer BA, Liggins GC. System for pre- dicting spontaneous preterm birth. Obstet Gynecol 1980; 55:693-9.
• Garshasbi A, Ghazanfari T, Faghih Zadeh S. Beta-human chorionic gonadotropin in cervicovaginal secretions and preterm delivery. Int J Gynecol Obstet 2004,86:358-64.
• Crowley P. Prophylactic corticosteroids for preterm birth. CochraneDatabase Syst Rev 2000;2:, p. CD000065.
• Christopher A. Sullivan C, Morrison JC. Emergent manage- ment of the patient in preterm labor. Obstet Gynecol Clin N Am 1995;22:197-202.