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Variants of systemic mastocytosis: A report of three cases

Year 2015, Volume: 6 Issue: 1, 65 - 68, 10.05.2015
https://doi.org/10.5799/ahinjs.01.2015.01.0488

Abstract

Advanced systemic mast cell neoplasms are very rare tumors and systemic mastocytosis is in the form of atypical leukemic infiltration of neoplastic mast cells to bone marrow and/or other organs. In this study, histological, immunohistochemical, flow cytometry, and molecular genetic findings of three patients that showing the increase in mast cells in the bone marrow discussed in terms of aggressive systemic mastocytosis, mast cell leukemia, systemic mastocytosis with associated clonal hematological non-mast lineage disease and myelomastocytic leukemia differential diagnosis in the light of the scientific literature. J Clin Exp Invest 2015; 6 (1): 65-68 Key words: Mast cell, neoplasm, differential diagnosis

References

  • Arredondo AR, Gotlib J, Shier L, et al. Myelomastocytic
  • leukemia versus mast cell leukemia versus systemic
  • mastocytosis associated with acute myeloid leukemia:
  • a diagnostic challenge. Am J Hematol 2010;85:600-
  • -
  • Valent P, Horny HP, Escribano L, et al. Diagnostic criteria
  • and classification of mastocytosis: a consensus
  • proposal. Leuk Res 2001;25:603-625.
  • Valent P, Akin C, Escribano L, et al. Standards and standardization
  • in mastocytosis: consensus statements
  • on diagnostics, treatment recommendations and response
  • criteria. Eur J Clin Invest 2007;37:435–453.
  • Valent P, Sperr WR, Schwartz LB, et al. Diagnosis and
  • classification of mast cell proliferative disorders: delineation
  • from immunologic diseases and non-mast
  • cell hematopoietic neoplasms. J Allergy Clin Immunol
  • ;114:3-11.
  • Valent P, Akin C, Sperr WR, et al. Diagnosis and treatment
  • of systemic mastocytosis: state of the art. Br J
  • Haematol 2003;122:695-717.
  • Horny H.P, Sotlar K, Valent P, et al. Mastocytosis: state
  • of the art. Pathobiology 2007;74:121-132.
  • Sperr W.R, Horny H.P, Lechner K, et al. Clinical and biologic
  • diversity of leukemias occurring in patients with
  • mastocytosis. Leuk Lymphoma 2000;37:473-486.
  • Noack F, Sotlar K, Notter M, et al. Aleukemic mast cell
  • leukemia with abnormal immunophenotype and c-kit
  • mutation D816V. Leuk Lymphoma 2004;45:2295-
  • -
  • Valent P, Somorapoompichit P, Sperr WR, et al. Myelomastocytic
  • leukemia: myeloid neoplasm characterized
  • by partial differentiation of mast cell-lineage cells.
  • Hematol J 2002;3:90-94.
  • Valent P, Sperr WR, Somorapoompichit P, et al. Myelomastocytic
  • overlap syndromes: biology, criteria, and
  • relationship to mastocytosis. Leuk Res 2001;25:595-
  • -

Sistemik mastositoz: Üç olgu sunumu

Year 2015, Volume: 6 Issue: 1, 65 - 68, 10.05.2015
https://doi.org/10.5799/ahinjs.01.2015.01.0488

Abstract

İleri sistemik mast hücreli neoplaziler oldukça nadir tümörlerdir. Sistemik mastositoz, kemik iliği ve/veya diğer organlara neoplastik mast hücrelerinin atipik lösemik infiltrasyonu biçimindedir. Bu çalışmada kemik iliğinde mast hücre artışı gösteren 3 olgunun histolojik, immünohistokimyasal, flowsitometri ve genetik bulguları, ileri mast hücreli neoplazmlar -agresif sistemik mastositoz, mast hücreli lösemi, mast hücre dışı klonal hematolojik bir hastalıkla beraber olan sistemik mastositoz- ayırıcı tanısı açısından tartışılmıştır

References

  • Arredondo AR, Gotlib J, Shier L, et al. Myelomastocytic
  • leukemia versus mast cell leukemia versus systemic
  • mastocytosis associated with acute myeloid leukemia:
  • a diagnostic challenge. Am J Hematol 2010;85:600-
  • -
  • Valent P, Horny HP, Escribano L, et al. Diagnostic criteria
  • and classification of mastocytosis: a consensus
  • proposal. Leuk Res 2001;25:603-625.
  • Valent P, Akin C, Escribano L, et al. Standards and standardization
  • in mastocytosis: consensus statements
  • on diagnostics, treatment recommendations and response
  • criteria. Eur J Clin Invest 2007;37:435–453.
  • Valent P, Sperr WR, Schwartz LB, et al. Diagnosis and
  • classification of mast cell proliferative disorders: delineation
  • from immunologic diseases and non-mast
  • cell hematopoietic neoplasms. J Allergy Clin Immunol
  • ;114:3-11.
  • Valent P, Akin C, Sperr WR, et al. Diagnosis and treatment
  • of systemic mastocytosis: state of the art. Br J
  • Haematol 2003;122:695-717.
  • Horny H.P, Sotlar K, Valent P, et al. Mastocytosis: state
  • of the art. Pathobiology 2007;74:121-132.
  • Sperr W.R, Horny H.P, Lechner K, et al. Clinical and biologic
  • diversity of leukemias occurring in patients with
  • mastocytosis. Leuk Lymphoma 2000;37:473-486.
  • Noack F, Sotlar K, Notter M, et al. Aleukemic mast cell
  • leukemia with abnormal immunophenotype and c-kit
  • mutation D816V. Leuk Lymphoma 2004;45:2295-
  • -
  • Valent P, Somorapoompichit P, Sperr WR, et al. Myelomastocytic
  • leukemia: myeloid neoplasm characterized
  • by partial differentiation of mast cell-lineage cells.
  • Hematol J 2002;3:90-94.
  • Valent P, Sperr WR, Somorapoompichit P, et al. Myelomastocytic
  • overlap syndromes: biology, criteria, and
  • relationship to mastocytosis. Leuk Res 2001;25:595-
  • -
There are 37 citations in total.

Details

Primary Language English
Journal Section Case Report
Authors

İbrahim Sarı This is me

A. Yasir Bahar This is me

Mustafa Pehlivan This is me

Publication Date May 10, 2015
Published in Issue Year 2015 Volume: 6 Issue: 1

Cite

APA Sarı, İ., Bahar, A. Y., & Pehlivan, M. (2015). Variants of systemic mastocytosis: A report of three cases. Journal of Clinical and Experimental Investigations, 6(1), 65-68. https://doi.org/10.5799/ahinjs.01.2015.01.0488
AMA Sarı İ, Bahar AY, Pehlivan M. Variants of systemic mastocytosis: A report of three cases. J Clin Exp Invest. May 2015;6(1):65-68. doi:10.5799/ahinjs.01.2015.01.0488
Chicago Sarı, İbrahim, A. Yasir Bahar, and Mustafa Pehlivan. “Variants of Systemic Mastocytosis: A Report of Three Cases”. Journal of Clinical and Experimental Investigations 6, no. 1 (May 2015): 65-68. https://doi.org/10.5799/ahinjs.01.2015.01.0488.
EndNote Sarı İ, Bahar AY, Pehlivan M (May 1, 2015) Variants of systemic mastocytosis: A report of three cases. Journal of Clinical and Experimental Investigations 6 1 65–68.
IEEE İ. Sarı, A. Y. Bahar, and M. Pehlivan, “Variants of systemic mastocytosis: A report of three cases”, J Clin Exp Invest, vol. 6, no. 1, pp. 65–68, 2015, doi: 10.5799/ahinjs.01.2015.01.0488.
ISNAD Sarı, İbrahim et al. “Variants of Systemic Mastocytosis: A Report of Three Cases”. Journal of Clinical and Experimental Investigations 6/1 (May 2015), 65-68. https://doi.org/10.5799/ahinjs.01.2015.01.0488.
JAMA Sarı İ, Bahar AY, Pehlivan M. Variants of systemic mastocytosis: A report of three cases. J Clin Exp Invest. 2015;6:65–68.
MLA Sarı, İbrahim et al. “Variants of Systemic Mastocytosis: A Report of Three Cases”. Journal of Clinical and Experimental Investigations, vol. 6, no. 1, 2015, pp. 65-68, doi:10.5799/ahinjs.01.2015.01.0488.
Vancouver Sarı İ, Bahar AY, Pehlivan M. Variants of systemic mastocytosis: A report of three cases. J Clin Exp Invest. 2015;6(1):65-8.