Anafilaksi ve Anafilaksideki Gelişmeler

Year 2011, , 43 - 53, 01.04.2011

İlknur Bostancı Mahmut Doğru

https://doi.org/10.5222/j.child.2011.043

Abstract

Anafilaksi, ani başlayan ve ölüme yol açabilen ciddi siste- mik bir hipersensitivite reaksiyonudur. Anafilaksi klinik bir acildir. Anafilaksi insidansı özellikle yaşamın ilk iki deka- dında artmaktadır. Yaygın olan tetikleyiciler besinler, ilaç- lar ve böcek sokmalarıdır. Tanısı primer olarak klinik kri- terlere dayanır. Bazı hastalarda anafilaksi tanısı kan test- leri artmış histamin ve total triptaz düzeyi gibi ile doğru- lanabilir. Fakat bu testler anafilaksi için spesifik değildir. Adrenalin anafilaksi tedavisinde ilk seçenek ilaçtır. Hastalar taburcu edilirken adrenalin otoenjektörü reçete edilmeli ve kullanımının eğitimi verilmelidir. Bu makalede anafilaksinin patogenezi, kliniği, tanı ve yeni tedavi yön- temleri sunulmuştur

Keywords

Anafilaksi, tanı, tedavi, adrenalin otoenjektör

Anaphylaxis and Advances in Anaphylaxis

Abstract

Anaphylaxis is a serious hypersensitivity reaction with a rapid onset which might eventually lead to death. Anaphylaxis is a clinical emergency. The incidence anaph- ylaxis is increasing, particularly during the first 2 decades of life. Common triggers include foods, medications, and insect stings. Its diagnosis is based primarily on clinical criteria. In some patients the clinical diagnosis of anaph- ylaxis can be confirmed by means of a blood test i.e., an increased plasma histamine or serum total tryptase level . However, these tests are not specific for anaphylaxis. Adrenaline is the first choice medication in the treatment of anaphylaxis. On discharge from hospital, an autoinjectible epinephrine should be prescribed and appropriate should be providd about its use In this review pathogenesis, clini- cal features, diagnosis and new treatment modalities of anaphylaxis were presented

Keywords

Anaphylaxis, diagnosis, treatment, adrenaline autoinjector

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