Risk Factors Associated with Severe Disease in COVID-19

Abstract

Aim: The aim of this study was to determine the characteristics and risk factors associated with severe disease in COVID-19. Materials and Methods: A total of 186 adult patients (97 female) hospitalized with a diagnosis of COVID-19 (laboratory-confirmed cases, SARS-CoV-2-RNA detected with the molecular method) between March 2020-May 2020 were included in the study. The possible risk factors evaluated were age, gender, comorbidities, smoking, symptoms, and laboratory parameters at the time of admission to the hospital. Results: The patients comprised 97 (52.2%) females, evaluated as severe COVID-19 in 43 (23.1%) cases and non-severe COVID-19 in 143 (76.9%) cases. Multivariate logistic regression analysis identified risk factors for severe COVID-19 to be age >65 years (odds ratio (OR)=5.289, 95% confidence interval (CI):1.680-16.651, p:0.004), and elevated levels of LDH (OR=8.521, 95% CI:2.445-29.702, p:0.001), ferritin (OR=7.436, 95% CI:2.171-25.468, p:0.001), D-dimer (OR=10.076, 95% CI: 2.758-36.813, p<0.001), CK-MB (OR=5.916, 95% CI:1.833-19.089, p:0.003), and troponin (OR=9.201, 95% CI:11.886-44.888, p:0.006). Conclusion: The results of this study examining possible risk factors for severe COVID-19 demonstrated that age>65 years, and elevated LDH, ferritin, D-dimer, CK-MB, and troponin levels are independent risk factors. Clinicians should consider these potential risk factors for progression to severe disease when treating COVID-19 patients.

Keywords

• COVID-19
• pandemic
• risk factor
• severe disease

Project Number

Yok

COVID-19'da Ciddi Hastalıkla İlişkili Risk Faktörleri

Abstract

Amaç: Çalışmamızın amacı COVID-19’da şiddetli hastalık ile ilişkili özellikler ve risk faktörlerinin belirlenmesidir. Gereç ve Yöntem: Mart 2020-Mayıs 2020 tarihleri arasında COVID-19 (moleküler yöntemle SARS-CoV-2-RNA tespit edilen olgular) tanısı ile hastaneye yatırılan toplam 186 yetişkin hasta (97 kadın) çalışmaya dahil edildi. Olası risk faktörleri olarak yaş, cinsiyet, komorbidite, sigara kullanımı, semptomlar ve yatış sırasındaki bazı laboratuvar parametreleri irdelendi. Bulgular: Hastaların 97’si (%52,2) kadın olup, 43 (%23,1) olgu şiddetli COVID-19 ve 143 (%76,9) olgu şiddetli olmayan COVID-19 olarak değerlendirildi. Çoklu değişkenli lojistik regresyon analizinde; 65 yaş üzeri (odds oranı (OR)=5.289, %95 güven aralığı (CI) 1.680-16.651, p=0.004), artmış LDH (OR=8.521, 95% CI:2.445-29.702, p:0.001), ferritin (OR=7.436, 95% CI:2.171-25.468, p:0.001), D-dimer (OR=10.076, 95% CI: 2.758-36.813, p<0.001), CK-MB (OR=5.916, 95% CI:1.833-19.089, p:0.003) ve troponin seviyesi (OR=9.201, 95% CI:11.886-44.888, p:0.006) şiddetli COVID-19 için risk faktörleri olarak tanımlandı. Sonuç: Ciddi COVID-19 için olası risk faktörlerini incelediğimiz bu çalışmada 65 yaş üstü, yükselmiş LDH, ferritin, D-dimer, CK-MB ve troponin düzeylerinin bağımsız risk faktörleri olduğunu bulduk. Klinisyenler, COVID-19 hastalarının tedavisi sırasında ciddi hastalığa ilerleme için bu potansiyel risk faktörlerini dikkate almalıdır.

Keywords

• COVID-19
• pandemi
• risk faktörü
• şiddetli hastalık

Supporting Institution

Yok

Project Number

Yok

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