Karbon Monoksit Zehirlenme Şiddeti ile Kan Parametrelerinin İlişkisi

Abstract

Giriş: Karbon monoksit (CO) zehirlenmesi dünya çapında en yaygın zehirlenmelerden biridir. CO zehirlenmesi ile zehirlenme şiddetini tahmin edecek parametreleri araştırmak için birçok çalışma bulunmaktadır. Bu çalışmada kan parametre değerleri ile kanda ölçülen CO değerleri ve zehirlenmenin sonlanımı arasındaki ilişkiyi araştırmayı amaçladık. Metod: Çalışmamız retrospektif bir çalışmadır. Kan gazında CO düzeyi ≥ %10 olan hastalar çalışmaya dahil edildi. Hastalar hiperbarik oksijen ihtiyacı olanlar ve olmayanlar olarak 2 gruba ayrıldı. Hastaların yaş, cinsiyet gibi demografik verileri ile kan gazlarındaki CO düzeyleri, hemoglobin, lökosit, nötrofil, kan sayımı trombosit sayıları, MPV ve PDW değerleri kaydedildi. Ayrıca kreatinin, troponin, CRP, ALT değerleri de kaydedildi. Bulgular: Çalışmaya 110 hasta dahil edildi Hastaların yaş ortalaması 46,80±18,18 idi. Parametreler incelendiğinde HBO tedavisi gereken hastaların WBC sayımı ortancası 8,73 [7,54-11,83], HBO tedavisi gerektirmeyen hastaların WBC sayısı ortancası 8,01 [6,96-9,72] (p=0,038) idi. Benzer şekilde HBO tedavisi gereken hastaların lenfosit sayısı ortancası 2,73 [1,85-3.36] olarak belirlendi ve bu değer HBO tedavisi gerektirmeyen hastalara göre daha yüksek bulundu (p=0,026). Sonuç: Hiperbarik oksijen tedavisi gerektiren CO zehirlenmesi olgularında WBC ve lenfosit sayıları daha yüksektir. Ancak bu iki değer hiperbarik oksijen tedavisini öngörmede bağımsız risk faktörleri değillerdir.

Keywords

• zehirlenme
• karbonmonoksit
• oksijen
• lenfosit
• lökosit

The Relationship of Blood Parameters with the Severity of Carbon Monoxide Poisoning

Abstract

Introduction: Carbon monoxide (CO) poisoning is one of the most common poisonings worldwide. Many studies have investigated the relationship between predictive parameters and CO poisoning severity. We aimed to investigate the relationship between blood parameter values with poor outcome in CO poisoning, and CO values measured in blood. Methods: This is a retrospective study. Patients who had CO levels ≥ %10 in their blood gas were included in the study. Patients were divided into 2 groups as those who required hyperbaric oxygen and those who do not. Demographic data such as age, gender of the patients, as well as CO levels in the blood gases of the patients, hemoglobin, leukocyte, neutrophil, platelet counts of the blood count, and MPV and PDW values were recorded. Also, creatinine, troponin, CRP, ALT values were recorded as well. Results: The study was conducted with 110 patients. The mean age of the patients was 46.80±18.18 years. When the parameters were examined, the median WBC count of patients with patients who required HBO therapy was 8.73[7.54-11.83], and the median WBC count of patients who did not require HBO therapy was 8.01[6.96-9.72] (p=0.038). The median lymphocyte count of patients who required HBO therapy was determined as 2.73[1.85-3.36], and this value was found to be higher than patients who did not require HBO therapy (p=0.026). Conclusion: WBC and lymphocyte counts are higher in CO poisoning patients who required hyperbaric oxygen therapy. But these two values were not found to be independent risk factors in predicting hyperbaric oxygen therapy.

Keywords

• poisoning
• carbon monoxide
• oxygen
• lymphocyte
• leukocytes

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