COVID-19 Hastalarında Hemoglobin Seviyeleri ve Yoğun Bakım Mortalitesi Arasındaki İlişki

Year 2022, , 660 - 664, 30.09.2022

Kezban Özmen Süner , Havva Kocayigit , Gürkan Demir , Yakup Tomak , Selcuk Yaylacı , Ali Fuat Erdem

https://doi.org/10.16899/jcm.1079769

Cited By: 1

Abstract

Amaç: Bu çalışmanın amacı, hemoglobin seviyelerinin, COVID-19 hastalarında mortaliteyi ön görmede etkili olup olmadığının araştırılmasıdır.
Gereç ve Yöntem: Bu retrospektif çalışmaya yoğun bakımda takip edilen 156 COVID-19 hastası dahil edildi. Demografik özellikleri, klinik verileri ve laboratuar bulguları kaydedildi.
Bulgular: Anemi grubu ve normal hemoglobin değerleri olan grubun başvuru esnasındaki ortalama yaş, cinsiyet oranları, komorbiditeleri, semptomları, ortalama APACHE-2 ve SOFA değerleri arasında anlamlı fark yoktu. Normal hemoglobin değerleri olan grubun ortalama lenfosit ve laktat değerleri istatiksel olarak anlamlı düzeyde yüksek bulundu (p<0,05). Anemi grubunda ise ortalama prokalsitonin ve D-dimer değerleri anlamlı düzeyde yüksek bulundu (p<0,05). COVID-19 hastalığının ağırlığı mekanik ventilasyon ihtiyacı, inotropik ajan ve renal replasman tedavisi ihtiyacı yanı sıra Akut Respiratuar Distres Sendrom (ARDS), akut böbrek yetmezliği (ABY) ve çoklu organ yetmezliği gelişimi ile değerlendirildi. Hasta sonuçları yoğun bakımda kalış süresi ve yoğun bakım mortalitesi olarak belirlendi. COVID-19 hastalığının ağırlığını belirleyen parametreler ve hasta sonuçları açısından anemi grubu ve normal grup arasında anlamlı fark bulunmadı. Ancak başvuru esnasındaki ve yoğun bakımın son günündeki hemoglobin seviyeleri ölen grupta sağkalanlara göre anlamlı olarak düşük tespit edildi (p<0,05).
Sonuç: Bu çalışmada, ölen COVID-19 hastalarında hemoglobin seviyeleri daha düşük bulundu. Bununla birlikte anemi ve mortalite arasında anlamlı bir ilişki saptanmadı. COVID-19 hastalarında hemoglobin seviyelerinin mortaliteye etkisinin değerlendirilmesi için daha ileri çalışmalara ihtiyaç vardır.

Keywords

Hemoglobin, COVID-19, yoğun bakım, mortalite

The Relationship Between Hemoglobin Levels and Intensive Care Mortality in COVID-19 Patients

Abstract

Objective: We aimed to investigate whether hemoglobin levels in COVID-19 patients can serve as a valuable predictor of mortality.
Material and Method: This retrospective study included 156 COVID-19 cases who were admitted to the intensive care unit (ICU), demographic characteristics, clinical data, and laboratory findings were recorded.
Results: There are no significant differences in mean age, gender ratio, comorbidities, symptoms, mean APACHE-2, and SOFA values upon admission observed between the anemic and normal groups. The normal hemoglobin (Hgb) group’s mean lymphocyte and lactate values were statistically high(p<0.05), and mean procalcitonin and D-dimer values were high in the anemic group (p<0.05). The severity of COVID-19 in patients was evaluated by the requirement of mechanical ventilation, inotropic agents, and renal replacement treatments as well as the development of acute respiratory distress syndrome (ARDS), acute renal failure (ARF), and multiple organ failure (MOF). Patient outcomes were lengths of ICU stays and ICU mortality. No significant difference was observed in any of the severity parameters or outcomes between the anemic and normal groups. Hemoglobin levels upon admission and final ICU days for the non-survivors group were significantly low than for the survivors group (p<0.05).
Conclusions: We found decreased hemoglobin levels in non-surviving COVID-19 patients. However, we could not find a relationship between anemia and mortality. Further trials are needed to evaluate the impact of hemoglobin levels on mortality in COVID-19 patients.

Keywords

Hemoglobin, Intensive care, Mortality, COVID-19

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