Predictive Value of Routine Laboratory Parameters in Hospitalized COVID-19 Patients on Severity of Illness

Abstract

Aim: Early prediction of Coronavirus disease 2019 (COVID-19) disease severity is important to reduce mortality. Therefore, we sought to determine the clinical correlation between these baseline routine laboratory parameters and their effects on mortality, by retrospectively investigating the routine laboratory parameters of hospitalized COVID-19 patients on admission day. Materials and methods: This retrospective-observational study population consisted of 415 hospitalized COVID-19 patients. Patients were divided into three groups (mild, moderate, and severe) according to their clinical status on admission day. On admission, fifteen routine biochemical and hematological laboratory parameters of COVID-19 patients were evaluated. Results: Aspartate aminotransferase (AST), alanine transaminase (ALT), lactate dehydrogenase (LDH), ferritin, International Normalized Ratio (INR), and d-dimer levels were higher in non-survivors than in survivors, regardless of the initial disease severity group classification. No statistically significant difference was found between the groups in terms of uric acid, monocyte, and platelet count.s Conclusions: There is a need for an urgent scale for detecting COVID-19 severity. AST, ALT, LDH, ferritin, INR, and d-dimer levels may help predict the disease’s severity in COVID-19.

Keywords

• COVID-19
• biochemical parameters
• disease’s severity

Hastanede Yatan COVID-19 Hastalarında Rutin Laboratuvar Parametrelerinin Hastalığın Şiddeti Üzerindeki Öngörü Değeri

Abstract

Amaç: Koronavirus hastalığı 2019 (COVID-19) hastalık şiddetinin erken tahmini, mortaliteyi azaltmak için önemlidir. Bu nedenle, hastaneye yatırılan COVID-19 hastalarının rutin laboratuvar parametrelerini kabul gününde geriye dönük olarak araştırarak, bu temel rutin laboratuvar parametreleri ile mortalite üzerindeki etkileri arasındaki klinik ilişkiyi belirlemeye çalıştık. Gereç ve yöntem: Bu retrospektif-gözlemsel çalışma popülasyonu, hastaneye yatırılan 415 COVID-19 hastasından oluşmaktadır. Hastalar başvuru günlerindeki klinik durumlarına göre (hafif, orta ve şiddetli) üç gruba ayrıldı. Başvuru sırasında COVID-19 hastalarının on beş rutin biyokimyasal ve hematolojik laboratuvar parametresi değerlendirildi. Bulgular: Aspartat aminotransferaz (AST), alanin transaminaz (ALT), laktat dehidrojenaz (LDH), ferritin, Uluslararası Normalleştirilmiş Oran (INR) ve d-dimer seviyeleri, başlangıçtaki hastalık şiddeti grup sınıflandırmasına bakılmaksızın, hayatta kalanlarda hayatta kalanlardan daha yüksekti. Ürik asit, monosit ve trombosit sayıları açısından gruplar arasında istatistiksel olarak anlamlı fark bulunmadı. Sonuç: COVID-19 şiddetini tespit etmek için acil bir ölçeğe ihtiyaç vardır. AST, ALT, LDH, ferritin, INR ve d-dimer seviyeleri, hastalığın COVID-19'daki şiddetini tahmin etmeye yardımcı olabilir.

Keywords

• COVID-19
• biyokimyasal parametreler
• hastalık şiddeti

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