Clinical Importance of Serum Prolidase and Carbonic Anhydrase III Levels In Patients with Stable Chronic Obstructive Pulmonary Disease

Abstract

Aim: Chronic obstructive pulmonary disease (COPD) is a disease characterized by irreversible airway flow limitation and chronic airway inflammation. We aimed to investigate the clinical importance of serum prolidase enzyme, which is an indicator of collagen degradation, and Carbonic anhydrase (CA) III enzyme, which has an important function in acid-base regulation, in patients with COPD Methods : In this study, 56 stable COPD patients and 32 healthy subjects without smoking history and comorbidities were included. Serum CA III and prolidase enzyme levels were compared between the two groups. Results: The statistical difference was not found between the two groups in terms of prolidase enzyme levels (p=0.831). There was a statistically significant increase in CA III levels in the COPD group (p=0.001). There were moderate positively correlation between CAIII with partial pressure of carbon dioxide in blood (pCO2) and negatively correlation between CA III with partial pressure of oxygen in blood (pO2) in COPD patients (r:0.302, p<0.025; r:-0.314, p:0.02). Conclusions: We think that there is an important clinical relationship between CA III and COPD, and therefore, CA III may be a candidate biomarker in the follow-up of COPD.

Keywords

• COPD
• prolidase
• carbonic anhydrase III
• arterial blood gase

Stabil Kronik Obtrüktif Akciğer Hastalığı Hastalarında Serum Prolidaz ve Karbonik Anhidraz III Düzeylerinin Klinik Önemi

Abstract

GİRİŞ: Kronik obstrüktif akciğer hastalığı (KOAH), geri dönüşümsüz hava yolu akış kısıtlaması ve kronik hava yolu iltihabı ile karakterize bir hastalıktır. Kollajen yıkımının bir göstergesi olan serum prolidaz enzimi ile asit-baz regülasyonunda önemli işlevi olan karbonik anhidraz (CA) III enziminin KOAH'lı hastalarda klinik önemini araştırmayı amaçladık. GEREÇ VE YÖNTEM: Bu çalışmaya 56 stabil KOAH'lı hasta ile sigara öyküsü ve ek hastalığı olmayan 32 sağlıklı olgu dahil edildi. Her iki grup arasında serum CA III ve prolidaz enzim düzeyleri karşılaştırıldı. BULGULAR: Prolidaz enzim düzeyleri açısından iki grup arasında istatistiksel fark bulunmadı (p=0.831). KOAH grubunda CA III düzeylerinde istatistiksel olarak anlamlı bir artış vardı (p=0.001). KOAH hastalarında CA III enzimi düzeyi ile kanda kısmi karbondioksit basıcı (pCO2) arasında orta derecede pozitif, kanda kısmi oksijen basıncı (pO2) arasında ise negatif korelasyon vardı (r:0.302, p<0.025; r:-0.314, p:0.02). SONUÇLAR: CA III ile KOAH arasında önemli bir klinik ilişki olduğunu ve bu nedenle CA III'ün KOAH takibinde aday bir biyobelirteç olabileceğini düşünüyoruz.

Keywords

• KOAH
• serum prolidaz
• karbonik anhidraz III
• arter kan gazı

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