İlk Trimesterde Sistemik İmmün-İnflamasyon İndeksini Kullanarak Gestasyonel Diabetes Mellitus'u Tahmin Etme

Year 2022, , 617 - 620, 30.09.2022

Munire Funda Cevher Akdulum , Erhan Demirdağ , Safarova Sahila , Mehmet Erdem , Ahmet Erdem

https://doi.org/10.16899/jcm.1148179

Abstract

Amaç: Gestasyonel diyabetes mellitus (GDM) inflamatuar bir hastalıktır ve gebelik komplikasyonlarını artırır. GDM'nin erken tanınması, komplikasyonları önlemek için kritik öneme sahiptir. Sistemik İmmün-İnflamasyon İndeksi (SII), inflamatuar yanıtı gösteren bir indeks olup, GDM ile ilişkili olabilir. Bu çalışmanın amacı, GDM ve SII arasındaki ilişkiyi özellikle ilk trimesterdeki SII'nin GDM'yi tahmin edip edemeyeceğini belirlemektir.
Gereç ve Yöntem: Çalışma, Ocak 2021 ile Ocak 2022 tarihleri ​​arasında retrospektif kohort çalışması olarak dizayn edildi. Çalışmaya 100 gebe dahil edildi. Çalışma grubu GDM tanısı almış 50 gebeyi içermektedir. Kontrol grubu ise GDM tanısı almamış kalan 50 gebeden oluşturuldu. Hastaların ilk trimesterde ilk ziyaretlerindeki hemogram değerlerinden SII değerleri hesaplandı.
Bulgular: SII, trombosit sayısı, nötrofil sayısı, fT3, apgar 1. dk ve apgar 5. dk ölçümleri açısından GDM ve kontrol grupları arasında istatistiksel olarak anlamlı fark vardı (p<0,05). GDM'yi öngörmek için SII düzeyi cut-off değeri 607,32 olarak belirlendi.
Sonuç: Çalışmada GDM'li kişilerde SII anlamlı olarak daha yüksek bulundu. Basit bir hemogram tetkiki ile SII hesaplanarak gebeliğin ilk trimesterinde GDM'yi predikte etmek için kullanılabilir. İlk trimesterdeki riskli hastalar diyetlerini düzenleyerek, hamilelik sırasında oluşabilecek diyabet komplikasyonlarını azaltabilirler.

Keywords

Sistemik İmmun-İnflamasyon İndeksi, gestasyonel diyabetes mellitus, Gebelik

Predicting Gestational Diabetes Mellitus Using The Systemic Immune-Inflammation Index in The First Trimester

Abstract

Aims: Gestational diabetes mellitus (GDM) is an inflammatory disorder. GDM raises the risk of pregnancy complications. Early recognition of GDM is critical to prevent complications. Systemic Immune-Inflammation Index (SII) is an index that shows the inflammatory response, we hypothesized that it might be associated to GDM. The purpose of this study was to determine the relationship between GDM and SII, as well as whether SII in the first trimester can predict GDM.
Material and Method: This retrospective cohort study was conducted between January 2021 and January 2022. 100 pregnant women were included in the study. The study group included 50 pregnant women who had been diagnosed with GDM. The control group consisted of the remaining 50 pregnant women who had not been diagnosed with GDM. SII values were calculated from the hemogram values of the patients at the first visit in the first trimester.
Results: There was a statistically significant difference between GDM and control groups in terms of SII, platelet, neutrophil, fT3, apgar 1 min and apgar 5 min measurements (p<0.05). The SII level cut-off value for predicting GDM was determined to be 607.32.
Conclusion: SII was found to be significantly higher in people with GDM in the study. It can be used to predict GDM in the first trimester of pregnancy by calculating SII with a simple hemogram. By regulating their diet, patients in the first trimester can reduce the complications of diabetes that can occur during pregnancy.

Keywords

systemic immune inflamation, gestational diabetes mellitus, pregnancy

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