Menometroraji ile Başvuran Ergen Kızlarda Hemostaz Parametrelerinin Değerlendirilmesi ve Sağlıklı Ergenler ile Karşılaştırılması

Year 2022, , 917 - 922, 30.11.2022

Ayşe Esra Tapci , Serçin Taşar , Bulent Alioglu , Yıldız Dallar Bilge , Nermin Dindar Badem

https://doi.org/10.16899/jcm.1161870

Abstract

Amaç: Bu çalışmada menstrüel kanamasında artış ile başvuran adolesan kızlarda edinsel ve kalıtsal pıhtılaşma varlığının araştırılması ve benzer yaş gruplarından sağlıklı adolesan kızlarla hemostaz testlerinin karşılaştırılması amaçlandı.
Yöntem: Çalışmaya hastanemiz çocuk polikliniğine adet kanaması artışı nedeniyle başvuran, akut veya kronik hastalığı olmayan, son 14 gün içinde herhangi bir ilaç kullanmamış 63 adolesan kadın (15.4±1.5 yıl) dahil edildi. Kontrol grubu olarak, çalışma grubu ile benzer yaş ve cinsiyette olarak 74 sağlıklı ergen (15.5±1.5 yıl) alındı. Çalışmaya dahil edilen her olgu için trombosit sayısı, tüm bazal ve ileri pıhtılaşma testleri, trombosit agregasyonu ve sekresyon testleri çalışıldı.
Bulgular: Bazal ve ileri pıhtılaşma testleri, trombosit agregasyon ve sekresyon testleri incelendiğinde ağır adet kanaması olan çalışma grubu ile sağlıklı kontrol grubu arasında anlamlı fark bulunmadı. Öte yandan ağır adet kanaması olan çalışma grubumuzda 4 (%6.3) hastada hemostaz bozukluğu (2 tip 1 von Willebrand hastalığı olan hasta, bir hasta immün trombositopenik purpuralı ve bir hastada hafif faktör VIII eksikliği) saptandı.
Sonuç: Çalışma ve sağlıklı kontrol grupları arasında hemostaz testleri açısından anlamlı bir fark olmadığı belirtilmelidir. Ancak ağır adet kanaması olan grupta başta von Willebrand hastalığı olmak üzere çeşitli hemostaz bozuklukları saptanabilmektedir

Keywords

anomal uterin kanama, koagülasyon bozuklukları, von Willebrand hastalığı

Evaluation of Hemostasis Parameters in Adolescent Girls Presenting with Menometrorrhagia and Comparison with Healthy Adolescents

Abstract

Objective: This study aims to investigate the presence of acquired and hereditary coagulation in adolescent girls presenting with increased menstrual bleeding.
Method: The study consisted of 63 adolescent female patients (15.4±1.5 years) who applied to the pediatric clinic of our hospital due to increased menstrual bleeding, did not have any acute or chronic disease, did not use any medication in the last 14 days, and were of the same age and gender as the study group. 74 healthy adolescents were taken as the healthy control group (15.5±1.5 years). Platelet count, all basal and advanced coagulation tests, platelet aggregation, and secretion tests were studied for each case included in the study.
Results: When basal and advanced coagulation tests, platelet aggregation, and secretion tests were examined, no significant difference was found between the study and the healthy control group. On the other hand, in our study group with heavy menstrual bleeding, 4 (6.3%) patients were found to have impaired hemostasis (2 patients with type 1 von Willebrand disease, one patient with immune thrombocytopenic purpura, and one patient with mild factor VIII deficiency).
Conclusion: Various hemostasis disorders, especially von Willebrand disease, could be detected in the group with heavy menstrual bleeding.

Keywords

: Abnormal uterine bleeding, coagulation disorders, von Willebrand disease

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