Fibromiyalji Sendromu Tanısında Oksidatif Stres İndeksi ve C Vitamini

Abstract

Amaç: FMS tanısı için spesifik bir laboratuvar belirteci yoktur ve esas olarak klinik muayeneye bağlıdır. Serum C vitamini düzeylerinin ve oksidatif stres indeksinin (OSI) Fibromiyalji Sendromu (FMS) tanısında kullanılıp kullanılamayacağını değerlendirmeyi amaçladık. Gereç ve Yöntem: Kesitsel çalışmamıza 53 kadın hasta ve 35 sağlıklı kadın kontrol dahil edildi. Hastalara VAS, BDI ve FIQ uygulandı. C vitamini seviyeleri HPLC ile ölçüldü. Toplam Antioksidan Kapasitesi (TAC) ve Toplam Oksidan Durumu (TOS) seviyeleri Spektrofotometrik yöntemle belirlendi. Bulgular: FMS hastalarının vitamin C ve TAC düzeyleri kontrollere göre anlamlı olarak düşük iken, hastalarda OSİ anlamlı olarak daha yüksekti (sırasıyla p= 0,004, p= 0,009 ve p= 0,048). Hassas noktalar ile FIQ arasında orta düzeyde pozitif ve anlamlı bir ilişki vardı (r = 0,505; p <0,001). ROC analizi ile Vitamin C ve TAC'nin tanısal performansı sırasıyla AUC = 0,678, p= 0,003 ve AUC = 0,639, p= 0,028 olarak bulundu. Sonuç: FMS hastalarında serum TAC ve vitamin C seviyeleri düşmekte ve OSİ artmaktadır. Bu üç parametrenin FMS tanısı için ek bir araç olarak düşünülebileceği önerilebilir.

Keywords

• Fibromiyalji Sendromu
• TAC
• OSI
• C Vitamini
• Kronik ağrı

Project Number

: 2018/22

Oxidative Stress Index and Vitamin C in The Diagnosis of Fibromyalgia Syndrome

Abstract

Aim: Still there is no any specific laboratory marker for diagnosis of FMS and it mainly depends on clinical examination. So that we aimed to evaluate whether serum Vitamin C levels and oxidative stress index (OSI) can be used in the diagnosis of Fibromyalgia Syndrome (FMS). Material and Method: 53 female patients and 35 healthy female controls were enrolled to our cross-sectional study. VAS, BDI and FIQ were applied to the patients. Vitamin C levels were measured by HPLC. Total Antioxidant Capacity (TAC) and Total Oxidant Status (TOS) levels were determined by Spectrophotometric Assay method. Results: While vitamin C and TAC levels of FMS patients were significantly lower than those of the controls, OSI was significantly higher in patients (p= 0.004, p= 0.009 and p= 0.048, respectively). There was a moderate positive and significant relationship between the tender points and FIQ, (r = 0.505; p <0.001). The diagnostic performance of Vitamin C and TAC with ROC analysis were found: AUC = 0.678, p= 0.003, AUC = 0.639, p= 0.028 respectively. Conclusion: Serum TAC and vitamin C levels decrease and OSI increases in FMS patients. It can be suggested that these three parameters can be considered as an additional tool for diagnosis of FMS.

Keywords

• Fibromyalgia Syndrome
• TAC
• OSI
• Vitamin C
• Chronical pain

Supporting Institution

Tokat Gaziosmanpasa University Research Fund

Project Number

: 2018/22

Thanks

We thanks to all all staff of outpatient and laboratory for their contribution.

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