Does Platelet Distribution Width Correlate with Acute Coronary Syndrome Severity and Coronary Thrombus Burden?

Abstract

Aim: Platelets play a pivotal role in the pathogenesis of acute coronary syndrome (ACS), and platelet distribution width (PDW) shows the activities of platelets in circulation. The purpose of this study was to determine the association of PDW with the ACS severity and angiographic intracoronary thrombus burden and Thrombolysis In Myocardial Infarction (TIMI) flow grade. Materials and Methods: One hundred forty-nine consecutive patients who were diagnosed as having ACS were retrospectively evaluated. Global Registry of Acute Coronary Events (GRACE) scores were calculated from the clinical and laboratory data for ACS severity. TIMI flow grades and thrombus grades of the culprit coronary arteries were calculated for each patient. Patients were grouped into two groups according to their PDW values: high PDW and low PDW. The SPSS 17.0 software was used for statistical analysis. Results: PDW was found to be correlated with GRACE scores (P<0.01). The high PDW group had higher GRACE scores (139 vs. 126, p<0.05). Lower TIMI flow grades (0 and 1) were seen in the high PDW group (39 vs. 33, p<0.05). No association between intracoronary thrombus load and PDW was found in our study (p=0.082). Conclusion: In our study, patients with higher PDW levels were older and had higher GRACE scores and lower TIMI flow grades. PDW levels correlate with the ACS severity and TIMI flow grade.

Keywords

• Platelet distribution width
• TIMI flow
• acute coronary syndrome
• coronary thrombus

Trombosit Dağılım Genişliği Akut Koroner Sendrom Şiddeti ve Koroner Trombüs Yükü ile İlişkili mi?

Abstract

Amaç: Trombositler, akut koroner sendromun (AKS) patogenezinde önemli bir rol oynar ve trombosit dağılım genişliği (PDW), trombositlerin dolaşımdaki aktivitelerini gösterir. Bu çalışmanın amacı, PDW'nin AKS şiddeti, anjiyografik intrakoroner trombüs yükü ve Miyokard Enfarktüsünde Tromboliz (TIMI) akım derecesi ile ilişkisini belirlemektir. Gereç ve Yöntem: AKS tanısı alan ardışık 149 hasta geriye dönük olarak değerlendirildi. Akut Koroner Olayların Global Kayıtları (GRACE) skorları, AKS şiddeti için klinik ve laboratuvar verilerinden hesaplanmıştır. Suçlu koroner arterlerin TIMI akım dereceleri ve trombüs dereceleri her hasta için hesaplandı. Hastalar PDW değerlerine göre yüksek PDW ve düşük PDW olmak üzere iki gruba ayrıldı. İstatistiksel analiz için SPSS 17.0 programı kullanıldı. Bulgular: PDW, GRACE puanları ile korele bulundu (P<0.01). Yüksek PDW grubu daha yüksek GRACE skorlarına sahipti (139'a karşı 126, p<0.05). Yüksek PDW grubunda daha düşük TIMI akış dereceleri (0 ve 1) görüldü (39'a karşı 33, p<0.05). Çalışmamızda intrakoroner trombüs yükü ile PDW arasında ilişki bulunmadı (p=0,082). Sonuç: Çalışmamızda PDW düzeyi daha yüksek olan hastalar daha yaşlıydı ve GRACE skorları daha yüksek ve TIMI akış dereceleri daha düşüktü. PDW seviyeleri, AKS şiddeti ve TIMI akış derecesi ile ilişkilidir.

Keywords

• : Trombosit dağılım genişliği
• koroner trombüs
• TIMI akışı
• akut koroner sendrom

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