Evaluation of urine cotinine levels in children with chronic cough

Abstract

Bacground: Our study was planned to reveal the objective relation between urine cotinine level and tobacco smoke exposure in children suffering from chronic cough. Methods: Between ages 5-18 years, 58 patients with chronic cough with no underlying specific cause and 54 healthy individuals were included in the study. Results: There was a statistically significant difference between urine cotinine levels of cases those who exposed and unexposed (based on the declaration of parents) to tobacco smoke (p<0, 05). The highest mean value of cotinine (41.3±73.7) was detected in the cases of chronic cough group who exposed to smoke. The best “cut-off value” for discriminating exposed and unexposed group was found to be 12.15 ng/ml with ROC analysis. Smoking ratio during pregnancy has been found higher in the group with chronic cough (p<0, 05).FEV1/FVC ratio was found to be lower in patients with chronic cough who are passive smokers when compared with the cases in the other groups (p<0,05). Conclusions: This is the first study objectively evaluating chronic cough effect of passive smoking with urine cotinine level. Since there is a meaningful decrease in FEV1/FVC ratio, close follow up is needed especially in children diagnosed as chronic cough who are exposed to tobacco smoke.

Keywords

• biomarkers
• children
• chronic cough
• environmental tobacco smoke
• passive smoking
• urine cotinine level

Kronik öksürüklü çocukların idrar kotinin düzeyleri ile değerlendirilmesi

Abstract

Giriş ve amaç: Çalışmamız kronik öksürüklü çocuklarda idrar kotinin düzeyi ile sigara dumanı maruziyetini objektif olarak göstermek için planlandı. Gereç ve Yöntem: 5-18 yaş arası, kronik öksürüğü olan 58 ve sağlıklı 54 olmak üzere 112 çocuk çalışmaya dahil edildi. Bulgular: Ebeveyn beyanına göre sigara dumanına maruz kalan ve kalmayan olguların idrar kotinin düzeyleri arasında istatistiksel olarak anlamlı fark vardı (p<0, 05). En yüksek ortalama kotinin düzeyi (41.3±73.7) kronik öksürüğü olup sigaraya maruz kalan grupta saptandı. Sigara dumanına maruz kalan ve kalmayan grupları ayırt etmek için en iyi “cut-off” değeri (kesim noktası) ROC analizi ile 12.15 ng/ml olarak bulundu. Gebelikte sigara içme oranı kronik öksürüğü olan ve sigara dumanına maruz kalan grupta daha yüksek bulundu (p<0, 05). Pasif içici olan kronik öksürüğü olan çocuklarda FEV1/FVC oranı diğer gruplara göre daha düşük bulundu ( p<0,05). Sonuç: Bu, pasif içiciliğin çocuklarda kronik öksürük üzerine etkisini idrar kotinin düzeyi ile objektif olarak değerlendiren ilk çalışmadır. FEV1/FVC oranında anlamlı düşme nedeniyle tütün dumanına maruz kalan kronik öksürüklü çocuklarda yakın takip gereklidir.

Keywords

• biyobelirteçler
• çevresel tütün dumanı
• çocuk
• kronik öksürük
• pasif içicilik
• idrar kotinin düzeyi

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