X-Ray Cihazına Benzeyen Kan-Beyin Bariyerlerinin Çalışma Prensiplerini Açıklamaya Doğru: Bir Nörofizik Hipotez

Abstract

Amaç: Kan-beyin bariyeri, nörofiziksel temelde elektromanyetik bir mekanizmadır. Bu çalışmada kan-beyin bariyerini, ona birçok yönden benzeyen X-Ray cihazı ile karşılaştırdık. Gereç ve Yöntem: On sıçanın derin temporal korteks bölümlerinden beyin örnekleri topladık. Daha sonra glial fibriler asidik protein (GFAP) tekniği ile boyadık. Akabinde kan-beyin bariyerlerinin mimari yapılarını görselleştirdik ve X-ray cihazlarıyla karşılaştırdık. Bulgular: X-ray cihazında tüp kan-beyin bariyerini oluşturan arterioller ile elektrik akımını sağlayan ve akımın yönünü belirleyen anot-katot; damarları çevreleyen astrositlere, damarlar için soğutma sistemi örevi gören beyin omurilik sıvısına ve katottan damarda akan parçacıklara yayılan elektronlara karşılık gelir. Sonuç: Kan-beyin bariyerinin sunduğu mimari yapısı sayesinde yolcu bagajındaki nesneleri görüntüleyen ve barkod numaralarına göre yönlendiren bir X-Ray ve optik okuyucu olarak işlev gördüğünü düşünüyoruz.

Keywords

• Astrosit
• Kan-beyin bariyeri
• Glial fibriler asidik protein tekniği
• Sıçan
• X-ray cihazı

Toward to Explain of Working Principles of Blood-Brain Barriers Like X-Ray Devices: A Neurophysical Hypothesis

Abstract

Objective: The blood-brain barrier is an electromagnetic mechanism on a neurophysical basis. In this study, we compared the X-Ray device, which is similar to the blood-brain barrier in many ways. Material and Methods: We collected brain samples from deep temporal cortex sections of ten rats, stained them via the glial fibrillary acidic protein (GFAP) technique, visualized the architectural structures of the blood-brain barriers, and compared them with X-ray devices. Results: With the arterioles forming the tube blood-brain barrier in the X-ray device, the anode-cathode that provides the electric current and determines the direction of the current flow corresponds to the astrocytes surrounding the anode-cathode vessel, the cooling system to the cerebrospinal fluid circulating the vessel, and the electrons emitted from the cathode to the particles flowing in the vessel. Conclusion: With the architecture presented by the blood-brain barrier, we envision it functioning as an X-Ray and optical reader that display objects in passenger baggage and direct them according to barcode numbers.

Keywords

• Astrocyte
• Blood-brain barrier
• Glial fibrillary acidic protein technique
• Rat
• X-ray devices

References

1. 1. W.C. Rontgen. On a new kind of rays. Radiography. 1970;36(428):185-8.
2. 2. Attwood DT. Soft x-rays and extreme ultraviolet radiation: principles and applications. In: Attwood DT, editor. New York Cambridge Univ Press; 2000.
3. 3. Mahringer A, Puris E, Fricker G. Crossing the blood-brain barrier: A review on drug delivery strategies using colloidal carrier systems. Neurochem Int. 2021;147:105017.
4. 4. Daneman R, Prat A. The blood-brain barrier. Cold Spring Harb Perspect Biol. 2015;7(1):a020412.
5. 5. Cheslow L, Alvarez JI. Glial-endothelial crosstalk regulates blood-brain barrier function. Curr Opin Pharmacol. 2016;26:39-46.
6. 6. Abbott NJ, Patabendige AA, Dolman DE, Yusof SR, Begley DJ. Structure and function of the blood-brain barrier. Neurobiol Dis. 2010;37(1):13-25.
7. 7. Butt AM, Jones HC, Abbott NJ. Electrical resistance across the blood-brain barrier in anaesthetized rats: a developmental study. J Physiol. 1990;429:47-62.
8. 8. MB DHaS. The blood brain-barrier. In: Physiology of the CSF and of the Blood-Brain Barrier. New York CRC. 1995:49-91.

9. 9. Shapey J, Toma A, Saeed SR. Physiology of cerebrospinal fluid circulation. Curr Opin Otolaryngol Head Neck Surg. 2019;27(5):326-33.
10. 10. Nakada T, Kwee IL. Fluid Dynamics Inside the Brain Barrier: Current Concept of Interstitial Flow, Glymphatic Flow, and Cerebrospinal Fluid Circulation in the Brain. Neuroscientist. 2019;25(2):155-66.
11. 11. Kazakos EI, Kountouras J, Polyzos SA, Deretzi G. Novel aspects of defensins' involvement in virus-induced autoimmunity in the central nervous system. Med Hypotheses. 2017;102:33-6.
12. 12. de Laurentis C, Cristaldi P, Arighi A, Cavandoli C, Trezza A, Sganzerla EP, et al. Role of aquaporins in hydrocephalus: what do we know and where do we stand? A systematic review. J Neurol. 2020.
13. 13. Ignatyev K, Munro PRT, Chana D, Speller RD, Olivo A. A New Generation of X-ray Baggage Scanners Based on a Different Physical Principle. Materials (Basel). 2011;4(10):1846-60.