QT and P-Wave Dispersion of Patients with Antisocial Personality Disorder

Abstract

Background: The purpose was to examine the electrocardiographic arrhythmia risk determinants of the QT and P-wave dispersions of the patients who have Antisocial Personality Disorder (ASPD) by comparing them with the healthy control group. Method: A total of 52 patients who were diagnosed with ASPD according to DSM-5 Criteria and a healthy control group that consisted of 54 people were included in the study. Twelve lead Electrocardiograms (ECGs) were obtained from all participants in the supine position and at rest, and P-wave dispersion and QT dispersion were also calculated. The participants were administered the Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), Buss-Durke Aggression Scale (BDAS), Barratt Impulsivity Scale (BIS-11), and sociodemographic clinical data form. The SPSS version 22 package program was used for statistical analyses. Results: The mean age of the ASPD group and control group were no statistically significant differences between them (p=0.092). QT max (p=0.016), QTd (p<0.001), P max (p<0.001), and Pd (p<0.001) values of the ASPD group were higher than the values of the control group at significant levels; and QT min (p<0.001) and P min (p<0.001) values were found to be significantly lower. The BAI, BDI, BDAS scores and the motor impulsiveness score of the BIS-11 subscales of the ASPD group were significantly higher than those of the control group (p<0.001). Discussion: The findings of study showed that ASPD patients were at risk for electrical problems of the heart, especially cardiac arrhythmia, and this must be considered in the general psychiatric follow-up of these patients.

Keywords

• antisocial personality disorder
• QT dispersion
• P dispersion

Antisosyal Kişilik Bozukluğu Olan Hastalarda QT ve P Dalgası Dispersiyonu

Abstract

Amaç: Antisosyal kişilik bozukluğu (ASKB) olan hastalarda elektrokardiyografik aritmi risk belirleyicileri olan QT ve P dalgası dispersiyonlarının sağlıklı kontrol grubuyla karşılaştırılarak incelenmesi amaçlanmıştır. Yöntem: Çalışmamıza DSM-5 kriterlerine göre ASKB tanısı alan 52 hasta ve 54 kişiden oluşan sağlıklı kontrol grubu dahil edildi. Tüm katılımcıların boy, kiloları, tansiyonları ölçüldü ve vücud kitle indeksleri(VKİ) hesaplandı. Vücut kitle indeksi > 24,9 kg/m2 olan katılımcılar çalışma dışı bırakıldı. Tüm katılımcılardan on iki derivasyon elektrokardiyogramı (EKG) yatar pozisyonda ve istirahatte alındı. P dalga dispersiyonu ve QT dispersiyonu hesaplandı. Ayrıca katılımcılara Beck Anksiyete Ölçeği (BAÖ), Beck Depresyon Ölçeği (BDÖ), Buss-Durke Saldırganlık Ölçeği (BDSÖ), Barratt Dürtüsellik Ölçeği (BrDÖ) ve sosyodemografik klinik veri formu uygulandı. İstatiksel analizler için SPSS versiyon 22 paket programı kullanıldı. Sonuçlar: ASKB grubunda bulunanların yaş ortalaması 29,6±6,5, kontrol grubunun yaş ortalaması ise 31,8±7,1 olarak bulunmuş olup aralarında istatistiksel olarak anlamlı farklılık görülmemiştir (p=0,092). ASKB grubunun QT max (p=0,016), QT disp (p<0,001), P max (p<0,001), P disp (p<0,001) değeri kontrol grubunun değerlerinden anlamlı şekilde yüksek; QT min (p<0,001) ve P min (p<0,001) değeri ise anlamlı şekilde düşük bulunmuştur. ASKB grubunun BAÖ ve BDÖ puanı kontrol grubunun puanından anlamlı şekilde yüksek bulunmuştur (p<0,001). BDSÖ tüm alt ölçek puanları kontrol grubuna kıyasla daha yüksekti (p<0,001), BrDÖ alt ölçeklerinden ise motor dürtüsellik puanı ASKB grubunda daha yüksekti (p<0,001). Tartışma: Çalışma bulgularımız ASKB hastalarının kardiyak aritmi başta olmak üzere kalbin elektriksel temelli sorunları açısından risk taşıdıkları ve bu durumun bu hastaların genel psikiyatrik takibinde göz önünde bulundurulması gerektiğini göstermektedir.

Keywords

• antisosyal kişilik bozukluğu
• QT dispersiyonu
• P dispersiyonu

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