Tiroid Papiller Mikrokarsinomunda Prognostik Faktörler

Abstract

Amaç: Bu retrospektif çalışmadaki amacımız, tiroid papiller mikrokarsinom prognozunda önemli olan faktörleri değerlendirmektir. Gereç ve Yöntem: Çalışmaya Kütahya Sağlık Bilimleri Üniversitesi Evliya Çelebi Eğitim ve Araştırma Hastanesi Patoloji bölümünde, 2010-2020 yılları arasında tanı konulan, 178 hastaya ait 277 tiroid papiller mikrokarsinom nodülü dahil edildi. Tümör çapı, unilateralite, bilateralite, multifokalite, tümör odak sayısı, fibrozis, kapsüle uzaklık ve Gal-3, HBME-1 ve CK19 boyanmasının prognostik önemi olup olmadığını, lenfovasküler invazyon, lenf nodu metastazı, kapsül invazyonu ve tiroid dışı yayılım ile karşılaştırarak retrospektif olarak araştırıldı. Ayrıca immün boyalar ile fibrozis arasındaki ilişki araştırıldı. Bulgular: Tümör çapının >0,5 olması ve lenf nodu metastazı arasında anlamlı ilişki bulundu. Unilateralite, bilateralite, multifokalite ve tümör odak sayısı, lenfovasküler invazyon ve lenf nodu metastazı ile ilişkiliydi. Fibrozis, kapsül invazyonu ve ekstratiroidal yayılım ile ilişkiliydi. CK-19 prevalansı ve lenf nodu metastazı ile, Gal-3 prevalansı ve kapsüler invazyon ve tiroid dışı yayılım arasında ilişki bulundu. Fibrozis ile galektin3 ve CK19 yoğunlukları arasında pozitif, HBME-1 ile negatif korelasyon bulundu. Sonuç: Negatif prognostik belirteçler >0,5 tümör çapı, unilateralite, bilateralite, multifokalite, tümör odak sayısı, fibrozisdir. CK-19 prevalansı ve lenf nodu metastazı ile Gal-3 prevelansı ve kapsüler invazyon ve tiroid dışı yayılım arasında ilişki bulundu. Fibrozis ile galektin3 ve CK19 yoğunlukları arasında pozitif, HBME-1 ile negatif korelasyon bulundu. Anahtar Kelimeler: Tiroid papiller mikrokarsinom, prognoz, fibrozis, Gal-3, HBME-1, CK19, fibrozis.

Keywords

• Tiroid papiller mikrokarsinom
• prognoz
• Gal-3
• CK19
• fibrozis
• HBME-1

Prognostic Factors in Thyroid Papillary Microcarcinoma

Abstract

Aim: Our aim in this retrospective study is to evaluate the factors that are important in the prognosis of thyroid papillary microcarcinoma. Material and Method: This study is a retrospective study. In the study, 277 thyroid papillary microcarcinoma nodules belonging to 178 patients, diagnosed in Kütahya University of Health Sciences Hospital, between 2010 and 2020, were included. The prognostic significance of tumor diameter, unilaterality, bilaterality, multifocality, number of tumor foci, fibrosis, distance from the capsule and Gal-3, HBME-1 and CK19 staining were investigated retrospectively by comparing with negative prognostic factors such as lymphovascular invasion, lymph node metastasis, capsular invasion and extrathyroidal spread. Moreover, the relationship between immunostains and fibrosis was examined. Results: The significant association was found between >0.5 tumor diameter and lymph node metastasis. Unilaterality, bilaterality, multifocality and number of tumor foci was associated with lymphovascular invasion and lymph node metastasis. Fibrosis was associated with capsular invasion and extrathyroidal spread. A correlation was found between the prevalence of Gal- 3 and capsular invasion and extrathyroidal spread, and between the prevalence of CK-19 and lymph node metastasis. A positive correlation was found between fibrosis and Gal-3 and CK19, and negative correlations with HBME-1 intensity. Conclusion: Negative prognostic markers are >0.5 tumor diameter, unilaterality, bilaterality, multifocality, number of tumor foci, fibrosis, Gal-3 and CK19 prevalence. A positive correlation was found between fibrosis and Gal-3 and CK19, and negative correlation with HBME-1 intensity.

Keywords

• Thyroid papillary microcarcinoma
• prognosis
• Gal-3
• CK19
• fibrosis
• HBME-1

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