PRIMARY EBV INFECTION AND HEMATOLOGICAL FINDINGS IN TURKISH CHILDREN: A RETROSPECTIVE, SINGLE-CENTER STUDY

Abstract

Abstract Aim: Primary infection with EBV during childhood is usually asymptomatic. Hematologic abnormalities such as hemolytic anemia, thrombocytopenia, and neutropenia are relatively common, but aplastic anemia, severe thrombocytopenia, severe neutropenia, and lymphoid malignancies are rare. In this retrospective study, we have analyzed data from children with primary EBV infection who were examined at our center over 12 years to describe the distribution, clinical features, complications, and outcome of EBV in Turkish children. Materials and Methods: Data from all children (age<18 years) with primary EBV infection who were examined in our center between 2008 and 2020 were retrospectively reviewed. Results: In total, 120 patients were included in the study. Anemia was detected in 13 (11%) children. Mild and severe neutropenia was detected in 12 (10%) and 1 (0.8%) children, respectively. Mild thrombocytopenia without bleeding complications was present in 10 (8%) children with a mean platelet count of 250x109/L ±113x109/L. Seven patients presented with acute idiopathic thrombocytopenia (lowest platelet count, 2x109/L). Large diffuse cell lymphoma developed in 0.8% (n:1) patients. Conclusion: The prognosis for infectious mononucleosis is excellent, although various acute complications may occur. However, severe complications are very rare, and most of the complications resolve spontaneously without certain therapy.

Keywords

• Primary EBV infection
• Turkish children
• Hematologic findings

TÜRK ÇOCUKLARINDA PRİMER EBV ENFEKSİYONU VE HEMATOLOJİK BULGULARI: RETROSPEKTİF TEK MERKEZLİ BİR ÇALIŞMA

Abstract

Özet Amaç: Çocukluk döneminde EBV ile birincil enfeksiyon genellikle asemptomatiktir. Hemolitik anemi, trombositopeni ve nötropeni gibi hematolojik anormallikler nispeten yaygındır, ancak aplastik anemi, şiddetli trombositopeni, şiddetli nötropeni ve lenfoid maligniteler nadirdir. Bu retrospektif çalışmada, EBV'nin Türk çocuklarındaki dağılımını, klinik özelliklerini, komplikasyonlarını ve sonuçlarını tanımlamak için 12 yıl boyunca merkezimizde izlenen primer EBV enfeksiyonu olan çocuklardan elde edilen verileri analiz ettik. Gereç ve Yöntemler: Hastanemizde 2008-2020 yılları arasında izlenen primer EBV enfeksiyonlu tüm çocuklara (18 yaş altı) ait veriler retrospektif olarak incelendi. Bulgular: Çalışmaya toplam 120 hasta dahil edildi. 13 (%11) çocukta anemi saptandı. 12 (%10) çocukta hafif, 1 (%0,8) çocukta şiddetli nötropeni saptandı. Ortalama trombosit sayısı 250x109/L ±113x109/L olan 10 (%8) çocukta kanama komplikasyonu olmaksızın hafif trombositopeni mevcuttu. Yedi hasta akut idiyopatik trombositopeni (en düşük trombosit sayısı, 2x109/L) ile başvurdu. Hastaların %0,8'inde (n:1) büyük diffüz hücreli lenfoma gelişti. Tartışma: Çeşitli akut komplikasyonlar oluşabilmesine rağmen enfeksiyöz mononükleozun prognozu mükemmeldir. Bununla birlikte, ciddi komplikasyonlar çok nadirdir ve komplikasyonların çoğu belirli bir tedavi olmaksızın kendiliğinden düzelir.

Keywords

• Primer EBV enfeksiyonu
• Türk çocukları
• Hematolojik bulgular

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