Hemifasiyal Spazm Hastalarında Kafein Kullanımının Etkileri

Year 2023, , 706 - 710, 31.07.2023

Mehmet Kara , Soner Kılıç

https://doi.org/10.16899/jcm.1319884

Abstract

Öz
Amaç: Hemifasiyal spazm, fasiyal sinir tarafından innerve edilen kasların ilerleyici, istemsiz, düzensiz kasılması ile karakterizedir. Kafein, kas kasılmasını ve nörotransmitter salınımını artıran bir fitokimyasaldır. Bu çalışmanın amacı hemifasiyal spazmlı hastalarda kafein içeren gıda tüketiminin hastalık şiddeti ve hastalıkla ilişkili yaşam kalitesi üzerine etkilerini değerlendirmektir.
Gereç ve Yöntem: Nöroloji polikliniğine başvuran hemifasiyal spazm hastalarında; hemifasiyal spazm yaşam kalitesi ölçeği ve hemifasiyal spazm şiddet skalası prospektif olarak değerlendirildi. Hastaların günlük yiyecek ve içeceklerle aldıkları kafein miktarları belirlendi. Ölçek sonuçları ile tüketilen kafein miktarı arasındaki ilişki analiz edildi.
Bulgular: Çalışmaya 36 kadın (%60) ve 24 erkek (%40) olmak üzere toplam 60 hasta dahil edildi. Hastaların 59'unun (%98,3) yemekle birlikte ortalama 303±144 mg/gün kafein tükettiği belirlendi. Hemifasiyal spazm yaşam kalitesi ölçeği puanı 8,5 (4-21), hemifasiyal spazm şiddeti ölçeği 3 (1-4) olarak hesaplandı. Cinsiyete göre tüketilen kafein miktarı arasında anlamlı bir ilişki bulunmadı (p=0,066). Yaşa göre tüketilen kafein miktarı arasında negatif korelasyon bulundu (r=-0,291; p=0,024). Günlük kafein tüketimi ile hemifasiyal spazm yaşam kalitesi ölçeği ve hemifasiyal spazm şiddeti arasında anlamlı bir ilişki yoktu (p değerleri sırasıyla 0,297 ve 0,839). Hemifasiyal spazm yaşam kalitesi ölçeği ile hemifasiyal spazm şiddeti arasında pozitif yönde zayıf bir korelasyon vardır (r=0,291; p=0,024).
Sonuç: Hemifasiyal spazmlı hastalarda günlük yaşamda kafein içeren besinlerin tüketiminin spazm şiddetini ve yaşam kalitesini etkilemediği saptanmıştır.

Keywords

Hemifasiyal Spazm, Kafein, Teofilin

Effects of Caffeine Use in Hemifacial Spasm Patients

Abstract

Abstract
Objective: Hemifacial spasm is characterized by progressive, involuntary, irregular contraction of the muscles innervated by the facial nerve. Caffeine is a phytochemical that increases muscle contraction and neurotransmitter release. The aim of this study is to evaluate the effects of caffeine-containing food consumption on disease severity and disease-related quality of life in patients with hemifacial spasm.
Materials and Methods: In hemifacial spasm patients who applied to the neurology outpatient clinic; hemifacial spasm quality of life scale and hemifacial spasm severity scale were evaluated prospectively. The amount of caffeine taken by the patients with daily food and beverage was determined. The relationship between the results of the scales and the amount of caffeine consumed was analyzed.
Results: A total of 60 patients, 36 women (60%) and 24 men (40%), were included in the study. It was determined that 59 of the patients (98.3%) consumed an average of 303±144 mg/day of caffeine with food. The hemifacial spasm quality of life scale score was calculated as 8.5 (4-21) and the hemifacial spasm severity scale was calculated as 3 (1-4). No significant correlation was found between the amount of caffeine consumed by gender (p=0.066). A negative correlation was found between the amount of caffeine consumed by age (r=-0.291; p=0.024). There was no significant relationship between daily caffeine consumption and hemifacial spasm quality of life scale and hemifacial spasm severity (p values 0.297 and 0.839, respectively). There is a weak positive correlation between the hemifacial spasm quality of life scale and the severity of hemifacial spasm (r=0.291; p=0.024).
Conclusion: It has been determined that the consumption of foods containing caffeine in daily life does not affect the severity of spasm and quality of life in patients with hemifacial spasm.

Keywords

Hemifacial Spasm, Caffeine, Theophylline

References

• 1. Wang A, Jankovic J. Hemifacial spasm: clinical findings and treatment. Muscle Nerve. 1998;21(12):1740-1747.
• 2. Nielsen VK. Electrophysiology of the facial nerve in hemifacial spasm: ectopic/ephaptic excitation. Muscle Nerve. 1985;8(7):545-555.
• 3. Chaudhry N, Srivastava A, Joshi L. Hemifacial spasm: The past, present and future. J Neurol Sci. 2015;356(1-2):27-31.
• 4. Camandola S, Plick N, Mattson MP. Impact of Coffee and Cacao Purine Metabolites on Neuroplasticity and Neurodegenerative Disease. Neurochem Res. 2019;44(1):214-227.
• 5. Qi H, Li S. Dose-response meta-analysis on coffee, tea and caffeine consumption with risk of Parkinson's disease. Geriatr Gerontol Int. 2014;14(2):430-9.
• 6. Graham TE. Caffeine and exercise: metabolism, endurance and performance. Sports Med. 2001;31(11):785-807.
• 7. Nehlig A. Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption. Pharmacol Rev. 2018;70(2):384-411.
• 8. Chen RS, Lu CS, Tsai CH. Botulinum toxin A injection in the treatment of hemifacial spasm. Acta Neurol Scand. 1996;94(3):207-211.
• 9. Tanuma A, Saito S, Ide I, et al. Caffeine enhances the expression of the angiotensin II Type 2 receptor mRNA in BeWo cell culture and in the rat placenta. Placenta. 2003;24(6):638-647.
• 10. Tanda G, Goldberg SR. Alteration of the behavioral effects of nicotine by chronic caffeine exposure. Pharmacol Biochem Behav. 2000;66(1):47-64.
• 11.Nehlig A, Boyet S. Dose-response study of caffeine effects on cerebral functional activity with a specific focus on dependence. Brain Res. 2000;858(1):71-77.
• 12. Fredholm BB, Bättig K, Holmén J, Nehlig A, Zvartau EE. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev. 1999;51(1):83-133.
• 13. Tan EK, Fook-Chong S, Lum SY, Thumboo J. Validation of a short disease specific quality of life scale for hemifacial spasm: correlation with SF-36. J Neurol Neurosurg Psychiatry. 2005;76(12):1707-1710.
• 14. Peeraully T, Tan SF, Fook-Chong SM, Prakash KM, Tan EK. Headache in hemifacial spasm patients. Acta Neurol Scand. 2013;127(5):e24-e27.
• 15. Lorist MM, Tops M. Caffeine, fatigue, and cognition. Brain Cogn. 2003;53(1):82-94.
• 16. George KC, Hebbar SA, Kale SP, Kesavan PC. Caffeine protects mice against whole-body lethal dose of gamma-irradiation. J Radiol Prot. 1999;19(2):171-176.