Taste Alteration in Children with Cancer Before and During Chemotherapy
Year 2025,
Volume: 15 Issue: 3, 132 - 138, 31.05.2025
Sabiha Uvalı
,
Elif Bilsin Kocamaz
Abstract
Aim: This study was conducted to investigate the taste alteration before and during chemotherapy in children with cancer.
Materials and Methods: It is a descriptive and cross-sectional study. The population of the study consisted of children aged 8-18 years who were followed up and received chemotherapy in the pediatric hematology and oncology clinic of a University Medical Faculty Oncology Hospital. A Child Description Form, the Taste Alteration Scale for Children Receiving Chemotherapy (TAS-CRC) and the Scale of Subjective Total Taste Acuity (SSTTA) were used to collect the data.
Results: It was determined that 13.3% of the children before chemotherapy, 53.3% in the 3rd week of chemotherapy and 66.7% in the 6th week of chemotherapy experienced taste changes. It was determined that there was a statistically significant difference between the mean scores of the TAS-CRC administered before chemotherapy and at the 3rd and 6th week of chemotherapy. In addition, taste acuity was found to be higher in the 3rd and 6th week of chemotherapy compared to before chemotherapy.
Conclusion: It was determined that both taste alteration and taste acuity in children were higher in the 3rd and 6th week of chemotherapy compared to pre-chemotherapy. Since taste alteration and increased taste acuity in children undergoing chemotherapy can adversely affect their nutrition, children should be regularly monitored in terms of height, weight, and Body Mass Index (BMI).
Ethical Statement
Written approval for the research was obtained before commencement from the institution where it was conducted and from a University clinical research ethical committee (IRB approval period: between February 2021 and September 2022) (IRB No. 2020/296). Verbal and written consent to participation was obtained once information concerning the research had been given to the children and their parents before data collection commenced.
References
-
1. Van den Brink M, IJpma I, van Belkom B, Fiocco M, Havermans RC, Tissing WJE. Smell and taste function in childhood cancer patients: A feasibility study. Support Care Cancer. 2020;29(3):1619-1628.
-
2. Drareni K, Dougkas A, Giboreau A, Laville M, Souquet PJ, Bensafi M. Relationship between food behavior and taste and smell alterations in cancer patients undergoing chemotherapy: A structured review. Semin Oncol. 2019;46(2):160-172.
-
3. Loves R, Green G, Joseph-Frederick Z, Palmert S, Plenert E, Schechter T, et al. Describing taste changes and their potential impacts on paediatric patients receiving cancer treatments. BMJ Support Palliat Care. 2023; 7;13(e2):e382-e388.
-
4. Boltong A, Keast R, Aranda S. Talking about taste: how do oncology clinicians discuss and document taste problems?. Cancer Forum. 2011;35(2).
-
5. Van den Brink M, IJpma I, Tissing WJE, Havermans RC. Taste dysfunction in children-a clinical perspective and review of assessment methods. Chem Senses. 2021;1;46:1-10.
-
6. Guru HR, Koul R, Aiman A, Zargar OA, Zargar10 OA. Nutritional profile and management of pediatric oncology patients at a tertiary care hospital from Kashmir: Where do we stand?.International Journal of Health and Clinical Research. 2021;4(16):66-68.
-
7. Çanga N. (2013). Determination of changes in taste and nutritional status of children with solid tumor having chemotherapy. (Unpublished master's thesis), Hacettepe University, Ankara.
-
8. Pang D, Qian L, Chen ZJ, Lu Q, Heitkemper MM, Yang P, et al. Psychometric properties of the Chinese version of the chemotherapy-induced taste alteration scale. Eur J Oncol Nurs. 2019;42:7-13.
-
9. Bilsin E, Bal Yilmaz H. Development and validation of the taste alteration scale forchildren receiving chemotherapy. J Res Nurs. 2018;23(7):568-580
-
10. Murtaza B, Hichami A, Khan AS, Ghiringhelli F, Khan NA. Alteration in taste perception in cancer: causes and strategies of treatment. Front Physiol. 2017;8:134.
-
11. Rawat N, Chanu SE, Chauhan V. Chemotherapy associated side effects among children with cancer. International Journal of Health Sciences and Research. 2021;11(2):236-242.
-
12. Epstein JB, de Andrade ESSM, Epstein GL, Leal JHS, Barasch A, Smutzer G. Taste disorders following cancer treatment: report of a case series.Support Care Cancer. 2019;27(12):4587-4595.
-
13. Rubin P, Constine LS, Fajardo LF, Phillips TL, Wasserman TH. RTOG Late Effects Working Group. Overview. Late Effects of Normal Tissues (LENT) scoring system.Int J Radiat Oncol Biol Phys. 1995;30;31(5):1041-2.
-
14. Child Metrics [Internet]. [cited 2017]. Available from: https://www.ceddcozum.com/
-
15. Sülger Bicici D, Bilsin Kocamaz E. Taste alteration, food habits and nutritional status of childhood cancer survivors. J Contemp Med 2024;14(6):309-314.
-
16. Rehwaldt M, Wickham R, Purl S, Tariman J, Blendowski C, Shott S,et al. Self-care strategies to cope with taste changes after chemotherapy. Oncol Nurs Forum. 2009;36(2):E47-56.
-
17. Feng S, Cheng L, Lu H, Shen N. Nutritional status and clinical outcomes in children with cancer on admission to intensive care units. Nutr Cancer. 2021;73(1):83-88.
-
18. Skolin I, Wahlin YB, Broman DA, Koivisto Hursti UK, Vikstrom Larsson M, Hernell O. Altered food intake and taste perception in children with cancer after startof chemotherapy: perspectives of children, parents and nurses. Support Care Cancer. 2006;14(4):369-378.
-
19. American Cancer Society. Taste and smell changes. 2020 [updated 2020 Feb 1; cited 2022 Dec 21]. https://www.cancer.org/cancer/managing-cancer/side-effects/eating-problems/taste-smell-changes.html
-
20. Fistikci Y, Bilsin Kocamaz E. Eating behavior, nutritional status, and taste perception alteration in children with cancer. J Pediatr Hematol Oncol, 2024;46:88–95.
-
21. Karaman N. Chemoterapy induced taste and smell changes in pediatric cancerpatients. Turkish Journal of Oncology. 2013;28(3):101-104.
-
22. Alelayan H, Wen H, Li H, Ge J, Han W, Liao X. The therapy-related symptom checklist for children as a method for monitoring symptoms in chinese children with cancer: Linguistic validation and cross-cultural adaptation. Pain Manag Nurs. 2022;23(6):855-860.
Kanserli Çocuklarda Kemoterapi Öncesi ve Kemoterapi Sırasında Tat Alma Değişikliği
Year 2025,
Volume: 15 Issue: 3, 132 - 138, 31.05.2025
Sabiha Uvalı
,
Elif Bilsin Kocamaz
Abstract
Amaç: Bu çalışma kanserli çocuklarda kemoterapi öncesi ve kemoterapi sırasında tat alma değişikliğini incelemek amacıyla yapılmıştır.
Gereç ve Yöntem: Tanımlayıcı ve kesitsel tipte bir araştırmadır. Araştırmanın evrenini bir Üniversitenin Tıp Fakültesi Onkoloji Hastanesi pediatri hematoloji ve onkoloji kliniğinde izlenen ve kemoterapi alan 8-18 yaş arasındaki çocuklar oluşturmuştur. Verilerin toplanmasında Çocuk Tanıtım Formu, Kemoterapi Alan Çocuklar İçin Tat Alma Değişikliği Ölçeği (KAÇ-TADÖ) ve Subjektif Total Tat Keskinliği Ölçeği (STTKÖ) kullanılmıştır.
Bulgular: Çocukların kemoterapi öncesinde %13.3’nün, kemoterapinin 3. haftasında %53.3’ünün ve kemoterapinin 6. haftasında %66.7’sinin tat alma değişikliği yaşadığı belirlenmiştir. Kemoterapi öncesi, kemoterapinin 3. ve 6. haftasında uygulanan KAÇ-TADÖ puan ortalamaları arasında istatistiksel olarak anlamlı fark olduğu belirlenmiştir. Ayrıca kemoterapi öncesine göre kemoterapinin 3. ve 6. haftasında tat keskinliği kaybının daha fazla olduğu saptanmıştır.
Sonuç: Çocuklarda hem tat alma değişikliğinin hem de tat keskinliğinin kemoterapi öncesine göre kemoterapinin 3. ve 6. haftasında daha fazla olduğu belirlenmiştir. Kemoterapi alan çocuklarda tat alma değişikliği ve tat keskinliği beslenmelerini olumsuz yönde etkileyebileceğinden, çocukların boy, kilo ve Beden Kitle İndeksi (BKİ) açısından düzenli olarak izlenmesi gerekir.
References
-
1. Van den Brink M, IJpma I, van Belkom B, Fiocco M, Havermans RC, Tissing WJE. Smell and taste function in childhood cancer patients: A feasibility study. Support Care Cancer. 2020;29(3):1619-1628.
-
2. Drareni K, Dougkas A, Giboreau A, Laville M, Souquet PJ, Bensafi M. Relationship between food behavior and taste and smell alterations in cancer patients undergoing chemotherapy: A structured review. Semin Oncol. 2019;46(2):160-172.
-
3. Loves R, Green G, Joseph-Frederick Z, Palmert S, Plenert E, Schechter T, et al. Describing taste changes and their potential impacts on paediatric patients receiving cancer treatments. BMJ Support Palliat Care. 2023; 7;13(e2):e382-e388.
-
4. Boltong A, Keast R, Aranda S. Talking about taste: how do oncology clinicians discuss and document taste problems?. Cancer Forum. 2011;35(2).
-
5. Van den Brink M, IJpma I, Tissing WJE, Havermans RC. Taste dysfunction in children-a clinical perspective and review of assessment methods. Chem Senses. 2021;1;46:1-10.
-
6. Guru HR, Koul R, Aiman A, Zargar OA, Zargar10 OA. Nutritional profile and management of pediatric oncology patients at a tertiary care hospital from Kashmir: Where do we stand?.International Journal of Health and Clinical Research. 2021;4(16):66-68.
-
7. Çanga N. (2013). Determination of changes in taste and nutritional status of children with solid tumor having chemotherapy. (Unpublished master's thesis), Hacettepe University, Ankara.
-
8. Pang D, Qian L, Chen ZJ, Lu Q, Heitkemper MM, Yang P, et al. Psychometric properties of the Chinese version of the chemotherapy-induced taste alteration scale. Eur J Oncol Nurs. 2019;42:7-13.
-
9. Bilsin E, Bal Yilmaz H. Development and validation of the taste alteration scale forchildren receiving chemotherapy. J Res Nurs. 2018;23(7):568-580
-
10. Murtaza B, Hichami A, Khan AS, Ghiringhelli F, Khan NA. Alteration in taste perception in cancer: causes and strategies of treatment. Front Physiol. 2017;8:134.
-
11. Rawat N, Chanu SE, Chauhan V. Chemotherapy associated side effects among children with cancer. International Journal of Health Sciences and Research. 2021;11(2):236-242.
-
12. Epstein JB, de Andrade ESSM, Epstein GL, Leal JHS, Barasch A, Smutzer G. Taste disorders following cancer treatment: report of a case series.Support Care Cancer. 2019;27(12):4587-4595.
-
13. Rubin P, Constine LS, Fajardo LF, Phillips TL, Wasserman TH. RTOG Late Effects Working Group. Overview. Late Effects of Normal Tissues (LENT) scoring system.Int J Radiat Oncol Biol Phys. 1995;30;31(5):1041-2.
-
14. Child Metrics [Internet]. [cited 2017]. Available from: https://www.ceddcozum.com/
-
15. Sülger Bicici D, Bilsin Kocamaz E. Taste alteration, food habits and nutritional status of childhood cancer survivors. J Contemp Med 2024;14(6):309-314.
-
16. Rehwaldt M, Wickham R, Purl S, Tariman J, Blendowski C, Shott S,et al. Self-care strategies to cope with taste changes after chemotherapy. Oncol Nurs Forum. 2009;36(2):E47-56.
-
17. Feng S, Cheng L, Lu H, Shen N. Nutritional status and clinical outcomes in children with cancer on admission to intensive care units. Nutr Cancer. 2021;73(1):83-88.
-
18. Skolin I, Wahlin YB, Broman DA, Koivisto Hursti UK, Vikstrom Larsson M, Hernell O. Altered food intake and taste perception in children with cancer after startof chemotherapy: perspectives of children, parents and nurses. Support Care Cancer. 2006;14(4):369-378.
-
19. American Cancer Society. Taste and smell changes. 2020 [updated 2020 Feb 1; cited 2022 Dec 21]. https://www.cancer.org/cancer/managing-cancer/side-effects/eating-problems/taste-smell-changes.html
-
20. Fistikci Y, Bilsin Kocamaz E. Eating behavior, nutritional status, and taste perception alteration in children with cancer. J Pediatr Hematol Oncol, 2024;46:88–95.
-
21. Karaman N. Chemoterapy induced taste and smell changes in pediatric cancerpatients. Turkish Journal of Oncology. 2013;28(3):101-104.
-
22. Alelayan H, Wen H, Li H, Ge J, Han W, Liao X. The therapy-related symptom checklist for children as a method for monitoring symptoms in chinese children with cancer: Linguistic validation and cross-cultural adaptation. Pain Manag Nurs. 2022;23(6):855-860.