Relationship Between Blood Gas and NT-ProBNP in Patients Presenting with Dyspnea

Abstract

Background: Dyspnea can be caused by different systems, and the negative predictive value of N_terminal pro-brain natriuretic peptide (NT-proBNP) is indicative of heart failure. We aimed to evaluate the relationship between blood gases and NT-proBNP in patients presenting with dyspnea and to determine the guiding factors in the differential diagnosis. Methods: Patients admitted to our hospital with dyspnea and who underwent NT-proBNP and venous blood gas tests at the same time were included in the study. Demographic data, comorbidities, and laboratory data were recorded. The relationship between NT-proBNP and venous blood gas parameters was evaluated. p<0.05 was considered significant. Results: The mean age of the 523 patients was 74±12.83 years, with 50.3% of the patient population identified as male. In the total group, NT-proBNP demonstrated a positive correlation with age (p < 0.001) and a negative correlation with current bicarbonate (cHCO3) (p < 0.001), standard bicarbonate (HCO3) (p < 0.001), pCO2 (p = 0.022), and BE (p < 0.001). In patients with chronic kidney disease (CKD), NT-proBNP demonstrated a moderately negative correlation with cHCO3 (p = 0.008), HCO3 (p = 0.019), and BE (p = 0.010). In patients with heart failure (HF), there was a moderate negative association between NT-proBNP and cHCO3 (p = 0.002), HCO3 (p = 0.001), and BE (p = 0.001). Conclusion: In the absence of definitive evidence of heart failure in a dyspneic patient, it is reasonable to consider the potential contribution of impaired renal function to the overall evaluation.

Keywords

• Nt-proBNP
• venous blood gas
• heart failure
• chronic kidney disease

Dispne ile Başvuran Hastalarda Kan Gazı ve NT-ProBNP İlişkisi

Abstract

Background: Dispne farklı sistemlerden kaynaklanabilen bir bulgu olup N_terminal pro brain natriüretik peptid (NT-proBNP)’in negatif prediktif değeri kalp yetmezliği için yol göstericidir. Aim: Nefes darlığı şikayeti ile başvuran hastalarda kan gazı ve NT-proBNP arasındaki ilişkiyi değerlendirerek ayırıcı tanıda yol gösterici faktörleri belirlemeyi amaçladık. Materials and Methods Çalışmaya dispne ile hastanemize başvuran ve NT-proBNP ve venöz kan gazı tetkikleri aynı zamanda yapılan hastalar alındı. Demografik verileri, eşlik eden hastalıkları ve laboratuvar verileri kaydedildi. NT-proBNP ve venöz kan gazı parametreleri arasındaki ilişki değerlendirildi. p<.05 anlamlı kabul edildi. Results Çalışmaya katılan 523 hastanın yaş ortalaması 74±12.83 yıl olup %50.3’ü erkekti. Total grupta NT-proBNP ile yaş (p<.001) arasında pozitif yönde, aktüel bikarbonat (cHCO3) (p<.001), standart bikarbonat (HCO3) (p<.001), pCO2 (p=.022) ve BE (p<.001) ile negatif yönde anlamlı korelasyon bulundu. Kronik böbrek hastalığı (CKD) olanlarda NT-proBNP ile cHCO3 (p=.008), HCO3 (p=.019), BE (p=.010) orta düzeyde negatif yönde ilişki vardı. Kalb yetmezliği (HF) olanlarda NT-proBNP ile cHCO3 (p=.002), HCO3 (p=.001), BE (p=.001) arasında orta düzeyde negatif yönde ilişki vardı. Conclusion Dispneik hastanın NT-proBNP ve kan gazları değerleri kesin kalp yetmezliğine işaret etmiyorsa, böbrek fonksiyonlarındaki bozulmanın değerlendirme denklemine katılması uygun görünmektedir.

Keywords

• Nt-proBNP
• venöz kan gazı
• kalp yetmezliği

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