Nöroblastomda tek merkez deneyimi, cerrahi sonuçlar ve komplikasyonlar

Abstract

Özet Arka Plan/Amaçlar: Nöroblastom (NB), periferik sinir sisteminin embriyonal nöroendokrin tümörüdür. Çocukluk çağının en sık görülen ekstrakraniyal solid tümörüdür ve yaşamın ilk yılında en sık görülür. İyi huylu bir seyirden ölümcül bir hastalığa kadar değişen değişken bir seyir gösterir Yöntemler: Ocak 2012 ile Aralık 2021 arasında merkezimizde nöroblastom nedeniyle cerrahi rezeksiyon geçiren 18 yaş altı kırk hasta çalışmaya dahil edildi. Hastaların demografik verileri, ameliyat öncesi kesitsel ve fonksiyonel görüntüleme, cerrahi prosedürler, cerrahi komplikasyonlar ve patolojik evreleme retrospektif olarak analiz edildi. Sonuçlar: Bu retrospektif çalışmada 48 hasta analiz edildi. 48 hastanın %52,5'i erkek ve %47,5'i kadındı. Hastaların %82,5'inde elle muayene edilebilen abdominal kitle tespit edildi. 0 hasta nöroblastoma, 10 hasta ganglionöroblastoma ve 8 hasta ganglionöroma idi. Ganglionöroma olan sekiz hasta çalışmadan hariç tutuldu. Analiz 40 hasta arasında yapıldı. Sonuçlar: NB klinik davranışta heterojendir. Hastalığın evresi, hastanın yaşı ve risk faktörleri dikkate alınarak, pediatrik cerrah tarafından minimal komplikasyonlarla tedavi edilir. Tümör sempatik sinir sisteminden kaynaklandığı ve çevredeki büyük damarları ve çevre dokuları istila ettiği için, ameliyattan sonra agresif kemoterapi ve lokal bölgesel radyoterapi gerekebilir. Ameliyatı kişiselleştirerek ciddi komplikasyonlardan kaçınmak mümkün olabilir.

Keywords

• nöroblastom,
• cerrahi
• klinik davranış

Single center experience in neuroblastoma, surgical results and complications

Abstract

Abstract Background/Aims: Neuroblastoma (NB) is an embryonal neuroendocrine tumor of the peripheral nervous system. It is the most common extracranial solid tumor of childhood and the most common in the first year of life.It has a variable course ranging from a benign course to a fatal disease Methods: Forty patients under the age of 18 who underwent surgical resection in our center due to neuroblastoma between January 2012 and December 2021 were included in to the study. Demographic data of the patients, preoperative cross-sectional and functional imaging, surgical procedures, surgical complications and pathological staging were analyzed retrospectively. Results: In this retrospective study, 48 patients were analyzed. Of 48 patients 52.5% were male and 47.5% were female. palpable abdominal mass detected in 82.5% of the patients. 0 patients were neuroblastoma, 10 patients were ganglioneuroblastoma, and 8 patients were ganglioneuromas. Eight patients with ganglioneuroma were excluded from the study. Analysis was performed among 40 patients. Conclusions: NB is heterogeneous in clinical behavior. It is treated by the pediatric surgeon with minimal complications, taking into account the stage of the disease, the age of the patient, and risk factors. Since the tumor originates from the sympathetic nervous system and invades surrounding large vessels and surrounding tissues, aggressive chemotherapy and local regional radiotherapy may be required after surgery. It may be possible to avoid serious complications by customizing the surgery.

Keywords

• neuroblastoma
• surgery
• clinical behavior
• survival

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