Hematoloji-Onkoloji Hastaları ile İmmünsüprese Hastalarda Su Çiçeği Enfeksiyonu Klinik Sonuçları

Abstract

Giriş Suçiçeği (varisella), çocukluk çağının en sık görülen bulaşıcı hastalıklardan biri olmasına rağmen, özellikle immün sistemi baskılanmış hastalarda önemli mortalite ve morbiditeye yol açmaktadır. Bu çalışmada, hematolojik/onkolojik hastalıklar (Grup A) veya diğer nedenlerle (Grup B) immün sistemi baskılanmış hastaların komplikasyonları, hastanede kalış süreleri, antibiyotik ve asiklovir kullanımı ve yoğun bakım ihtiyaçlarının karşılaştırmalı olarak değerlendirilmesi amaçlanmıştır. Gereç ve Yöntemler İstanbul Medeniyet Üniversitesi Göztepe Eğitim ve Araştırma Hastanesi Çocuk Enfeksiyon Hastalıkları Kliniği'nde 2008-2016 yılları arasında suçiçeği enfeksiyonu tanısı alan hastaların tıbbi kayıtları retrospektif olarak incelenmiştir. Hematolojik/onkolojik hastalıklar veya diğer nedenlerle immün sistemi baskılanmış hastalar çalışmaya dahil edilmiştir. Bulgular Çalışmaya toplam 68 hasta dahil edilmiştir. Hastaneye yatışlar ilkbahar ve yaz aylarının başında en yüksek seviyeye ulaşmıştır. Akut lenfoblastik lösemi, Grup A'da en sık görülen tanı olarak saptanmıştır. Sepsis, Grup A'da daha sık görülürken, cilt enfeksiyonu Grup B'de daha sık görülmüştür. Sepsis ve asiklovir kullanımının Grup A'da anlamlı olarak daha sık olduğu saptanmıştır. Sonuç Sonuç olarak, bu çalışma, immünsüpresif hastalarda su çiçeği enfeksiyonunda erken antiviral tedavinin daha az morbidite ve mortalite ile daha iyi prognoz sağlamak için önemini vurgulamaktadır.

Keywords

• İmmunsüprese
• su çiçeği
• asiklovir
• hematoloji
• onkoloji

Project Number

2017/0078

Comparative Clinical Outcomes of Varicella Infection in Immunosuppressed Pediatric Patients: Hematology-Oncology vs. Other Causes

Abstract

Aim Varicella infection (chickenpox) is one of the most common infectious diseases in childhood, yet it may lead significant mortality and morbidity, especially among immunosuppressed patients. This study aims to carry out a comparative evaluation of complications, duration of hospitalization, antibiotic and acyclovir use and intensive care need of patients who were immunosuppressed due to hematological/oncological diseases (Group A) or due to other causes (Group B). Materials and Methods The medical records of the patients diagnosed with Varicella infection at Istanbul Medeniyet University Göztepe Education and Research Hospital Pediatric Infectious Diseases Clinic between 2008 and 2016 are retrospectively evaluated. Patients who were immunosuppressed due to hematological/oncological diseases or due to other causes were included in the study. Results A total of 68 patients unrolled to the study. Hospitalization peaked in spring and early summer. Acute lymphoblastic leukemia was the most common diagnosis in Group A. Sepsis was more frequent in Group A while skin infection was observed more commonly in Group B. The results revealed that sepsis and acyclovir use was significantly more frequent in Group A, Conclusion In conclusion, this study emphasizes the importance of early antiviral therapy for providing favorable prognosis with less morbidity and mortality in varicella infection in immunosuppressed patients.

Keywords

• immunosuppressed
• varicella
• acyclovir
• hematology
• oncology

Supporting Institution

Istanbul Medeniyet University

Project Number

2017/0078

Ethical Statement

Approval was granted by the Ethics Committee of Istanbul Medeniyet University Göztepe Education and Research Hospital

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