Yaşlı Hipertensif Hastalarda Kullanılan Beta Blokerler Cilt Kanserlerinin Riski Azaltır Mı?

Abstract

Beta blokerler çoğunlukla yıllarca kardiyovasküler sağlık sorunlarının tedavisinde kullanılan ilaçlardır.Diğer bilinen endikasyonları migren, anksiyete, tirotoksikoz ve infantil hemanjiyomlardır. Bunlara ek olarak, son çalışmalar, muhtemelen tümör ilerlemesi için gerekli olan adrenerjik ve anjiyogenez bloke edici etkileri nedeniyle antikanser özelliklere sahip olduğunu göstermektedir. Prostat, meme, yumurtalık, küçük hücreli dışı akciğer kanserleri veya melanoması olan hastaların beta bloker tedavilerden yararlandıkları gösterilmiştir. Bu verilere bağlı olarak, son iki yılda premalign cilt lezyonları ve melanom dışı cilt kanserli hastaların antihipertansif ilaç öyküsünü araştırdık. Çalışmamızda antihipertansif ajan olarak beta bloker kullanan hastaların daha az solar keratoz ve bazal hücre kanserleri olduğunu gördük.

Could beta blocker use in elderly hypertensive patients reduce risk of skin cancers?

Abstract

Beta blokers are commonly used medications mainly in the treatment of cardiovascular health problems for years.Other known indications are migraine,anxiety,thyrotoxicosis and infantile hemangiomas.In addition to these,recent studies showes they have anticancer properties probably due to their adrenergic and angiogenesis blocking effects which are essential for tumor progression.Patients with prostate,breast,ovarian,non-small cell lung cancers or melanoma were demonstrated getting benefit from beta blocer treatments.Depending on these data,we searched antihypertensive drug history of patients with premalignant skin lesions and non-melanoma akin cancers at past two years.We observed that patients using beta blockers as antihypertensive agent had less solar keratosis and basal cell cancers during the our study.

Keywords

• Beta blockers,Skin cancer

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