Fibromyalgia frequency and course in renal transplantation patients

Abstract

Abstract

Background/Aims: Musculoskeletal complications such as fibromyalgia syndrome may occur following renal transplantation. However, frequency and the course of this condition have not been deeply assessed in this group of patients. This study aimed to investigate the frequency of fibromyalgia syndrome and identify the factors associated with its occurrence in patients who underwent renal transplantation for end-stage renal disease. 

Methods: The demographic, clinical, and laboratory characteristics were recorded. All patients were assessed in outpatient setting for the presence of fibromyalgia and classified into three groups in the following order: Group 1, normal patients; Group 2, possible fibromyalgia; Group 3, fibromyalgia syndrome. In addition, Fibromyalgia Impact Questionnaire was administered.

Results: A total of 128 patients who underwent renal transplantation were included. Three groups did not differ with regard to the age, marital status, smoking history, etiology of the renal failure and laboratory findings (p>0.05). However, female gender was more frequent among patients with fibromyalgia. Fatigue, sleep disturbance, irritable colon syndrome, depression and antidepressant use were also more common and Fibromyalgia Impact Questionnaire score was higher in patients with fibromyalgia. A multivariate logistic regression analysis identified Fibromyalgia Impact Questionnaire score and antidepressant use as significant independent predictors of fibromyalgia syndrome and possible fibromyalgia.

Conclusion: Fibromyalgia syndrome shows a tendency to occur more commonly in renal transplant patients than in normal population, where depression is accompanied by these conditions. Fibromyalgia Impact Questionnaire scoring system is a useful tool to assess the presence of fibromyalgia syndrome or possible fibromyalgia syndrome in this group of patients.

Keywords

• Fibromyalgia,Questionnaires,End-Stage Renal Disease,Renal Transplantation

References

1. 1. Theadom A, Cropley M, Humphrey KL. Exploring the role of sleep and coping in quality of life in fibromyalgia. J Psychosom Res. 2007;62:145–151. https://doi.org/10.1016/j.jpsychores.2006.09.013
2. 2. Özcan DS, Aras M, Köseoğlu BF, Güven SS. Fibromyalji sendromlu kadın hastalarda yaşam kalitesi ve ilişkili durumlar. Türk Osteoporoz Dergisi. 2013;19:42–47. https://doi.org/10.4274/tod.38258.
3. 3. Uçeyler N, Häuser W, Sommer C. A systematic review on the effectiveness of treatment with antidepressants in fibromyalgia syndrome. Arthritis Rheum. 2008;59:1279–1298. https://doi.org/10.1002/art.24000.
4. 4. Kosek E. Fibromyalgia. In: Schenck-Gustafsson K, DeCola PR, Pfaff DW, Pisetsky DS, eds: Handbook of Clinical Gender Medicine. Basel: Karger; 2012,164–168.
5. 5. Dönmez A, Erdoğan N. Fibromiyalji sendromu. Klinik Gelişim. 2009;22:60–64.
6. 6. Koçyiğit BF, Gür A, Altındağ Ö, Akyol A, Gürsoy S. Comparison of education and balneotherapy efficacy in patients with fibromyalgia syndrome: a randomized, controlled clinical study. Agri. 2016;28:72–78. https://doi.org/10.5505/agri.2015.77699.
7. 7. Buskila D, Sarzi-Puttini P. Genetic aspects of fibromyalgia syndrome. Arthritis Res Ther. 2006;8:218.
8. 8. Çavdar İ, Aksoy G, Kamber A, Akyolcu N. Böbrek Transplantasyonu Olacak Hasta Ve Donörlerin Uygulama Öncesi Anksiyete Düzeylerinin Saptanması Ve Verilen Eğitimin Anksiyeteye Etkisinin Araştırılması. Hemşirelik Bülteni. 1999;43:293–301.

9. 9. Trbojević J,Nešic D, Stojimirović B, Nešić V. Quality of life of end-stage renal failure patients receiving continuous ambulatory peritoneal dialysis. The Scientific Journal FACTA Universitatis.1998;5:64–68.
10. 10. Garcia-Garcia G, Harden P, Chapman J. The global role of kidney transplantation. Indian J Nephrol. 2012;22:77–82.https://doi.org/10.4103/0971-4065.97101.
11. 11. Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, Tugwell P, Campbell SM, Abeles M, Clark P, Fam AG, Farber SJ, Fiechtner JJ, Franklin CM, Gatter RA, Hamaty D, Lessard J, Lichtbroun AS, Masi AT, Mccain GA, Reynolds WJ, Romano TJ, Russell IJ, Sheon RP.The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum. 1990;33:160–172.
12. 12. Burckhardt CS, Clark SR, Bennett RM.The fibromyalgia impact questionnaire: development and validation. J Rheumatol. 1991;18:728–733.
13. 13. Sarmer S, Ergin S, Yavuzer G. The validity and reliability of the Turkish version of the Fibromyalgia impact questionnaire. Rheumatol Int. 2000;20:9–12.
14. 14. Middleton GD, McFarlin JE, Lipsky PE. The prevalence and clinical impact of fibromyalgia in systemic luğus erythematosus. Arthritis Rheum. 1994;37:1181–1188.
15. 15. Hudson JI, Hudson MS, Pliner LF, Goldenberg DL, Pope HG Jr. Fibromyalgia and major affective disorder: a controlled phenomenology and family history study. Am J Psychiatry. 1985;142:441–446.
16. 16. Wallace DJ, Wallace JB. Making sense of fibromyalgia, 2nd ed. New York, NY: Oxford University Press; 2014.
17. 17. Katz RS, Kravitz HM. Fibromyalgia, depression, and alcoholism: a family history study. J Rheumatol.1996;23:149–154..
18. 18. Staud R. Pharmacological treatment of fibromyalgia syndrome. Drugs, 2010;70:1–14. https://doi.org/10.2165/11530950-000000000-00000.
19. 19. Buskila D, Neumann L, Alhoashle A, Abu-Shakra M. Fibromyalgia syndrome in men,» Semin Arthritis Rheum.2000;30:47–51.
20. 20. Mufson M, Regestein QR.The spectrum of fibromyalgia disorders.Arthritis Rheum. 1993;36:647–650.
21. 21. Bigatti SM, Hernandez AM, Cronan TA, Rand KL. Sleep disturbances in fibromyalgia syndrome: relationship to pain and depression. Arthritis Rheum. 2008;59:961–967. https://doi.org/10.1002/art.23828.
22. 22. Dailey DL, Keffala VJ, Sluka KA. Do cognitive and physical fatigue tasks enhance pain, cognitive fatigue, and physical fatigue in people with fibromyalgia?. Arthritis Care Res (Hoboken). 2015;67:288–296. https://doi.org/10.1002/acr.22417.
23. 23. Yunus MB, Masi AT. Juvenile primary fibromyalgia syndrome: a clinical study of thirty-three patients and matched normal controls. Arthritis Rheum. 1985;28:138–145.
24. 24. Terzi R, Terzi H, Kale A. Evaluating the relation of premenstrual syndrome and primary dysmenorrhea in women diagnosed with fibromyalgia. Rev Bras Reumatol. 2015;55:334–339. https://doi.org/10.1016/j.rbr.2014.12.009.
25. 25. Wolfe F, Petri M, Alarcón GS, Goldman J, Chakravarty EF, Katz RS, Karlson EW. Fibromyalgia, systemic lupus erythematosus and evaluation of SLE activity. J Rheumatol. 2009;36:82–88. https://doi.org/10.3899/jrheum.080212.
26. 26. Yunus MB, Aldag JC. Restless legs syndrome and leg cramps in fibromyalgia syndrome: a controlled study. BMJ. 1996;312:1339.
27. 27. Yılmaz S, Erdem H. Fibromiyalji sendromunun klinik ve laboratuar bulguları. Turkiye Klinikleri J Immunol Rheumatol-Special Topics. 2009;2:9–15.
28. 28. Fitzcharles MA, Shir Y, Ablin JN, Buskila D, Amital H, Henningsen P, Häuser W. Classification and clinical diagnosis of fibromyalgia syndrome: recommendations of recent evidence-based interdisciplinary guidelines. Evid Based Complement Alternat Med. 2013;2013:528952. https://doi.org/10.1155/2013/528952.