Clinical manifestations of Type 1 allergic reactions

Abstract

Abstract

Type I allergic reactions, also called atopic or anaphylactic type are IgE-mediated emergency hypersensitivity reactions. These are reactions triggered by re-exposure to a specific antigen called an allergen by ingestion, inhalation, injection or direct contact. IgE antibodies bind to mast cells and basophils containing histamine granules. Subsequent exposure to the same allergen leads to degranulation of the bound IgE and secretion of mediators such as histamine, leukotriene, prostaglandins. The reaction can be seen locally or systemically. Clinical manifestations of type I hypersensitivity reactions; urticaria, angioedema, anaphylaxis, atopic eczema, anaphylaxis, food and drug allergy, allergic asthma, allergic rhinitis and allergic conjunctivitis are grouped. The aim of this review is to review the clinical manifestations of all type 1 allergic reactions that are common and rare in daily dermatology practice, and to establish a connection between these mechanisms and the clinics.

Keywords

• Type 1,allergic

Tip 1 allerjik reaksiyonların klinik görünümleri

Abstract

Atopik veya anafilaktik tip olarak da adlandırılan Tip I allerjik reaksiyonları; Ig E aracılı acil hipersensitivite reaksiyonlarıdır. Alerjen olarak adlandırılan belirli bir antijene yutma, solunum, enjeksiyon veya doğrudan temas ile tekrar maruz kalınmasıyla tetiklenen reaksiyonlardır. IgE antikorları, histamin granülleri içeren mast hücrelerine ve bazofillere bağlanır. Aynı alerjene daha sonra maruz kalmak, bağlı IgE'nin degranülasyona yol açmasına ve histamin, lökotrien, prostaglandinler gibi mediatörlerin salgılanmasına neden olur. Reaksiyon lokal veya sistemik şekilde görülebilir. Tip I aşırı duyarlılık reaksiyonları sonucu oluşan klinik tablolar; ürtiker, anjiyoödem, anafilaksi,atopik egzema, anafilaksi, besin ve ilaç allerjileri, allerjik astım, allerjik rinit ve allerjik konjonktivit şeklinde gruplandırılır. Bu derlemenin amacı günlük dermatoloji pratiğinde sık ve nadir karşılaşığımız tüm tip 1 allerjik reaksiyonların klinik görünümlerini gözden geçirmek ve bu hastalıkların oluş mekanizmasıyla klinikleri arası bağlantı kurmak hedeflenmiştir.

Keywords

• Tip 1,allerjik

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