Comparison Of Pro-BNP Levels And Myocardial Performance Index Before And After Iron Treatment In Children With Congenital Cyanotic Heart Disease With Iron Deficiency Anemia

Year 2019, , 197 - 202, 30.09.2019

Adnan Barutçu , Sevcan Erdem , Fadli Demir , Saliha Barutçu , Göksel Leblebisatan

https://doi.org/10.16899/jcm.598034

Abstract

Introduction:
Our aim was to compare NT-proBNP levels and cardiac functions after iron
therapy in children with congenital cyanotic heart disease who had iron
deficiency anemia.

Materials
and Methods: We included 40 children with
pre-established cyanotic congenital heart disease and accompanying iron deficiency
anemia, between the age of 6 months and 17 years, who were admitted to the
outpatient clinic of Çukurova University Faculty of Medicine, Department of
Pediatric Cardiology between September 2015 and March 2016. We recorded
demographic data and performed following investigations: complete blood count,
peripheral blood smear, reticulocyte count, measurement of serum iron levels,
total iron-binding capacity, ferritin levels, transferrin saturation and
NT-proBNP levels, and echocardiographic examination.

Results:
There was a statistically significant increase in following laboratory
parameters after iron therapy: hemoglobin, hematocrit, MCV, MCHC, serum iron
and ferritin, transferrin saturation and oxygen saturation. During the
follow-up period, RDW and NT-proBNP levels were significantly decreased. In
left ventricular tissue doppler; there was a significant difference in MPI
measurements before and after treatment. There was no significant difference in
other echocardiography findings.

Conclusion:
Iron therapy has improved cardiac functions in children with cyanotic
congenital heart disease, and NT-proBNP levels can be used to evaluate the
efficacy of treatment in the follow-up period.

Keywords

Cyanotic congenital heart disease, iron deficiency anemia, NT-proBNP, echocardiography

Demir Eksikliği Anemisi Olan Doğumsal Siyanotik Kalp Hastalıklı Çocuklarda Demir Tedavisi Öncesi ve Sonrası Pro-BNP Düzeyleri ve Miyokardiyal Performans İndekslerinin Karşılaştırılması

Abstract

Amaç: Demir
eksikliği anemisi olan doğumsal siyanotik kalp hastalıklı çocuklarda demir
tedavisi sonrası NT-proBNP düzeyleri ve kardiyak fonksiyonların
karşılaştırılmasıdır.

Gereç
ve Yöntem:
Eylül 2015 - Mart 2016 tarihleri arasında
Çukurova Üniversitesi Tıp Fakültesi Çocuk Kardiyoloji Bilim Dalı polikliniğine
başvuran, siyanotik doğuştan kalp hastalığı tanılı, demir eksikliği anemisi
saptanan altı ay ile 17 yaşları arasındaki 40 çocuk hasta çalışmaya alınmıştır.
Çeşitli sebeplerden dolayı 26 hasta ile sonuçlar değerlendirilmiştir.
Hastaların ilk geliş ve üçüncü ay kontrollerinde; demografik verileri, tam kan
sayımı, periferik yayma, retikülosit, serum demir, total demir bağlama
kapasitesi, ferritin düzeyleri, transferrin satürasyonlarıu, NT-proBNP
düzeyleri ve Eko bulguları değerlendirilmiştir.

Bulgular: Hastaların
demir tedavisi öncesi ve sonrası laboratuvar değerlerinde; hemoglobin,
hematokrit, MCV, MCHC, demir, ferritin, transferin saturasyonu, oksijen saturasyonu
değerleri tedavi sonrası istatistiksel olarak anlamlı derece artmıştır. RDW ve
NT-proBNP düzeyleri yüksekliği kontrol sonuçlarında anlamlı olarak düşmüştür.
Sol ventrikül doku dopplerinde; MPİ ölçümlerinde tedavi öncesi ve sonrasında
anlamlı farklılık saptanmıştır. Diğer EKO bulgularında anlamlı farklılık
saptanmamıştır.

Sonuç: Demir
tedavisi sonrası siyanotik doğuştan kalp hastalıklı çocuklarda kardiyak
fonksiyonlarda iyileşme saptanmış olup NT-proBNP takipte, tedavinin
değerlendirilmesinde kullanılabilir.

Keywords

Siyanotik doğuştan kalp hastalığı, demir eksikliği anemisi, NT-proBNP, ekokardiyografi

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