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Is higher mean platelet volume an additional predictive marker of oligohydramnios and polyhydramnios?

Year 2019, , 209 - 213, 30.09.2019
https://doi.org/10.16899/jcm.605491

Abstract

Objectives:
Amniotic fluid abnormalities are the
leading cause of fetal morbidity and mortality.
The aim of this study
was to investigate whether prepartum mean platelet volume (MPV) is associated
with and a predictable marker for
oligohydramnios
(
OHA)
and
polyhydramnios (PHA).

Materials and Methods: In
this retrospective study, an examination was made of the records of patients
who were monitored and gave birth at Karabuk Training and Research Hospital
Gynecology and Obstetrics Clinic in 2014-2015. Patients with isolated OHA and
PHA were included in the study group and those with normal amnion fluid volume
(AFV) in the control group.  A record was
made of age, obstetric and clinical history, smoking, alcohol consumption,
laboratory test results and ultrasonography reports in the third trimester of
the pregnancy.

Results: A
total of 284 pregnant women were included in the study. The MPV levels of the
OHA and PHA groups were significantly higher than those of the normal group
(p=0.000). There was no significant difference was observed between the OHA and
PHA groups (p=0.20). MPV>8.4 accurately differentiated AFV
(AUC:68.8%, sensitivity:78.6%,
specificity:59.1%).
MPV>8.0 accurately differentiated OHA (AUC:67.1%,
sensitivity:84.4%, specificity:50.0%).
MPV>8.5 accurately
differentiated PHA
(AUC:70.2%,
sensitivity:79.0%, specificity:61.4%).







Conclusion: The result of the current study shows that
screening MPV has a predictive value for OHA and PHA in pregnancies without
complications or fetal anomaly.

References

  • Gizzo S, Noventa M, Vitagliano A, Dall'Asta A, D'Antona D, Aldrich CJ, et al. An Update on Maternal Hydration Strategies for Amniotic Fluid Improvement in Isolated Oligohydramnios and Normohydramnios: Evidence from a Systematic Review of Literature and Meta-Analysis. PloS one. 2015, 11: 10-12.
  • Benzer N, Tazegül Pekin A, Yılmaz SA, Kerimoğlu ÖS, Doğan NU, Çelik Ç. Predictive value of second and third trimester fetal renal artery Doppler indices in idiopathic oligohydramnios and polyhydramnios in low-risk pregnancies: A longitudinal study. Journal of Obstetrics and Gynaecology Research. 2015, 41: 523-528.
  • Aviram A, Salzer L, Hiersch L, Ashwal E, Golan G, Pardo J, et al. Association of isolated polyhydramnios at or beyond 34 weeks of gestation and pregnancy outcome. Obstetrics & Gynecology. 2015, 125: 825-832.
  • Hamza A, Herr D, Solomayer EF, Meyberg-Solomayer G. Polyhydramnios: Causes, Diagnosis and Therapy. Geburtshilfe Frauenheilkd. 2013, 73 (12): D1241-D1246. Balbaloglu O, Korkmaz M, Yolcu S, Karaaslan F, Beceren NG. Evalution of mean platelet volume (MPV) levels in patient with synovitis associated with knee osteoarthritis. Platelets. 2014, 25: 81-85.
  • Juan P, Stefano G, Antonella S, Albana C. Platelets in pregnancy. Journal of Prenatal Medicine. 2011, 5: 90.
  • Buyukkaya R, Buyukkaya A, Erkan M, Ozturk B, Yazgan S. Relationship between placental grade and mean platelet volum. Platelets. 2014, 25: 229-233.
  • Han L, Liu X, Li H, Zou J, Yang Z, Han J, et al. Blood coagulation parameters and platelet indices: changes in normal and preeclamptic pregnancies and predictive values for preeclampsia. PLoS One. 2014, 2: 1-14.
  • Arduini D, Rizzo G. Fetal renal artery velocity waveforms and amniotic fluid volume in growth retarded and post-term fetuses. Obstet Gynecol. 1991, 77: 370–373.
  • Leibovitch L, Kuint J, Rosenfeld E, Schushan-Eisen I, Weissmann-Brenner A, Maayan-Metzger A. Short-term outcome among term singleton infants with intrapartum oligohydramnios. Acta Pædiatrica. 2012, 101: 727–730.
  • Özdemirci Ş, Başer E, Kasapoğlu T, Karahanoğlu E, Kahyaoglu I, Yalvaç S, et al. Predictivity of mean platelet volume in severe preeclamptic women. Hypertens Pregnancy. 2016, 17: 1-9.
  • Moraes D, Munhoz TP, Pinheiro da Costa BE, Hentschke MR, Sontag F, Silveira Lucas L, et al. Immature platelet fraction in hypertensive pregnancy. Platelets. 2016, 27 (4): 333-337.
  • Iyidir OT, Degertekin CK, Yilmaz BA, Toruner FB, Akturk M, Arslan M. Elevated mean platelet volume is associated with gestational diabetes mellitus. Gynecol Endocrinol. 2014, 30 (9): 640-643.
  • Sak ME, Soydinç HE, Ozler A, Evsen MS, Turgut A, Sak S, et al. Platelet profile in patients with gestational diabetes: a retrospective study. J Turk Ger Gynecol Assoc. 2012, 13 (4): 223-226.
  • Erikci AA, Muhcu M, Dundar O, Oztürk A. Could mean platelet volume be a predictive marker for gestational diabetes mellitus? Hematology. 2008, 13: 46-48.
  • Gioia S, Cerekja A, Larciprete G, Vallone C, Demaliaj E, Evangelista MT, et al. Gestational diabetes: is it linked to platelets hyperactivity? Platelets. 2009, 20: 140-141.
  • Umazume T, Yamada T, Morikawa M, Ishikawa S, Furuta I, Koyama T, et al. Platelet reactivity in twin pregnancies. Thromb Res. 2016, 138: 43-48.
  • Karaman E, Çim N, Alkış İ, Yıldızhan R, Elçi G. Evaluation of mean platelet volume in unruptured ectopic pregnancy: A retrospective analysis. J Obstet Gynaecol. 2016, 36 (5): 622-625.
  • Gagnon R, Harding R, Brace RA. Amniotic fluid volume and fetal urinary response to severe placental insufficiency in sheep. Am J Obstet and Gynecol. 2002;186:1076.
  • Baschat AA, Gembruch U, Reiss I, Gortner L, Weiner CP, Harman CR. Absent umbilical artery end‐diastolic velocity in growth‐restricted fetuses: a risk factor for neonatal thrombocytopenia.Obstet Gynecol 2000; 96: 162–166.
  • Battaglia C, Artini PG, Ballestri M, Bonucchi D, Galli PA, Bencini S, et al. Hemodynamic, hematological and hemorrheological evaluation of post-term pregnancy. Acta obstetricia et gynecologica Scandinavica. 1995, 74: 336-340.
  • Tüzün A, Keskin O, Yakut M, Kalkan C, Soykan I, et al. The predictive value of mean platelet volume, plateletcrit and red cell distribution width in the differentiation of autoimmune gastritis patients with and without type I gastric carcinoid tumors. Platelets. 2014, 25: 363-366.

Yüksek ortalama trombosit hacmi oligohidramnios ve polihidramnios için ek bir prediktif belirteç midir?

Year 2019, , 209 - 213, 30.09.2019
https://doi.org/10.16899/jcm.605491

Abstract

Amaç:
Amniyotik sıvı anomalileri, fetal
morbidite ve mortalitenin önde gelen nedenleridir. Bu çalışmanın amacı,
prepartum ortalama trombosit hacminin (MPV), oligohidramnios (OHA) ve
polihidramnios (PHA) ile ilişkisini inceleyerek prediktif bir marker olup
olmadığını araştırmaktır.

Gereç
ve Yöntem:
Bu
retrospektif çalışmada, 2014-2015 yılları arasında Karabük Eğitim ve Araştırma
Hastanesi Kadın Hastalıkları ve Doğum Kliniği'nde izlenen ve doğum yapan
hastaların kayıtları incelenmiştir. İzole OHA ve PHA'lı hastalar çalışma
grubuna, normal amniyon sıvısı hacmine (AFV) sahip hastalar ise kontrol grubuna
dahil edildi. Gebeliğin üçüncü trimesterinde yaş, obstetrik ve klinik öykü,
sigara kullanımı, alkol tüketimi, laboratuvar test sonuçları ve ultrasonografi
rapor sonuçları kaydedildi.

Bulgular: Çalışmaya
toplam 284 gebe dahil edildi. OHA ve PHA gruplarının MPV seviyeleri kontrol
grubuna göre anlamlı derecede yüksekti (p<0.05). OHA ve PHA grupları
arasındaistatistiksel olarak anlamlı fark görülmedi (p>0.05). MPV> 8.4,
AFV'yi doğru bir şekilde farklılaştırdı (AUC:% 68.8, duyarlılık:% 78.6,
özgüllük:% 59.1). MPV> 8.0, OHA'yı doğru şekilde farklılaştırdı (AUC:% 67.1,
duyarlılık:% 84.4, özgüllük:% 50.0). MPV> 8.5, PHA'yı doğru bir şekilde
farklılaştırdı (AUC:% 70.2, duyarlılık:% 79.0, özgüllük:% 61.4).







Tartışma: Bu
çalışmanın sonuçları; MPV taramasının komplikasyon veya fetal anomali olmayan
gebeliklerde OHA ve PHA için prediktif bir değere sahip olduğunu
göstermektedir.

References

  • Gizzo S, Noventa M, Vitagliano A, Dall'Asta A, D'Antona D, Aldrich CJ, et al. An Update on Maternal Hydration Strategies for Amniotic Fluid Improvement in Isolated Oligohydramnios and Normohydramnios: Evidence from a Systematic Review of Literature and Meta-Analysis. PloS one. 2015, 11: 10-12.
  • Benzer N, Tazegül Pekin A, Yılmaz SA, Kerimoğlu ÖS, Doğan NU, Çelik Ç. Predictive value of second and third trimester fetal renal artery Doppler indices in idiopathic oligohydramnios and polyhydramnios in low-risk pregnancies: A longitudinal study. Journal of Obstetrics and Gynaecology Research. 2015, 41: 523-528.
  • Aviram A, Salzer L, Hiersch L, Ashwal E, Golan G, Pardo J, et al. Association of isolated polyhydramnios at or beyond 34 weeks of gestation and pregnancy outcome. Obstetrics & Gynecology. 2015, 125: 825-832.
  • Hamza A, Herr D, Solomayer EF, Meyberg-Solomayer G. Polyhydramnios: Causes, Diagnosis and Therapy. Geburtshilfe Frauenheilkd. 2013, 73 (12): D1241-D1246. Balbaloglu O, Korkmaz M, Yolcu S, Karaaslan F, Beceren NG. Evalution of mean platelet volume (MPV) levels in patient with synovitis associated with knee osteoarthritis. Platelets. 2014, 25: 81-85.
  • Juan P, Stefano G, Antonella S, Albana C. Platelets in pregnancy. Journal of Prenatal Medicine. 2011, 5: 90.
  • Buyukkaya R, Buyukkaya A, Erkan M, Ozturk B, Yazgan S. Relationship between placental grade and mean platelet volum. Platelets. 2014, 25: 229-233.
  • Han L, Liu X, Li H, Zou J, Yang Z, Han J, et al. Blood coagulation parameters and platelet indices: changes in normal and preeclamptic pregnancies and predictive values for preeclampsia. PLoS One. 2014, 2: 1-14.
  • Arduini D, Rizzo G. Fetal renal artery velocity waveforms and amniotic fluid volume in growth retarded and post-term fetuses. Obstet Gynecol. 1991, 77: 370–373.
  • Leibovitch L, Kuint J, Rosenfeld E, Schushan-Eisen I, Weissmann-Brenner A, Maayan-Metzger A. Short-term outcome among term singleton infants with intrapartum oligohydramnios. Acta Pædiatrica. 2012, 101: 727–730.
  • Özdemirci Ş, Başer E, Kasapoğlu T, Karahanoğlu E, Kahyaoglu I, Yalvaç S, et al. Predictivity of mean platelet volume in severe preeclamptic women. Hypertens Pregnancy. 2016, 17: 1-9.
  • Moraes D, Munhoz TP, Pinheiro da Costa BE, Hentschke MR, Sontag F, Silveira Lucas L, et al. Immature platelet fraction in hypertensive pregnancy. Platelets. 2016, 27 (4): 333-337.
  • Iyidir OT, Degertekin CK, Yilmaz BA, Toruner FB, Akturk M, Arslan M. Elevated mean platelet volume is associated with gestational diabetes mellitus. Gynecol Endocrinol. 2014, 30 (9): 640-643.
  • Sak ME, Soydinç HE, Ozler A, Evsen MS, Turgut A, Sak S, et al. Platelet profile in patients with gestational diabetes: a retrospective study. J Turk Ger Gynecol Assoc. 2012, 13 (4): 223-226.
  • Erikci AA, Muhcu M, Dundar O, Oztürk A. Could mean platelet volume be a predictive marker for gestational diabetes mellitus? Hematology. 2008, 13: 46-48.
  • Gioia S, Cerekja A, Larciprete G, Vallone C, Demaliaj E, Evangelista MT, et al. Gestational diabetes: is it linked to platelets hyperactivity? Platelets. 2009, 20: 140-141.
  • Umazume T, Yamada T, Morikawa M, Ishikawa S, Furuta I, Koyama T, et al. Platelet reactivity in twin pregnancies. Thromb Res. 2016, 138: 43-48.
  • Karaman E, Çim N, Alkış İ, Yıldızhan R, Elçi G. Evaluation of mean platelet volume in unruptured ectopic pregnancy: A retrospective analysis. J Obstet Gynaecol. 2016, 36 (5): 622-625.
  • Gagnon R, Harding R, Brace RA. Amniotic fluid volume and fetal urinary response to severe placental insufficiency in sheep. Am J Obstet and Gynecol. 2002;186:1076.
  • Baschat AA, Gembruch U, Reiss I, Gortner L, Weiner CP, Harman CR. Absent umbilical artery end‐diastolic velocity in growth‐restricted fetuses: a risk factor for neonatal thrombocytopenia.Obstet Gynecol 2000; 96: 162–166.
  • Battaglia C, Artini PG, Ballestri M, Bonucchi D, Galli PA, Bencini S, et al. Hemodynamic, hematological and hemorrheological evaluation of post-term pregnancy. Acta obstetricia et gynecologica Scandinavica. 1995, 74: 336-340.
  • Tüzün A, Keskin O, Yakut M, Kalkan C, Soykan I, et al. The predictive value of mean platelet volume, plateletcrit and red cell distribution width in the differentiation of autoimmune gastritis patients with and without type I gastric carcinoid tumors. Platelets. 2014, 25: 363-366.
There are 21 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Research
Authors

Neriman Çetin Benli 0000-0002-7487-0047

Sibel Mutlu 0000-0002-3149-5013

Abdülkerim Yıldız 0000-0002-9596-4042

Ali Ramazan Benli 0000-0003-0039-1497

Publication Date September 30, 2019
Acceptance Date August 15, 2019
Published in Issue Year 2019

Cite

AMA Çetin Benli N, Mutlu S, Yıldız A, Benli AR. Is higher mean platelet volume an additional predictive marker of oligohydramnios and polyhydramnios?. J Contemp Med. September 2019;9(3):209-213. doi:10.16899/jcm.605491